Gene Page:ARHGAP5

Summary?
GeneID 394
Symbol ARHGAP5
Synonyms GFI2|RhoGAP5|p190-B|p190BRhoGAP
Description Rho GTPase activating protein 5
Reference MIM:602680|HGNC:HGNC:675|Ensembl:ENSG00000100852|HPRD:04060|
Gene type protein-coding
Map location 14q12
Pascal p-value 0.035

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.047

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPR34 0.74 0.62
ADORA3 0.73 0.60
C1QC 0.73 0.65
RGS10 0.73 0.66
CD86 0.72 0.62
LAPTM5 0.71 0.62
CD53 0.71 0.64
AIF1 0.70 0.64
LY86 0.70 0.61
CTSS 0.70 0.64
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF814 -0.33 -0.37
ANKRD36 -0.30 -0.35
CRIPAK -0.30 -0.31
AC005921.3 -0.29 -0.31
AC004148.1 -0.29 -0.37
SLFNL1 -0.29 -0.27
CYP2D6 -0.29 -0.33
DUOX1 -0.29 -0.26
AC174470.2 -0.28 -0.27
AC092143.1 -0.28 -0.34

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005100 Rho GTPase activator activity TAS 8537347
GO:0003924 GTPase activity TAS 8537347
GO:0005096 GTPase activator activity IEA -
GO:0005525 GTP binding IEA -
GO:0042169 SH2 domain binding 新闻学会 1689011
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007155 cell adhesion TAS 8537347
GO:0007266 Rho protein signal transduction TAS 8537347
GO:0007165 signal transduction IEA -
GO:0007264 small GTPase mediated signal transduction IEA -
蜂窝组件 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005737 cytoplasm TAS 8537347
GO:0016020 membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY 13 8 All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY 24 17 All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 31 22 All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY 32 23 All SZGR 2.0 genes in this pathway
PID RHOA REG PATHWAY 46 30 All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 54 37 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP 79 50 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194 122 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
通过ELK3和HIF1严重缺氧A UP 142 104 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 58 43 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 80 56 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 11 57 40 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS 85 47 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196 137 All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245 148 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP 20 14 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP 41 26 All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP 193 95 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP 93 62 All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS DN 14 9 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 98 67 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-137 1041 1047 1A 保险公司-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-15/16/195/424/497 1210 1216 m8 保险公司-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
保险公司-miR-16brain UAGCAGCACGUAAAUAUUGGCG
保险公司-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
保险公司-miR-195SZ UAGCAGCACAGAAAUAUUGGC
保险公司-miR-424 CAGCAGCAAUUCAUGUUUUGAA
保险公司-miR-497 CAGCAGCACACUGUGGUUUGU
miR-153 2152 2158 m8 保险公司-miR-153 UUGCAUAGUCACAAAAGUGA
miR-186 705 711 1A 保险公司-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
保险公司-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 1148 1154 m8 保险公司-miR-19a UGUGCAAAUCUAUGCAAAACUGA
保险公司-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-194 2272 2279 1A,m8 保险公司-miR-194 UGUAACAGCAACUCCAUGUGGA
mir - 218 1650 1656 m8 保险公司-miR-218brain UUGUGCUUGAUCUAACCAUGU
mir - 223 1062 1068 1A 保险公司-miR-223 UGUCAGUUUGUCAAAUACCCC
miR-28 1426 1432 1A 保险公司-miR-28brain AAGGAGCUCACAGUCUAUUGAG
miR-299-5p 942 948 1A 保险公司-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-320 1751 1757 1A 保险公司-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-369-3p 1569 1575 1A 保险公司-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 1569 1576 1A,m8 保险公司-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-376c 1888 1894 1A 保险公司-miR-376c AACAUAGAGGAAAUUCCACG
miR-486 1892 1899 1A,m8 保险公司-miR-486 UCCUGUACUGAGCUGCCCCGAG
miR-493-5p 1890 1896 m8 保险公司-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-494 2529 2535 1A 保险公司-miR-494brain UGAAACAUACACGGGAAACCUCUU
保险公司-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-495 2293 2299 m8 保险公司-miR-495brain AAACAAACAUGGUGCACUUCUUU
保险公司-miR-495brain AAACAAACAUGGUGCACUUCUUU
保险公司-miR-495brain AAACAAACAUGGUGCACUUCUUU
保险公司-miR-495brain AAACAAACAUGGUGCACUUCUUU