Gene Page:LIFR
概括?
| 基因 | 3977 |
| Symbol | LIFR |
| Synonyms | CD118|LIF-R|SJS2|STWS|SWS |
| Description | leukemia inhibitory factor receptor alpha |
| Reference | MIM:151443|HGNC:HGNC:6597|Ensembl:ENSG00000113594|HPRD:01048|Vega:OTTHUMG00000131138 |
| Gene type | protein-coding |
| Map location | 5p13-p12 |
| Pascal p-value | 0.5 |
| Fetal beta | -0.48 |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | 与精神分裂症Co-occurance关键字s: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs695809 | chr22 | 26278127 | LIFR | 3977 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| 据 | HCNTF | ciliary neurotrophic factor | - | HPRD | 12643274 |
| CNTFR | MGC1774 | ciliary neurotrophic factor receptor | - | HPRD,BioGRID | 11285233|11943154 |12707266 |
| CTF1 | CT-1 | CT1 | cardiotrophin 1 | - | HPRD | 11834704 |
| IL31RA | CRL | CRL3 | GLM-R | GLMR | GPL | IL-31RA | MGC125346 | PRO21384 | interleukin 31 receptor A | - | HPRD | 14504285|15184896 |
| IL6ST | CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta | interleukin 6 signal transducer (gp130, oncostatin M receptor) | - | HPRD,BioGRID | 12047380 |
| LIF | CDF | DIA | HILDA | leukemia inhibitory factor (cholinergic differentiation factor) | - | HPRD,BioGRID | 12601009 |
| OSM | MGC20461 | oncostatin M | - | HPRD,BioGRID | 1536831|1542794 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD,BioGRID | 7512571 |
| POU2F1 | OCT1 | OTF1 | POU class 2 homeobox 1 | - | HPRD | 10383413 |
| PTPN11 | BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2 | protein tyrosine phosphatase, non-receptor type 11 | - | HPRD,BioGRID | 10800945 |
| PTPN6 | HCP |HCPH |HPTP1C |PTP-1C |SH-PTP1 |SHP-1 |SHP-1L |SHP1 | protein tyrosine phosphatase, non-receptor type 6 | - | HPRD,BioGRID | 10800945 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | 该途径中的所有SZGR 2.0基因 |
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | 该途径中的所有SZGR 2.0基因 |
| PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP | 205 | 140 | 该途径中的所有SZGR 2.0基因 |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | 该途径中的所有SZGR 2.0基因 |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | 该途径中的所有SZGR 2.0基因 |
| WIKMAN ASBESTOS LUNG CANCER UP | 17 | 11 | 该途径中的所有SZGR 2.0基因 |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | 该途径中的所有SZGR 2.0基因 |
| UDAYAKUMAR MED1 TARGETS DN | 240 | 171 | 该途径中的所有SZGR 2.0基因 |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | 该途径中的所有SZGR 2.0基因 |
| DELYS THYROID CANCER DN | 232 | 154 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | 该途径中的所有SZGR 2.0基因 |
| GAUSSMANN MLL AF4 FUSION TARGETS F UP | 185 | 119 | 该途径中的所有SZGR 2.0基因 |
| BEGUM TARGETS OF PAX3 FOXO1 FUSION UP | 60 | 45 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP53 TARGETS | 1174 | 695 | 该途径中的所有SZGR 2.0基因 |
| RASHI RESPONSE TO IONIZING RADIATION 4 | 61 | 34 | 该途径中的所有SZGR 2.0基因 |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 27 | 15 | 8 | 该途径中的所有SZGR 2.0基因 |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | 236 | 139 | 该途径中的所有SZGR 2.0基因 |
| 里克曼头颈癌 | 100 | 63 | 该途径中的所有SZGR 2.0基因 |
| NELSON RESPONSE TO ANDROGEN UP | 86 | 61 | 该途径中的所有SZGR 2.0基因 |
| GUO HEX TARGETS UP | 81 | 54 | 该途径中的所有SZGR 2.0基因 |
| HOFMANN CELL LYMPHOMA UP | 50 | 35 | 该途径中的所有SZGR 2.0基因 |
| YU MYC TARGETS DN | 55 | 38 | 该途径中的所有SZGR 2.0基因 |
| MUNSHI MULTIPLE MYELOMA UP | 81 | 52 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 48HR UP | 180 | 125 | 该途径中的所有SZGR 2.0基因 |
| TSENG IRS1 TARGETS DN | 135 | 88 | 该途径中的所有SZGR 2.0基因 |
| WANG SMARCE1 TARGETS UP | 280 | 183 | 该途径中的所有SZGR 2.0基因 |
| HAN JNK SINGALING DN | 39 | 27 | 该途径中的所有SZGR 2.0基因 |
| STEIN ESRRA TARGETS UP | 388 | 234 | 该途径中的所有SZGR 2.0基因 |
| Heller HDAC靶向被甲基化的沉默 | 461 | 298 | 该途径中的所有SZGR 2.0基因 |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | 该途径中的所有SZGR 2.0基因 |
| MATZUK IMPLANTATION AND UTERINE | 22 | 15 | 该途径中的所有SZGR 2.0基因 |
| BREDEMEYER RAG SIGNALING NOT VIA ATM DN | 57 | 34 | 该途径中的所有SZGR 2.0基因 |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | 该途径中的所有SZGR 2.0基因 |
| BOYLAN MULTIPLE MYELOMA D DN | 78 | 34 | 该途径中的所有SZGR 2.0基因 |
| ICHIBA GRAFT VERSUS HOST DISEASE D7 DN | 40 | 22 | 该途径中的所有SZGR 2.0基因 |
| Ichiba移植与宿主疾病35D DN | 49 | 34 | 该途径中的所有SZGR 2.0基因 |
| VANASSE BCL2 TARGETS UP | 40 | 25 | 该途径中的所有SZGR 2.0基因 |
| SWEET LUNG CANCER KRAS DN | 435 | 289 | 该途径中的所有SZGR 2.0基因 |
| STEIN ESRRA TARGETS | 535 | 325 | 该途径中的所有SZGR 2.0基因 |
| BOYLAN MULTIPLE MYELOMA PCA3 DN | 69 | 38 | 该途径中的所有SZGR 2.0基因 |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 | 76 | 54 | 该途径中的所有SZGR 2.0基因 |
| NAKAMURA ADIPOGENESIS EARLY UP | 66 | 44 | 该途径中的所有SZGR 2.0基因 |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | 该途径中的所有SZGR 2.0基因 |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | 该途径中的所有SZGR 2.0基因 |
| GABRIELY MIR21 TARGETS | 289 | 187 | 该途径中的所有SZGR 2.0基因 |
| JOHNSTONE PARVB TARGETS 1 DN | 63 | 39 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | 该途径中的所有SZGR 2.0基因 |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | 该途径中的所有SZGR 2.0基因 |
| PLASARI TGFB1 TARGETS 10HR DN | 244 | 157 | 该途径中的所有SZGR 2.0基因 |
| LIM MAMMARY STEM CELL UP | 489 | 314 | 该途径中的所有SZGR 2.0基因 |
| ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF | 51 | 29 | 该途径中的所有SZGR 2.0基因 |