Gene Page:ARL1

Summary?
GeneID 400
Symbol ARL1
Synonyms ARFL1
Description ADP ribosylation factor like GTPase 1
Reference MIM:603425|HGNC:HGNC:692|Ensembl:ENSG00000120805|HPRD: 04574|Vega:OTTHUMG00000170271
Gene type protein-coding
Map location 12q23.2
Pascal p-value 0.135
Sherlock p-value 0.582
Fetal beta -1.856
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Nucleus accumbens basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0032

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20866788 12 101802016 ARL1 2.88E-8 -0.009 8.9E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PSMA2 0.91 0.89
TBCA 0.91 0.89
RBM34 0.91 0.89
ERH 0.90 0.91
TMSB10 0.89 0.91
SARNP 0.89 0.88
GLRX3 0.89 0.91
DPY30 0.88 0.87
POLB 0.88 0.88
DPH5 0.88 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.2 -0.64 -0.74
AF347015.15 -0.63 -0.73
AF347015.26 -0.63 -0.73
AF347015.33 -0.63 -0.71
MT-CYB -0.63 -0.71
AF347015.8 -0.62 -0.70
AF347015.27 -0.62 -0.70
MT-CO2 -0.61 -0.67
TINAGL1 -0.60 -0.69
SLC6A12 -0.60 -0.69

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003924 GTPase activity TAS 9624189
GO:0005515 protein binding 新闻学会 17353931
GO:0005525 GTP binding IEA -
GO:0008047 enzyme activator activity TAS 9624189
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007264 small GTPase mediated signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IDA 11256614
GO:0005622 intracellular IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
NAM FXYD5 TARGETS DN 18 11 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 66 42 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
BARRIER COLON CANCER RECURRENCE UP 42 28 All SZGR 2.0 genes in this pathway
CHOW RASSF1 TARGETS DN 29 19 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
SHARMA PILOCYTIC ASTROCYTOMA LOCATION UP 25 12 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 115 73 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-496 203 209 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-9 405 411 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA