SZGR2 - Beplay体育中心

Summary？

基因	4001
象征	LMNB1
Synonyms	adld \| lmn \| lmn2 \| lmnb
Description	Lamin B1
Reference	MIM:150340\|HGNC:HGNC:6637\|Ensembl:ENSG00000113368\|HPRD：01036\|Vega:OTTHUMG00000128969
基因类型	蛋白质编码
Map location	5q23.2
Pascal p-value	0.165
胎儿β	3.841
DMG	2(# studies)
主持人	元
Support	G2CDB.HUMANNRC

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Nishioka_2013	全基因组DNA甲基化分析	作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。	2
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	2
GSMA_I	Genome scan meta-analysis	PSR：0.0032
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0147

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
cg10204478	5	126163548	LMNB1	1.057E-4	0.274	0.028	DMG：Wockner_2014
CG23953133	5	126112875	LMNB1		-0.02	0.43	DMG：Nishioka_2013

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
Utrn	0.75	0.76
AFF1	0.73	0.74
asxl2	0.73	0.71
atxn1l	0.70	0.70
WNK1	0.70	0.70
PTPN11	0.69	0.68
CREB3L2	0.69	0.68
NTRK2	0.69	0.69
KIAA1671	0.68	0.72
DDR2	0.68	0.71

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PFDN5	-0.40	-0.46
C8orf59	-0.39	-0.46
ST20	-0.39	-0.49
RPL31	-0.39	-0.48
RPL35	-0.38	-0.45
CCDC72	-0.37	-0.43
ATP5E	-0.37	-0.48
MRPL52	-0.37	-0.44
ROMO1	-0.37	-0.44
PHPT1	-0.37	-0.40

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0005198	structural molecule activity	IEA		-
GO:0005198	structural molecule activity	TAS		7557986
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005634	nucleus	IEA		-
去：0005637	核内膜	IEA		-
去：0005638	lamin filament	IEA		-
去：0005638	lamin filament	TAS		7557986
去：0016020	membrane	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
CASP3	CPP32 \|CPP32B \|SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	11901153
CASP6	MCH2	caspase 6，与凋亡相关的半胱氨酸肽酶	-	HPRD	11901153
CDC2	cdc28a \|CDK1 \|DKFZP686L20222 \|MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	11901153
EMD	EDMD \| LEMD5 \| STA	Emerin	亲和力捕获 - 韦斯特恩	Biogrid	12670476
lbr	DHCR14B \| FLJ43126 \| LMN2R \| MGC9041 \| PHA	椎板B受体	-	HPRD,BioGRID	12490158
LMNA	CDCD1 \| CDDC \| CMD1A \| CMT2B1 \| EMD2 \| FPL \| FPLD \| HGPS \| IDC \| LDP1 \| LFP \| LGMD1B \| LMN1 \| LMNC \| PRO1	lamin a/c	Lamin A interacts with Lamin B1.	绑定	7628545
LMNA	CDCD1 \| CDDC \| CMD1A \| CMT2B1 \| EMD2 \| FPL \| FPLD \| HGPS \| IDC \| LDP1 \| LFP \| LGMD1B \| LMN1 \| LMNC \| PRO1	lamin a/c	预胺A与lamin b1相互作用。	绑定	7628545
LMNA	CDCD1 \| CDDC \| CMD1A \| CMT2B1 \| EMD2 \| FPL \| FPLD \| HGPS \| IDC \| LDP1 \| LFP \| LGMD1B \| LMN1 \| LMNC \| PRO1	lamin a/c	-	HPRD,BioGRID	11792809
LMNA	CDCD1 \| CDDC \| CMD1A \| CMT2B1 \| EMD2 \| FPL \| FPLD \| HGPS \| IDC \| LDP1 \| LFP \| LGMD1B \| LMN1 \| LMNC \| PRO1	lamin a/c	Lamin C interacts with Lamin B1.	绑定	7628545
LMNB1	ADLD \| LMN \| LMN2 \| LMNB \| MGC111419	Lamin B1	Lamin B1与自身相互作用以形成同型二聚体。	绑定	7628545
prkca	AAG6 \|MGC129900 \|MGC129901 \|PKC-Alpha \|PKCA \|Prkaca	protein kinase C, alpha	-	HPRD,BioGRID	11901153\|12135703
Prkcb	MGC41878 \|pkc-beta \|PKCB \|prkcb1 \|PRKCB2	蛋白激酶C，β	-	HPRD,BioGRID	11901153
prkcd	May1 \|MGC49908 \|PKCD \|npkc-delta	蛋白激酶C，三角洲	-	HPRD	11901153
PRPH	nef4 \|PRPH1	peripherin	-	HPRD	1986862
TMPO	CMD1T \|lap2 \|LEMD4 \|MGC61508 \|Pro0868 \|TP	thymopoietin	-	HPRD,BioGRID	9490046
TOR1AIP1	DKFZP586G011 \|FLJ13142 \|lap1b \|MGC3413	torsin A interacting protein 1	-	HPRD	9305626
URB2	KIAA0133 \| MGC138837 \| MGC138838 \| NPA2	URB2核糖体生物发生2同源物（S. cerevisiae）	Lamin B1与LCO1相互作用。	绑定	15265697
URB2	KIAA0133 \| MGC138837 \| MGC138838 \| NPA2	URB2核糖体生物发生2同源物（S. cerevisiae）	-	HPRD	15265697

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
Biocarta FAS途径	30	22	All SZGR 2.0 genes in this pathway
Biocarta Hivnef途径	58	43	All SZGR 2.0 genes in this pathway
Biocarta TNFR1途径	29	21	All SZGR 2.0 genes in this pathway
PID caspase途径	52	39	All SZGR 2.0 genes in this pathway
反应组凋亡的细胞蛋白裂解	40	26	All SZGR 2.0 genes in this pathway
Reactome减数分裂	116	81	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
Reactome凋亡执行阶段	54	37	All SZGR 2.0 genes in this pathway
sotiriou乳腺癌1级vs 3	151	84	All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP	146	86	All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN	90	65	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
gal白血病干细胞DN	244	153	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
Bidus转移	214	134	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
受甲基化DN调节的Missiaglia	122	67	All SZGR 2.0 genes in this pathway
Tang衰老TP53靶向DN	57	33	All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE	123	80	All SZGR 2.0 genes in this pathway
Kong E2F3目标	97	58	All SZGR 2.0 genes in this pathway
罗斯蒂宫颈癌增殖簇	140	73	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT网络	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络	779	480	All SZGR 2.0 genes in this pathway
Pujana BRCA中心网络	117	72	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN	637	377	All SZGR 2.0 genes in this pathway
Ferreira Ewings肉瘤不稳定与稳定	167	92	All SZGR 2.0 genes in this pathway
FLI1和DAX1 DN的Garcia目标	176	104	All SZGR 2.0 genes in this pathway
Benporath循环基因	648	385	All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标	893	528	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP	86	49	All SZGR 2.0 genes in this pathway
Mori未成熟B淋巴细胞DN	90	55	All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE DN	75	43	All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN	309	206	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
郭十六进制靶向DN	65	36	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
Petrova内皮淋巴vs血液	131	87	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
KANG阿霉素耐药性	54	33	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
李小脑老化	84	58	All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上	428	266	All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应	318	220	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
外邦紫外线低剂量DN	67	46	All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN	46	38	All SZGR 2.0 genes in this pathway
外邦响应集群D3	61	39	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
Martinez TP53靶向	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
iwanaga癌变由Kras Pten Up	181	112	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
雄鹿癌俯卧反应E2	28	21	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
张乳腺癌祖细胞DN	145	93	All SZGR 2.0 genes in this pathway
Zheng胶质母细胞瘤可塑性	250	168	All SZGR 2.0 genes in this pathway
级结肠癌	871	505	All SZGR 2.0 genes in this pathway
植洛小儿所有疗法反应dn	29	17	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4 DN的响应	245	150	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
张TLX目标60小时DN	277	166	All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN	42	29	All SZGR 2.0 genes in this pathway
Croonquist IL6剥夺DN	98	69	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病	181	106	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP	178	108	All SZGR 2.0 genes in this pathway
Kobayashi EGFR信令24小时DN	251	151	All SZGR 2.0 genes in this pathway
PYEON CANCAR CANCAR HEAD和NECK与颈椎	193	95	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老	572	352	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS LOW SERUM	100	51	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时	324	193	All SZGR 2.0 genes in this pathway
Thillainadesan Znf217靶向	44	22	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP	221	120	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway
IR响应6小时中的周细胞周期基因	85	49	All SZGR 2.0 genes in this pathway
24小时IR响应中的周细胞周期基因	128	73	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-101	231	237	M8	hsa-miR-101	uacaguacugauaacugaag
mir-124.1	131	137	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
mir-218	74	80	M8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-23	198	204	1A	HSA-MIR-23A^brain	AUCACAUUGCCAGGGAUUUCC
				HSA-MIR-23B^brain	AUCACAUUGCCAGGGAUUACC
				HSA-MIR-23A^brain	AUCACAUUGCCAGGGAUUUCC
				HSA-MIR-23B^brain	AUCACAUUGCCAGGGAUUACC
mir-30-3p	151	157	M8	HSA-MIR-30A-3P	CUUUCAGUCGGAUGUUUGCAGC
mir-30-3p	151	157	M8	HSA-MIR-30E-3P	cuuucagucggauguauacagc

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:LMNB1