SZGR2 - Beplay体育中心

Summary？

GeneID	4023
象征	LPL
Synonyms	HDLCQ11 \| LIPD
Description	脂蛋白脂肪酶
Reference	MIM:609708\|HGNC:HGNC:6677\|ENSEMBL：ENSG00000175445\|HPRD:01999\|Vega:OTTHUMG00000036645
基因类型	蛋白质编码
Map location	8p22
pascal p-value	0.114
Sherlock p-value	0.54
胎儿β	2.196
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS
简历：Phewas	phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	1
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I	Genome scan meta-analysis	psr: 0.031
GSMA_IIA	Genome scan meta-analysis (All samples)	PSR：0.03086
gsma_iie	Genome scan meta-analysis (European-ancestry samples)	psr: 0.00057
表达	Meta-analysis of gene expression	pvalue: 1.479
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	支安打与neuro-related关键词:1

Section I. Genetics and epigenetics annotation

简历：Phewas

SNP ID	染色体	位置	Allele	p	功能	Gene	向上/向下距离
RS2083637	8	19865175	无效的	0.601	LPL	无效的

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	QVALUE	EQTL类型
rs33157	chr12	30987976	LPL	4023	0.08	反式
rs12853449	chr13	26127889	LPL	4023	0.19	反式
RS4551866	chr13	26147653	LPL	4023	0.19	反式
RS7277730	chr21	19517965	LPL	4023	0.12	反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	pearson's Correlation	Spearman's Correlation
DDX47	0.87	0.88
GNPAT	0.86	0.89
ZW10	0.86	0.84
DHX40	0.86	0.86
clns1a	0.85	0.81
NUP35	0.84	0.84
BPGM	0.84	0.85
VPS45	0.84	0.89
USP39	0.84	0.87
STT3A	0.84	0.84

Top 10 negatively co-expressed genes
Gene	pearson's Correlation	Spearman's Correlation
MT-CO2	-0.72	-0.77
AF347015.8	-0.71	-0.78
AF347015.33	-0.70	-0.77
AF347015.27	-0.70	-0.76
AF347015.15	-0.68	-0.77
AF347015.2	-0.68	-0.78
mt-cyb	-0.68	-0.75
AF347015.26	-0.68	-0.78
AF347015.31	-0.67	-0.74
AF347015.21	-0.65	-0.73

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005102	receptor binding	IPI	神经递质（GO期限：4）	10085125
GO:0004620	磷脂酶活性	ISS		10727238
去：0005319	脂质转运蛋白活性	IEA		-
GO:0004806	三酰基甘油脂肪酶活性	ISS		10727238
去：0004465	脂蛋白脂肪酶活性	IEA		-
GO：0016787	水解酶活性	IEA		-
GO:0008201	肝素约束	TAS		1969408
生物过程	去学期	证据	神经关键字	PubMed ID
GO：0016042	lipid catabolic process	IEA		-
GO:0008015	血液循环	TAS		1969408
去：0006644	phospholipid metabolic process	ISS		10727238
去：0006641	三酰基甘油代谢过程	ISS		10727238
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	TAS		1969408
去：0005886	plasma membrane	IEA		-
GO:0031225	锚定在膜上	IEA		-
GO：0042627	chylomicron	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
APOC2	MGC75082	载脂蛋白C-II	-	HPRD	10727238\|11579204
ASCC2	ASC1p100	activating signal cointegrator 1 complex subunit 2	Two-hybrid	Biogrid	16169070
CETP	HDLCQ10	胆固醇酯转移蛋白，血浆	-	HPRD	9374130
COPS6	CSN6 \|MOV34-34KD	COP9本构型显微类同源物亚基6（拟南芥）	Two-hybrid	Biogrid	16169070
EMD	EDMD \| LEMD5 \| STA	Emerin	Two-hybrid	Biogrid	12755701
KIAA1377	-	KIAA1377	Two-hybrid	Biogrid	16169070
LRP1	A2MR \|apoer \|APR \|CD91 \|FLJ16451 \|IGFBP3R \|LRP \|MGC88725 \|TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD	1281473 \| 7510694\|7989348
LRP1	A2MR \|apoer \|APR \|CD91 \|FLJ16451 \|IGFBP3R \|LRP \|MGC88725 \|TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	重构的复合物	Biogrid	1281473\|7510694 \|7989348
LRP2	DBS \|GP330	低密度脂蛋白相关蛋白2	-	HPRD,BioGRID	7686151
LUC7L2	CGI-59 \|CGI-74 \|FLJ10657 \|luc7b2	LUC7-like 2 (S. cerevisiae)	Two-hybrid	Biogrid	16169070
pTPN4	ptpmeg \|PTPMEG1	蛋白质酪氨酸磷酸酶，非受体4型（巨核细胞）	Two-hybrid	Biogrid	16169070
RPL18A	-	核糖体蛋白L18A	Two-hybrid	Biogrid	16169070
UBE2Z	FLJ13855 \| HOYS7 \| USE1	ubiquitin-conjugating enzyme E2Z	Two-hybrid	Biogrid	16169070
VLDLR	CHRMQ1 \| FLJ35024 \| VLDLRCH	非常低密度脂蛋白受体	-	HPRD,BioGRID	7592875

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG甘油代谢	49	26	All SZGR 2.0 genes in this pathway
kegg ppar信号通路	69	47	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
白色脂肪细胞分化的Reactome转录调节	72	53	All SZGR 2.0 genes in this pathway
Reactome脂质消化和运输	46	37	All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM	28	24	All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	16	15	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP	175	120	All SZGR 2.0 genes in this pathway
Bilban b cll lpl up	63	39	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标	204	140	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合红细胞的TONKS目标	157	104	All SZGR 2.0 genes in this pathway
sabates结直肠腺瘤	141	75	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化Kras DN	142	95	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合目标F DN	33	24	All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
McBryan Pubertal TGFB1靶向	169	127	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
温曼对缺氧的适应	29	24	All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN	41	33	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
Borlak肝癌EGF UP	57	41	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM1	229	137	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM2	153	102	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
Petretto心脏肥大	34	26	All SZGR 2.0 genes in this pathway
LE EGR2目标DN	108	84	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc Up	54	30	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc TGFA UP	61	40	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP	64	40	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
李肝癌电抗	60	42	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Dena Up	60	40	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP	62	35	All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH MUTATED VH GENES	18	14	All SZGR 2.0 genes in this pathway
郭十六进制靶向DN	65	36	All SZGR 2.0 genes in this pathway
HOXA9和MEIS1 DN的HESS目标	77	48	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP	114	84	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
URS脂肪细胞分化	74	51	All SZGR 2.0 genes in this pathway
伯顿成生成10	30	17	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE DN	42	24	All SZGR 2.0 genes in this pathway
罗德韦尔衰老肾脏无血DN	150	93	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN	84	50	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
罗德韦尔老化的肾脏DN	145	88	All SZGR 2.0 genes in this pathway
Kaab心脏中心与心室DN	261	183	All SZGR 2.0 genes in this pathway
Burton脂肪形成峰在0hr	63	48	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
Weng Por靶向肝脏	41	29	All SZGR 2.0 genes in this pathway
伯顿成生成6	189	112	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应	953	554	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
Stearman肿瘤场效应	36	22	All SZGR 2.0 genes in this pathway
Stearman肺癌早期与晚期DN	61	39	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
Martinez TP53靶向	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN	564	326	All SZGR 2.0 genes in this pathway
Smid乳腺癌正常	476	285	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
LIN NPAS4靶向	163	One hundred.	All SZGR 2.0 genes in this pathway
CADWELL ATG16L1靶向	93	56	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP	131	79	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED	536	296	All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN	74	47	All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA2 DN	80	51	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6	75	48	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP	84	51	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
Changolkar H2AFY目标	48	28	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
wakabayashi脂肪生成pparg rxra绑定36小时	152	88	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK	145	82	All SZGR 2.0 genes in this pathway
pLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
Guillaumond KLF10靶向	51	39	All SZGR 2.0 genes in this pathway
寄养KDM1A靶向	266	142	All SZGR 2.0 genes in this pathway
Roessler肝癌转移	107	72	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN	99	74	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-29	1796	1803	1A，M8	HSA-MIR-29A^SZ	UAGCACCAUCUGAAAUCGGUU
				HSA-MIR-29B^SZ	UAGCACCAUUUGAAAUCAGUGUU
				HSA-MIR-29C^SZ	UAGCACCAUUUGAAAUCGGU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:LPL