Gene Page:LRP4

概括?
基因 4038
象征 LRP4
Synonyms CLSS|CMS17|LRP-4|LRP10|MEGF7|SOST2
Description LDL receptor related protein 4
Reference MIM:604270|HGNC:HGNC:6696|Ensembl:ENSG00000134569|HPRD:18517|Vega:OTTHUMG00000166700
Gene type protein-coding
Map location 11P11.2
Pascal p-value 5.581E-5
TADA p-value 0.029
Fetal beta -1.334
DMG 1 (# studies)
Support COMPOSITESET
Ascano FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM：Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur High-throughput literature-search 系统的搜索in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
LRP4 chr11 46903348 C T NM_002334 p.907G>R 错过 精神分裂症 DNM：Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23062006 11 46940220 LRP4 5.085E-4 -0.209 0.047 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
去：0004872 receptor activity IEA -
GO:0005509 钙离子结合 IEA -
GO:0005509 钙离子结合 NAS -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0051124 synaptic growth at neuromuscular junction IEA 胆碱能，突触（GO期限：11） -
GO:0001822 kidney development IEA -
GO:0001942 hair follicle development IEA -
GO:0009954 proximal/distal pattern formation IEA -
GO:0009953 dorsal/ventral pattern formation IEA -
GO:0008150 biological_process nd -
GO:0008104 蛋白质定位 IEA -
GO:0006897 endocytosis IEA -
GO:0030178 Wnt受体信号通路的负调控 IEA -
GO:0042475 odontogenesis of dentine-containing tooth IEA -
GO:0042733 embryonic digit morphogenesis IEA -
GO：0048856 anatomical structure development IEA -
GO:0043113 receptor clustering IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component nd -
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 77 46 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS 12HR UP 162 116 该途径中的所有SZGR 2.0基因
DELYS THYROID CANCER UP 443 294 该途径中的所有SZGR 2.0基因
DN CHEBOTAEV GR目标 120 73 该途径中的所有SZGR 2.0基因
ROVERSI GLIOMA COPY NUMBER UP 100 75 该途径中的所有SZGR 2.0基因
LUI甲状腺癌簇1 51 33 该途径中的所有SZGR 2.0基因
DAIRKEE TERT TARGETS UP 380 213 该途径中的所有SZGR 2.0基因
KIM MYCN AMPLIFICATION TARGETS UP 92 64 该途径中的所有SZGR 2.0基因
RICKMAN METASTASIS UP 344 180 该途径中的所有SZGR 2.0基因
Schaeffer前列腺开发12小时 116 79 该途径中的所有SZGR 2.0基因
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
DELASERNA MYOD TARGETS UP 89 51 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR UP 180 125 该途径中的所有SZGR 2.0基因
LU AGING BRAIN UP 262 186 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 该途径中的所有SZGR 2.0基因
BILD E2F3 ONCOGENIC SIGNATURE 246 153 该途径中的所有SZGR 2.0基因
riggins他莫昔芬抗性 66 44 该途径中的所有SZGR 2.0基因
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246 152 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
LIM MAMMARY STEM CELL UP 489 314 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-125/351 1112 1119 1A,m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain ucccugagacccuuaaccugug
miR-130/301 1870 1876 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152 1927 1933 1A hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-181 1888 1894 1A HSA-MIR-181Abrain aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-196 169 175 m8 hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-199 2020 2026 1A hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429 2064 2070 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-485-5p 528 535 1A,m8 HSA-MIR-485-5p AGAGGCUGGCCGUGAUGAAUUC