Gene Page:ARNTL

Summary？
基因 406
象征 ARNTL
Synonyms bmal1 | bmal1c | jap3 | mop3 | pasd3 | tic | bhlhe55
Description 芳基烃受体nuclear translocator like
Reference MIM：602550|HGNC:HGNC:701|ENSEMBL：ENSG00000133794|HPRD:03973|Vega：Otthumg00000150623
基因类型 蛋白质编码
Map location 11p15
Pascal p-value 0.016
Sherlock p-value 0.475
胎儿β -1.755
主持人 元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历：Gwascat 全基因组艾莎ciation Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb 全基因组艾莎ciation Studies 精神分裂症的GWASDB记录
CV:PGCnp 全基因组艾莎ciation Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
STK25 0.88 0.83
PSMB2 0.85 0.82
DDX41 0.85 0.80
TCF25 0.85 0.78
RXRB 0.85 0.82
MARS 0.84 0.80
AGAP3 0.84 0.77
GDI1 0.84 0.81
CACNB3 0.84 0.79
波尔萨 0.83 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
MT-CO2 -0.76 -0.67
AF347015.26 -0.75 -0.69
mt-cyb -0.72 -0.66
AF347015.31 -0.72 -0.67
AF347015.33 -0.72 -0.65
AF347015.2 -0.72 -0.64
AF347015.8 -0.72 -0.66
鼻孔 -0.70 -0.67
AF347015.21 -0.69 -0.67
AF347015.18 -0.69 -0.68

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004871 信号传感器活性 IEA -
GO:0003700 transcription factor activity IEA -
GO：0017162 芳基烃受体结合 IPI 9079689
GO：0051879 HSP90蛋白结合 艾达 9079689
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006355 调节转录，DNA依赖性的调节 IEA -
GO:0007165 信号转导 IEA -
去：0007623 circadian rhythm TAS 9616112
GO：0045944 RNA聚合酶II启动子的转录阳性调节 IGI 9576906
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IEA -
去：0005667 转录因子复合物 IPI 9576906

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
啊 - 芳基烃受体 - HPRD,BioGRID 9079689
BHLHB2 dec1 |Sharp-2 |Stra13 |Stra14 |Bhlhe40 basic helix-loop-helix domain containing, class B, 2 - HPRD 12397359
钟 kat13d |KIAA0334 |bhlhe8 clock homolog (mouse) Two-hybrid Biogrid 11439184|14701734
钟 kat13d |KIAA0334 |bhlhe8 clock homolog (mouse) - HPRD 9989497
CRY1 PHLL1 cryptochrome 1 (photolyase-like) - HPRD,BioGRID 10531061
CSNK1E HCKIE | MGC10398 酪蛋白激酶1，Epsilon - HPRD,BioGRID 11875063
EP300 kat3b |P300 E1A binding protein p300 重构的复合物 Biogrid 14645221
EPAS1 ecyt4 |hif2a |HLF |mop2 |PASD2 endothelial PAS domain protein 1 - HPRD,BioGRID 9576906
hif1a HIF-1Alpha |HIF1 |hif1-alpha |mop1 |PASD8 低氧诱导因子1，α亚基（基本螺旋 - 环螺旋转录因子） - HPRD,BioGRID 9576906
HSP90AA1 FLJ31884 |HSP86 |HSP89A |HSP90A |HSP90N |HSPC1 |HSPCA |HSPCAL1 |HSPCAL4 |HSPN | Hsp89 | Hsp90 | LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 - HPRD,BioGRID 9079689
kat2b CAF | P | P/CAF | PCAF K（赖氨酸）乙酰转移酶2B 重构的复合物 Biogrid 14645221
NPAS2 FLJ23138 |MGC71151 |mop4 |pasd4 |Bhlhe9 神经元PAS结构蛋白2 体外
in vivo
Two-hybrid		 Biogrid 9576906|11439184
NPAS4 le-pas |nxf |PASD10 神经元PAS结构蛋白4 - HPRD,BioGRID 14701734
拉拉 NR1B1 | RAR retinoic acid receptor, alpha 重构的复合物 Biogrid 11439184
RXRA FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 类维生素X受体，α 重构的复合物 Biogrid 11439184


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG CIRCADIAN RHYTHM MAMMAL 13 13 All SZGR 2.0 genes in this pathway
PID CIRCADIAN PATHWAY 16 15 All SZGR 2.0 genes in this pathway
Reactome BMAL1时钟NPAS2激活昼夜节律表达 36 27 All SZGR 2.0 genes in this pathway
Reactome Ppara激活基因表达 104 72 All SZGR 2.0 genes in this pathway
Reactome Rora激活昼夜节律表达 24 17 All SZGR 2.0 genes in this pathway
Reactome昼夜节律抑制Rev Erba的表达 23 16 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
反应组脂肪酸三酰甘油和酮体代谢 168 115 All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 53 40 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
Deurig t细胞促进性白血病DN 320 184 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
riz红细胞分化 77 51 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 84 54 All SZGR 2.0 genes in this pathway
Amundson对砷的回应 217 143 All SZGR 2.0 genes in this pathway
Wiemann端粒缩短和慢性肝脏损害 8 5 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM1 229 137 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
Shipp DLBCL治愈与致命DN 45 30 All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 88 62 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞QTL顺式 128 77 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK 169 111 All SZGR 2.0 genes in this pathway
DORSAM HOXA9靶向DN 32 22 All SZGR 2.0 genes in this pathway
MLL AF9融合的Kumar目标 405 264 All SZGR 2.0 genes in this pathway
Browne HCMV感染6小时 71 48 All SZGR 2.0 genes in this pathway
Bild MYC致癌签名 206 117 All SZGR 2.0 genes in this pathway
道格拉斯BMI1靶向DN 314 188 All SZGR 2.0 genes in this pathway
TUOMISTO TUMOR SUPPRESSION BY COL13A1 UP 18 9 All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性 578 341 All SZGR 2.0 genes in this pathway
MATZUK类固醇发生 7 6 All SZGR 2.0 genes in this pathway
Chen Hoxa5靶向9小时 223 132 All SZGR 2.0 genes in this pathway
CUI葡萄糖剥夺 60 44 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到 1137 655 All SZGR 2.0 genes in this pathway
DN KATSANOU ELAVL1目标 148 88 All SZGR 2.0 genes in this pathway
Servitja肝HNF1A靶向DN 157 105 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时 199 143 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
林乳腺干细胞向上 489 314 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-141/200a 193 199 M8 HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-142-3p 352 359 1A，M8 HSA-MIR-142-3P UGUAGUGUUUCCUACUUUAUGGA
miR-153 317 323 1a HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
miR-155 238 244 1a HSA-MIR-155 uuaaugcuaaucgugauagggg
mir-203.1 329 335 1a hsa-miR-203 ugaaauguuuaggaccacuag
miR-27 65 71 1a HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain uucacaguggcuaaguucugc
miR-381 245 251 1a HSA-MIR-381 uauacaagggcaagcucucugu
mir-448 316 323 1A，M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-494 490 496 M8 HSA-MIR-494brain ugaaacauacgggaaaccucuu
mir-505 267 274 1A，M8 hsa-miR-505 gucaacuugcugguuccuc