Gene Page:LY6H

Summary?
GeneID 4062
Symbol LY6H
Synonyms NMLY6
Description lymphocyte antigen 6 complex, locus H
Reference MIM:603625|HGNC:HGNC:6728|Ensembl:ENSG00000176956|HPRD: 04691|Vega:OTTHUMG00000154890
Gene type protein-coding
Map location 8q24.3
Pascal p-value 0.002
Sherlock p-value 0.937
Fetal beta -0.376
eGene Cerebellar Hemisphere
小脑
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RUFY3 0.92 0.94
VEZT 0.92 0.93
OGFOD1 0.92 0.92
STRN3 0.92 0.92
GSPT1 0.91 0.94
THUMPD3 0.91 0.92
DHX36 0.91 0.92
ZFP90 0.91 0.93
DIS3 0.91 0.92
KPNA3 0.91 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.81 -0.84
AF347015.8 -0.78 -0.84
AF347015.31 -0.78 -0.83
AF347015.27 -0.77 -0.81
AF347015.33 -0.77 -0.81
FXYD1 -0.77 -0.83
MT-CYB -0.76 -0.81
AF347015.21 -0.76 -0.82
IFI27 -0.76 -0.82
AF347015.15 -0.74 -0.81

Section III. Gene Ontology annotation

Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development TAS neurite (GO term level: 5) 9799603
GO:0009887 organ morphogenesis TAS 9799603
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane IEA -
GO:0031225 anchored to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 157 87 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163 111 All SZGR 2.0 genes in this pathway