Gene Page:SMAD6

Summary?
GeneID 4091
Symbol SMAD6
Synonyms AOVD2|HsT17432|MADH6|MADH7
Description SMAD family member 6
Reference MIM:602931|HGNC:HGNC:6772|HPRD:04240|
Gene type protein-coding
Map location 15q22.31
Pascal p-value 0.274
Fetal beta 0.09
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06103624 15 66998926 SMAD6 2.38E-5 0.533 0.017 DMG:Wockner_2014
cg04093349 15 66998947 SMAD6 3.978E-4 0.455 0.044 DMG:Wockner_2014
cg12175172 15 67073649 SMAD6 4.704E-4 0.324 0.046 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs8016302 chr14 95828478 SMAD6 4091 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SHFM1 0.81 0.77
CKS1B 0.80 0.64
NUDT5 0.79 0.72
SRP14 0.78 0.79
PIN4 0.78 0.78
AC106037.2 0.78 0.78
THOC4 0.77 0.70
SNRPF 0.77 0.76
LSM6 0.77 0.72
SYF2 0.77 0.70
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CYB -0.53 -0.58
AF347015.31 -0.52 -0.56
AF347015.2 -0.52 -0.58
MT-CO2 -0.51 -0.54
AF347015.33 -0.51 -0.56
AF347015.15 -0.51 -0.58
AF347015.9 -0.50 -0.59
AF347015.27 -0.50 -0.57
AF347015.26 -0.49 -0.58
AF347015.8 -0.49 -0.54

第四部分,注释蛋白质间交互作用

Interactors Aliases B Official full name B Experimental Source PubMed ID
CTBP1 BARS | MGC104684 C-terminal binding protein 1 Affinity Capture-Western BioGRID 14645520
HOXC8 HOX3 | HOX3A homeobox C8 - HPRD,BioGRID 10722652
MAP3K7 TAK1 | TGF1a mitogen-activated protein kinase kinase kinase 7 - HPRD,BioGRID 10748100
MAP3K7IP1 3'-Tab1 | MGC57664 | TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 - HPRD,BioGRID 11737269
PIAS4 FLJ12419 | MGC35296 | PIASY | Piasg | ZMIZ6 protein inhibitor of activated STAT, 4 Affinity Capture-Western
Two-hybrid		 BioGRID 12815042
RNF111 ARK | DKFZp313E0731 | DKFZp686H1966 | DKFZp761D081 | FLJ38008 ring finger protein 111 - HPRD,BioGRID 14657019
SMAD1 BSP1 | JV4-1 | JV41 | MADH1 | MADR1 SMAD家庭成员1 - HPRD 11483516
SMAD7 CRCS3 | FLJ16482 | MADH7 | MADH8 SMAD family member 7 - HPRD,BioGRID 9256479
SMURF1 KIAA1625 SMAD specific E3 ubiquitin protein ligase 1 - HPRD,BioGRID 11278251
STAMBP AMSH | MGC126516 | MGC126518 STAM binding protein - HPRD,BioGRID 11483516
STRAP MAWD | PT-WD | UNRIP serine/threonine kinase receptor associated protein - HPRD,BioGRID 10757800


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 37 29 All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 42 31 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 23 15 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232 139 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN 172 112 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS DN 24 13 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 77 51 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 40 26 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205 145 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 114 71 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11 63 45 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN 46 26 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 86 62 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS 44 29 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 36 24 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 101 64 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
GAUTSCHI SRC SIGNALING 8 6 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 36 21 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS 62 35 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION DN 12 10 All SZGR 2.0 genes in this pathway