Gene Page:MAL

概括?
基因 4118
Symbol MAL
Synonyms -
Description mal T-cell differentiation protein
Reference MIM:188860|HGNC:HGNC:6817|Ensembl:ENSG00000172005|HPRD:01789|Vega:OTTHUMG00000132011
Gene type protein-coding
Map location 2q11.1
Pascal p-value 0.479
Fetal beta -2.134
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0004
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6829546 chr4 12587664 MAL 4118 0.12 trans
rs6448932 chr4 12595798 MAL 4118 0.1 trans
rs7830259 chr8 14087643 MAL 4118 0.01 trans
rs4787041 chr16 7581317 MAL 4118 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008289 lipid binding TAS 10739088
GO:0016505 apoptotic protease activator activity NAS 10366425
GO:0015267 channel activity TAS 3494249
GO:0019911 structural constituent of myelin sheath IDA 12153479
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development TAS Brain (GO term level: 6) 10739088
GO:0042552 髓鞘 NAS neuron, axon, Brain, oligodendrocyte (GO term level: 13) 12153479
GO:0042552 髓鞘 TAS neuron, axon, Brain, oligodendrocyte (GO term level: 13) 10428054
GO:0001766 膜筏polarization TAS 12153479
GO:0006917 induction of apoptosis NAS 10366425
GO:0030154 cell differentiation TAS 10739088
GO:0045176 顶端的蛋白质定位 TAS 10739088
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005768 endosome TAS 9003426
GO:0005783 endoplasmic reticulum IDA 8132541
去：0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 9003426
GO:0016324 apical plasma membrane TAS 10739088
GO：0045121 膜筏 IDA 12153479

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384 220 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER DN 37 22 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 101 66 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS 36 25 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153 102 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 89 44 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 108 84 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 94 56 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH MUTATED VH GENES 18 14 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SPIKED 22 13 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN 46 26 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS 78 52 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP 45 29 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 97 53 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS NEURAL UP 18 13 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 51 29 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 146 90 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 151 86 All SZGR 2.0 genes in this pathway
BOSCO EPITHELIAL DIFFERENTIATION MODULE 69 31 All SZGR 2.0 genes in this pathway