Gene Page:MAP1B

概括？
基因 4131
象征 MAP1B
Synonyms FUTSCH | MAP5 | PPP1R102
Description microtubule associated protein 1B
Reference MIM:157129|HGNC:HGNC:6836|Ensembl：ENSG00000131711|HPRD：01139|Vega：Otthumg00000100952
基因类型 蛋白质编码
Map location 5Q13
Pascal p-value 0.558
Sherlock p-value 0.504
胎儿beta 0.952
耶和华 Cerebellar Hemisphere
小脑
皮质
Frontal Cortex BA9
Myers' cis & trans
Support 结构可塑性
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS
G2CDB.HUMAN_CLATHRIN
G2CDB.HUMAN_MGLUR5
g2cdb.human_synaptosom
CompositeSet
Darnell FMRP targets
Ascano FMRP targets
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：COOCCUR High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字命中：1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 耶和华 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS16899493 CHR5 71836880 MAP1B 4131 0.04 顺式
SNP_A-2040925 0 MAP1B 4131 0.03 反式
rs11122162 CHR1 231097041 MAP1B 4131 0.06 反式
rs16843810 CHR1 234827318 MAP1B 4131 0.05 反式
rs11127467 CHR2 12993 MAP1B 4131 0 反式
rs17040095 CHR2 65926994 MAP1B 4131 0.17 反式
RS9813119 CHR3 45230566 MAP1B 4131 0.02 反式
RS192095 CHR3 111821862 MAP1B 4131 0.13 反式
RS16830299 CHR3 159090973 MAP1B 4131 0.16 反式
rs4698397 CHR4 15534712 MAP1B 4131 2.682E-5 反式
RS16992737 CHR4 36849942 MAP1B 4131 0.02 反式
rs17270544 CHR4 182529568 MAP1B 4131 4.888E-4 反式
rs17211786 CHR4 182548238 MAP1B 4131 2.69E-4 反式
RS2434733 CHR5 154431911 MAP1B 4131 0.01 反式
rs1494142 CHR6 125778157 MAP1B 4131 0.15 反式
rs6937122 CHR6 143694842 MAP1B 4131 0.03 反式
rs7760371 CHR6 143712251 MAP1B 4131 0.02 反式
RS17081113 CHR6 151637449 MAP1B 4131 0.08 反式
rs12112911 CHR7 26297444 MAP1B 4131 0.1 反式
RS868269 CHR7 76007808 MAP1B 4131 0.12 反式
rs7817138 CHR8 111140526 MAP1B 4131 0.04 反式
rs10505136 CHR8 111141220 MAP1B 4131 0.04 反式
RS4743895 CHR9 95905749 MAP1B 4131 0.19 反式
rs16919567 CHR9 103624176 MAP1B 4131 0.04 反式
RS7864609 CHR9 117884215 MAP1B 4131 0 反式
RS10818070 CHR9 120456494 MAP1B 4131 0.17 反式
RS7864330 CHR9 120469549 MAP1B 4131 0.08 反式
rs7087570 CHR10 19940964 MAP1B 4131 0.03 反式
rs7910314 CHR10 56004456 MAP1B 4131 0.03 反式
rs1236903 CHR10 71198993 MAP1B 4131 0.16 反式
rs3740184 CHR10 127356543 MAP1B 4131 0.16 反式
RS1436802 CHR10 128204332 MAP1B 4131 0.12 反式
RS1036454 CHR10 128211573 MAP1B 4131 0.11 反式
rs766095 CHR12 1498432 MAP1B 4131 0.01 反式
RS7135241 CHR12 95163565 MAP1B 4131 0 反式
rs11110940 CHR12 102054842 MAP1B 4131 0.02 反式
rs11110942 CHR12 102055094 MAP1B 4131 0.09 反式
RS10860768 CHR12 102069497 MAP1B 4131 0 反式
rs12230291 CHR12 102100263 MAP1B 4131 3.336E-4 反式
snp_a-4249110 0 MAP1B 4131 3.336E-4 反式
RS11111009 CHR12 102160626 MAP1B 4131 3.336E-4 反式
RS10860798 CHR12 102251472 MAP1B 4131 0.12 反式
rs17032130 CHR12 102331171 MAP1B 4131 3.336E-4 反式
rs17032134 CHR12 102331946 MAP1B 4131 3.336E-4 反式
RS11111120 CHR12 102389007 MAP1B 4131 0.06 反式
rs16944815 CHR13 91474365 MAP1B 4131 0.05 反式
snp_a-2171858 0 MAP1B 4131 0.05 反式
RS11842059 CHR13 91553390 MAP1B 4131 0.01 反式
rs17117421 CHR14 47008315 MAP1B 4131 0.17 反式
RS17127700 CHR14 55115256 MAP1B 4131 0.02 反式
SNP_A-1912511 0 MAP1B 4131 8.696E-4 反式
RS7224708 CHR17 75782838 MAP1B 4131 0.01 反式
rs6096615 CHR20 50472392 MAP1B 4131 4.318E-4 反式
rs16999646 CHR21 25544091 MAP1B 4131 0.05 反式
RS455633 CHR21 28170785 MAP1B 4131 0.14 反式
RS464273 CHR21 28171591 MAP1B 4131 0.14 反式
RS229080 CHR21 28192989 MAP1B 4131 0.07 反式
rs2837968 CHR21 42586603 MAP1B 4131 0.15 反式
rs7887792 Chrx 20508216 MAP1B 4131 0.01 反式
rs7061383 Chrx 32937380 MAP1B 4131 7.338e-4 反式
rs17174152 Chrx 70403143 MAP1B 4131 0.01 反式
rs16980072 Chrx 84311360 MAP1B 4131 8.182E-4 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26后概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 12147674
去：0005198 structural molecule activity nas 1881920
生物过程 去学期 证据 神经关键字 PubMed ID
去：0016358 dendrite development IEA 神经突，树突（GO期限：11） -
去：0001578 microtubule bundle formation IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 细胞质 IEA -
去：0005874 microtubule IEA -
去：0005875 microtubule associated complex TAS 1881920

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ANP32A C15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A - HPRD,BioGRID 12807913
Dynll1 DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1 Dynein，轻链，LC8型1 - HPRD 14760703
FMR1 FMRP | FRAXA | MGC87458 | POF | POF1 fragile X mental retardation 1 FMR1(FMRP) interacts with MAP1B mRNA. This interaction was modeled on a demonstrated interaction between FMR1 from an unspecified species and human MAP1B mRNA. 绑定 15381419
GABRR1 MGC163216 γ-氨基丁酸（GABA）受体，Rho 1 - HPRD 9892354|11102469
GABRR2 - γ-氨基丁酸（GABA）受体，Rho 2 - HPRD 11102469
GAN FLJ38059 |gan1 |KLHL16 gigaxonin - HPRD,BioGRID 12147674
杂志 GMA |S-MAG |SIGLEC-4A |siglec4a myelin associated glycoprotein - HPRD,BioGRID 11733546
map1a FLJ77111 |map1l |mtap1a microtubule-associated protein 1A - HPRD,BioGRID 2470876|11002287
MAPK8 JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 有丝分裂原激活的蛋白激酶8 - HPRD 12689591
RASSF1 123F2 | NORE2A | RASSF1A | RDA32 | REH3P21 Ras association (RalGDS/AF-6) domain family member 1 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 15205320
SNCA MGC110988 |NACP |park1 |park4 |PD1 synuclein, alpha (non A4 component of amyloid precursor) - HPRD,BioGRID 10764738


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PC12细胞中的ST分化途径 45 35 All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY 29 29 All SZGR 2.0 genes in this pathway
PID Netrin途径 32 27 All SZGR 2.0 genes in this pathway
PID LIS1途径 28 22 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
Sengupta鼻咽癌和LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 50 36 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
Basaki YBX1靶向 290 177 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP 79 50 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 43 29 All SZGR 2.0 genes in this pathway
IGF1和IGF2的Pacher靶标 35 27 All SZGR 2.0 genes in this pathway
冷吉非替尼抵抗 85 57 All SZGR 2.0 genes in this pathway
血清剥夺DN的Graessmann凋亡 234 147 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
Tang衰老TP53靶向DN 57 33 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN 483 336 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193 112 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
狮子转移 539 324 All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向 292 168 All SZGR 2.0 genes in this pathway
WU细胞迁移 184 114 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 83 58 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL UP 39 22 All SZGR 2.0 genes in this pathway
切斯勒大脑最高遗传差异 37 21 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 144 98 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1 vs CD2向上 66 47 All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN 30 21 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
Ramaswamy转移DN 61 47 All SZGR 2.0 genes in this pathway
lindvall被tert dn永生 80 56 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D2 41 30 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
Cheng对醋酸镍的反应 45 29 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
Lein本地化为近端树突 37 26 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
Heller被甲基化DN沉默 105 67 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
Smid乳腺癌Luminal B DN 564 326 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向成纤维细胞 84 60 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1 237 159 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR DN 36 19 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化 121 70 All SZGR 2.0 genes in this pathway
BMI1和PCGF2的Wiederschain目标 57 39 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移1 46 33 All SZGR 2.0 genes in this pathway
Plasari TGFB1通过NFIC 1小时DN信号传导 106 77 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway

第六节microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-124.1 937 943 M8 HSA-MIR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 937 943 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-143 240 246 M8 HSA-MIR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-181 954 961 1A，M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 1181 1187 1A HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
mir-223 282 288 M8 HSA-MIR-223 ugucuuugucaauacccc
mir-224 948 954 M8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-26 951 957 1A HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ Uucaaguaauucaggauagguu
miR-493-5p 957 964 1A，M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
mir-9 902 908 M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
mir-93.hd/291-3p/294/295/302/372/373/520 976 982 1A hsa-miR-93brain aaagugcuguucgugcagguag
hsa-miR-302a Uaagugcuauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 gagugcuucgauuuggggugu
HSA-MIR-520E aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuagaggg
hsa-miR-520c aaagugcuuuuuagagggUU
hsa-miR-520d aaaguguuguguggguggguu