Gene Page:MAP2

Summary?
GeneID 4133
Symbol MAP2
Synonyms MAP2A|MAP2B|MAP2C
Description microtubule associated protein 2
Reference MIM:157130|HGNC:HGNC:6839|Ensembl:ENSG00000078018|HPRD:01140|Vega:OTTHUMG00000132962
Gene type protein-coding
Map location 2q34-q35
Pascal p-value 0.032
Fetal beta 0.579
eGene Myers' cis & trans
Support STRUCTURAL PLASTICITY
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_mGluR5
G2Cdb.humanNRC
CompositeSet
Darnell FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 1.2138

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs235427 chr8 133815575 MAP2 4133 0.17 trans
rs7894597 chr10 9384581 MAP2 4133 0.03 trans
rs1324669 chr13 107872446 MAP2 4133 0.16 trans
rs17188417 chr14 90517901 MAP2 4133 0.2 trans
rs6098023 chr20 53113740 MAP2 4133 0.17 trans
rs17145698 chrX 40218345 MAP2 4133 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
GO:0005516 calmodulin binding IEA -
GO:0005198 structural molecule activity NAS 9588626
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007026 negative regulation of microtubule depolymerization IEA -
GO:0008150 biological_process ND -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton IEA -
GO:0005874 microtubule IEA -
GO:0005875 microtubule associated complex NAS 7854050
GO:0005875 microtubule associated complex TAS 9588626
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
APOE AD2 | LPG | MGC1571 | apoprotein apolipoprotein E - HPRD 8624078
CPEB1 CEBP | CPE-BP1 | CPEB | FLJ13203 | MGC34136 | MGC60106 cytoplasmic polyadenylation element binding protein 1 - HPRD 12629046
FYN MGC45350 | SLK | SYN FYN oncogene related to SRC, FGR, YES Affinity Capture-Western BioGRID 11546790
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 10781592|11546790|11546790
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 10862698
GRIN2D EB11 | NMDAR2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D - HPRD 10862698
MAP2 DKFZp686I2148 | MAP2A | MAP2B | MAP2C microtubule-associated protein 2 - HPRD,BioGRID 10527895
MARK4 FLJ90097 | KIAA1860 | MARKL1 | Nbla00650 MAP/microtubule affinity-regulating kinase 4 - HPRD,BioGRID 14594945
MYO7A DFNA11 | DFNB2 | MYOVIIA | MYU7A | NSRD2 | USH1B myosin VIIA - HPRD,BioGRID 11171103
NEFL CMT1F | CMT2E | FLJ53642 | NF-L | NF68 | NFL neurofilament, light polypeptide Reconstituted Complex BioGRID 1902666
PLEC1 EBS1 | EBSO | HD1 | PCN | PLEC1b | PLTN plectin 1, intermediate filament binding protein 500kDa - HPRD,BioGRID 3027087
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Reconstituted Complex BioGRID 10781592
TTBK1 BDTK | KIAA1855 | RP3-330M21.4 tau tubulin kinase 1 - HPRD 7556643


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA AKAPCENTROSOME PATHWAY 15 14 All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN 77 52 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP 21 15 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 81 52 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 37 26 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL 61 47 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP 45 28 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 68 45 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 44 34 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP 139 93 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS SKIN UP 38 27 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
由1日EGF ZWANG瞬变脉冲 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 3477 3483 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-139 121 127 m8 hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-141/200a 481 487 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-17-5p/20/93.mr/106/519.d 658 664 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-186 82 89 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-194 3589 3595 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-200bc/429 264 270 1A hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-214 2922 2929 1A,m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-23 893 899 1A hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-26 822 829 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-30-5p 1115 1121 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-335 43 49 m8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-338 3515 3521 m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-361 3572 3579 1A,m8 hsa-miR-361brain UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p 265 271 m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 764 770 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-381 490 496 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-450 3477 3483 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-496 457 463 m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-539 788 794 m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-544 167 174 1A,m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU