Gene Page:MAPT
概括?
GeneID | 4137 |
象征 | MAPT |
Synonyms | DDPAC|FTDP-17|MAPTL|MSTD|MTBT1|MTBT2|PPND|PPP1R103|TAU |
Description | 微管相关蛋白tau |
Reference | MIM:157140|HGNC:HGNC:6893|ENSEMBL:ENSG00000186868|HPRD:01142|Vega:OTTHUMG00000168833 |
基因类型 | protein-coding |
Map location | 17q21.1 |
Sherlock P值 | 0.004 |
Fetal beta | -2.487 |
eGene | Cerebellar Hemisphere 小脑 皮质 额叶皮质BA9 迈尔斯的顺式和跨性别 Meta |
Support | 结构可塑性 G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet 潜在的突触基因 |
数据源中的基因
基因集名称 | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
简历:Phewas | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
PMID:cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
Literature | High-throughput literature-search | 与精神分裂症关键词共同存在:精神分裂症,精神分裂症,精神分裂症 | 点击to show details |
GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关关键字的命中:8 | |
Network | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | 贡献在PPI网络最短路径:3.6916 |
第一节遗传学和表观遗传学注释
简历:Phewas
SNP ID | 染色体 | 位置 | Allele | P | Function | Gene | 向上/向下距离 |
---|---|---|---|---|---|---|---|
rs242557 | 17 | 0 | 无效的 | 1.576 | MAPT | 无效的 |
eQTL annotation
SNP ID | 染色体 | 位置 | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
RS12947718 | chr17 | 43493100 | MAPT | 4137 | 0 | cis | ||
rs17631303 | chr17 | 43516401 | MAPT | 4137 | 0 | cis | ||
rs3946526 | chr17 | 43541655 | MAPT | 4137 | 1.764E-4 | cis | ||
rs2696425 | chr17 | 43666905 | MAPT | 4137 | 8.37E-4 | cis | ||
rs418891 | chr17 | 43693537 | MAPT | 4137 | 0 | cis | ||
RS413778 | chr17 | 43716884 | MAPT | 4137 | 0 | cis | ||
rs453997 | chr17 | 43727060 | MAPT | 4137 | 5.899E-4 | cis | ||
rs422112 | chr17 | 43728136 | MAPT | 4137 | 0 | cis | ||
rs241033 | chr17 | 43733982 | MAPT | 4137 | 5.899E-4 | cis | ||
rs241032 | chr17 | 43734144 | MAPT | 4137 | 0 | cis | ||
rs241031 | chr17 | 43734303 | MAPT | 4137 | 5.899E-4 | cis | ||
rs17760733 | chr17 | 43746275 | MAPT | 4137 | 0.01 | cis | ||
rs17687571 | chr17 | 43750009 | MAPT | 4137 | 0 | cis | ||
RS17687667 | chr17 | 43754098 | MAPT | 4137 | 6.42E-4 | cis | ||
rs17688002 | chr17 | 43762593 | MAPT | 4137 | 5.899E-4 | cis | ||
RS17688068 | chr17 | 43763934 | MAPT | 4137 | 0.02 | cis | ||
RS17688391 | chr17 | 43772108 | MAPT | 4137 | 9.156E-4 | cis | ||
rs17688434 | chr17 | 43772539 | MAPT | 4137 | 0 | cis | ||
RS12150610 | chr17 | 43775478 | MAPT | 4137 | 0 | cis | ||
RS12150547 | chr17 | 43775545 | MAPT | 4137 | 5.899E-4 | cis | ||
RS17762165 | chr17 | 43778601 | MAPT | 4137 | 8.734E-4 | cis | ||
rs17688922 | chr17 | 43779350 | MAPT | 4137 | 0 | cis | ||
rs17688944 | chr17 | 43779418 | MAPT | 4137 | 5.878E-4 | cis | ||
RS1526128 | chr17 | 43779623 | MAPT | 4137 | 7.6E-4 | cis | ||
RS1526129 | chr17 | 43779656 | MAPT | 4137 | 0 | cis | ||
RS1724425 | chr17 | 43781746 | MAPT | 4137 | 0.01 | cis | ||
rs17563501 | chr17 | 43801694 | MAPT | 4137 | 7.043E-4 | cis | ||
rs2902662 | chr17 | 43806924 | MAPT | 4137 | 0 | cis | ||
rs17563787 | chr17 | 43813251 | MAPT | 4137 | 5.878E-4 | cis | ||
RS17563827 | chr17 | 43818221 | MAPT | 4137 | 7.176E-4 | cis | ||
rs12150672 | chr17 | 43826636 | MAPT | 4137 | 0.01 | cis | ||
rs17426106 | chr17 | 43828934 | MAPT | 4137 | 5.452E-4 | cis | ||
rs17426195 | chr17 | 43832366 | MAPT | 4137 | 7.513E-4 | cis | ||
RS6503447 | chr17 | 43834911 | MAPT | 4137 | 0.06 | cis | ||
RS4074462 | chr17 | 43855227 | MAPT | 4137 | 0 | cis | ||
RS17689471 | chr17 | 43892972 | MAPT | 4137 | 7.043E-4 | cis | ||
RS17762769 | chr17 | 43893402 | MAPT | 4137 | 0 | cis | ||
rs171440 | chr17 | 43893486 | MAPT | 4137 | 0.08 | cis | ||
RS8072451 | chr17 | 43893715 | MAPT | 4137 | 0 | cis | ||
RS4277389 | chr17 | 43895652 | MAPT | 4137 | 5.878E-4 | cis | ||
RS17689824 | chr17 | 43904396 | MAPT | 4137 | 6.987E-4 | cis | ||
RS17763086 | chr17 | 43905480 | MAPT | 4137 | 0.02 | cis | ||
RS17689882 | chr17 | 43906827 | MAPT | 4137 | 5.878E-4 | cis | ||
rs17769552 | chr17 | 43927289 | MAPT | 4137 | 9.779E-4 | cis | ||
rs916793 | chr17 | 43954685 | MAPT | 4137 | 7.043E-4 | cis | ||
rs17649553 | chr17 | 43994647 | MAPT | 4137 | 0 | cis | ||
rs17649641 | chr17 | 43997371 | MAPT | 4137 | 0 | cis | ||
rs17564223 | chr17 | 43997519 | MAPT | 4137 | 0 | cis | ||
rs17649954 | chr17 | 44001660 | MAPT | 4137 | 5.441E-4 | cis | ||
rs17564619 | chr17 | 44002137 | MAPT | 4137 | 9.354E-4 | cis | ||
rs17650063 | chr17 | 44002554 | MAPT | 4137 | 7.043E-4 | cis | ||
RS17564780 | chr17 | 44005412 | MAPT | 4137 | 7.043E-4 | cis | ||
RS17650381 | chr17 | 44013023 | MAPT | 4137 | 0 | cis | ||
RS12150111 | chr17 | 44013937 | MAPT | 4137 | 7.043E-4 | cis | ||
RS2316784 | chr17 | 44021698 | MAPT | 4137 | 8.505E-4 | cis | ||
rs4327091 | chr17 | 44021716 | MAPT | 4137 | 5.878E-4 | cis | ||
rs242559 | chr17 | 44025887 | MAPT | 4137 | 0 | cis | ||
rs17571718 | chr17 | 44032767 | MAPT | 4137 | 4.555E-4 | cis | ||
rs17571739 | chr17 | 44032914 | MAPT | 4137 | 5.878E-4 | cis | ||
rs17650872 | chr17 | 44039515 | MAPT | 4137 | 7.043E-4 | cis | ||
RS17572169 | chr17 | 44045973 | MAPT | 4137 | 5.878E-4 | cis | ||
RS17651213 | chr17 | 44051923 | MAPT | 4137 | 0.01 | cis | ||
RS17572361 | chr17 | 44052008 | MAPT | 4137 | 0 | cis | ||
rs17572851 | chr17 | 44063765 | MAPT | 4137 | 0 | cis | ||
rs17572893 | chr17 | 44064207 | MAPT | 4137 | 5.878E-4 | cis | ||
rs17573175 | chr17 | 44071088 | MAPT | 4137 | 8.2e-4 | cis | ||
rs1078268 | chr17 | 44075900 | MAPT | 4137 | 0 | cis | ||
RS8070723 | chr17 | 44081063 | MAPT | 4137 | 5.878E-4 | cis | ||
rs17652449 | chr17 | 44088936 | MAPT | 4137 | 0 | cis | ||
rs17652502 | chr17 | 44094470 | MAPT | 4137 | 7.043E-4 | cis | ||
rs17574228 | chr17 | 44104508 | MAPT | 4137 | 5.878E-4 | cis | ||
RS1076222 | chr17 | 44109768 | MAPT | 4137 | 0 | cis | ||
RS7350980 | chr17 | 44110270 | MAPT | 4137 | 0 | cis | ||
rs4597358 | chr17 | 44110669 | MAPT | 4137 | 5.878E-4 | cis | ||
rs17653162 | chr17 | 44111826 | MAPT | 4137 | 3.466E-4 | cis | ||
rs17574824 | chr17 | 44115106 | MAPT | 4137 | 0 | cis | ||
rs12150090 | chr17 | 44115885 | MAPT | 4137 | 7.043E-4 | cis | ||
rs7221390 | chr17 | 44116949 | MAPT | 4137 | 7.043E-4 | cis | ||
rs17575556 | chr17 | 44135826 | MAPT | 4137 | 8.802E-4 | cis | ||
rs17659881 | chr17 | 44157596 | MAPT | 4137 | 7.043E-4 | cis | ||
rs17660132 | chr17 | 44165802 | MAPT | 4137 | 3.611E-4 | cis | ||
rs17577094 | chr17 | 44187491 | MAPT | 4137 | 0 | cis | ||
rs17660907 | chr17 | 44191084 | MAPT | 4137 | 0 | cis | ||
RS8070942 | chr17 | 44208673 | MAPT | 4137 | 5.515E-4 | cis | ||
RS2532316 | chr17 | 44213711 | MAPT | 4137 | 5.878E-4 | cis | ||
rs2696600 | chr17 | 44216225 | MAPT | 4137 | 0 | cis | ||
rs1406068 | chr17 | 44234525 | MAPT | 4137 | 5.878E-4 | cis | ||
RS2532292 | chr17 | 44237067 | MAPT | 4137 | 7.043E-4 | cis | ||
RS2532286 | chr17 | 44241663 | MAPT | 4137 | 7.544e-4 | cis | ||
RS2532276 | chr17 | 44246623 | MAPT | 4137 | 0 | cis | ||
RS2532275 | chr17 | 44246996 | MAPT | 4137 | 7.043E-4 | cis | ||
rs2532259 | chr17 | 44253363 | MAPT | 4137 | 7.043E-4 | cis | ||
RS2732646 | chr17 | 44254378 | MAPT | 4137 | 5.878E-4 | cis | ||
RS2732589 | chr17 | 44266021 | MAPT | 4137 | 0 | cis | ||
rs1918788 | chr17 | 44267616 | MAPT | 4137 | 7.043E-4 | cis | ||
RS2732596 | chr17 | 44269545 | MAPT | 4137 | 0.01 | cis | ||
rs2732675 | chr17 | 44280187 | MAPT | 4137 | 0 | cis | ||
rs2732674 | chr17 | 44280696 | MAPT | 4137 | 0.01 | cis | ||
rs2668695 | chr17 | 44292125 | MAPT | 4137 | 6.7e-4 | cis | ||
RS2532332 | chr17 | 44347726 | MAPT | 4137 | 0.08 | cis | ||
rs2732706 | chr17 | 44351685 | MAPT | 4137 | 0 | cis | ||
rs2668624 | chr17 | 44352871 | MAPT | 4137 | 0.01 | cis | ||
rs199436 | chr17 | 44789284 | MAPT | 4137 | 0.17 | cis | ||
rs142167 | chr17 | 44795233 | MAPT | 4137 | 0.12 | cis | ||
rs199452 | chr17 | 44801339 | MAPT | 4137 | 0.13 | cis | ||
rs199449 | chr17 | 44808901 | MAPT | 4137 | 0.15 | cis | ||
rs199535 | chr17 | 44822661 | MAPT | 4137 | 0.04 | cis | ||
RS199515 | chr17 | 44856640 | MAPT | 4137 | 0.1 | cis | ||
RS12947718 | chr17 | 43493100 | MAPT | 4137 | 0.17 | 反式 | ||
rs17631303 | chr17 | 43516401 | MAPT | 4137 | 0.1 | 反式 | ||
rs3946526 | chr17 | 43541655 | MAPT | 4137 | 0.02 | 反式 | ||
rs2696425 | chr17 | 43666905 | MAPT | 4137 | 0.06 | 反式 | ||
rs418891 | chr17 | 43693537 | MAPT | 4137 | 0.17 | 反式 | ||
RS413778 | chr17 | 43716884 | MAPT | 4137 | 0.13 | 反式 | ||
rs453997 | chr17 | 43727060 | MAPT | 4137 | 0.05 | 反式 | ||
rs422112 | chr17 | 43728136 | MAPT | 4137 | 0.13 | 反式 | ||
rs241033 | chr17 | 43733982 | MAPT | 4137 | 0.05 | 反式 | ||
rs241031 | chr17 | 43734303 | MAPT | 4137 | 0.05 | 反式 | ||
rs17687571 | chr17 | 43750009 | MAPT | 4137 | 0.18 | 反式 | ||
RS17687667 | chr17 | 43754098 | MAPT | 4137 | 0.05 | 反式 | ||
rs17688002 | chr17 | 43762593 | MAPT | 4137 | 0.05 | 反式 | ||
RS17688391 | chr17 | 43772108 | MAPT | 4137 | 0.07 | 反式 | ||
rs17688434 | chr17 | 43772539 | MAPT | 4137 | 0.11 | 反式 | ||
RS12150610 | chr17 | 43775478 | MAPT | 4137 | 0.1 | 反式 | ||
RS12150547 | chr17 | 43775545 | MAPT | 4137 | 0.05 | 反式 | ||
RS17762165 | chr17 | 43778601 | MAPT | 4137 | 0.06 | 反式 | ||
rs17688922 | chr17 | 43779350 | MAPT | 4137 | 0.07 | 反式 | ||
rs17688944 | chr17 | 43779418 | MAPT | 4137 | 0.05 | 反式 | ||
RS1526128 | chr17 | 43779623 | MAPT | 4137 | 0.06 | 反式 | ||
RS1526129 | chr17 | 43779656 | MAPT | 4137 | 0.08 | 反式 | ||
rs17563501 | chr17 | 43801694 | MAPT | 4137 | 0.05 | 反式 | ||
rs2902662 | chr17 | 43806924 | MAPT | 4137 | 0.1 | 反式 | ||
rs17563787 | chr17 | 43813251 | MAPT | 4137 | 0.05 | 反式 | ||
RS17563827 | chr17 | 43818221 | MAPT | 4137 | 0.05 | 反式 | ||
rs17426106 | chr17 | 43828934 | MAPT | 4137 | 0.04 | 反式 | ||
rs17426195 | chr17 | 43832366 | MAPT | 4137 | 0.06 | 反式 | ||
RS4074462 | chr17 | 43855227 | MAPT | 4137 | 0.09 | 反式 | ||
RS17689471 | chr17 | 43892972 | MAPT | 4137 | 0.05 | 反式 | ||
RS17762769 | chr17 | 43893402 | MAPT | 4137 | 0.1 | 反式 | ||
RS8072451 | chr17 | 43893715 | MAPT | 4137 | 0.08 | 反式 | ||
RS4277389 | chr17 | 43895652 | MAPT | 4137 | 0.05 | 反式 | ||
RS17689824 | chr17 | 43904396 | MAPT | 4137 | 0.05 | 反式 | ||
rs17769552 | chr17 | 43927289 | MAPT | 4137 | 0.07 | 反式 | ||
snp_a-2150382 | 0 | MAPT | 4137 | 0.04 | 反式 | |||
rs916793 | chr17 | 43954685 | MAPT | 4137 | 0.05 | 反式 | ||
rs17649553 | chr17 | 43994647 | MAPT | 4137 | 0.09 | 反式 | ||
rs17649641 | chr17 | 43997371 | MAPT | 4137 | 0.17 | 反式 | ||
rs17564223 | chr17 | 43997519 | MAPT | 4137 | 0.09 | 反式 | ||
rs17649954 | chr17 | 44001660 | MAPT | 4137 | 0.04 | 反式 | ||
rs17564619 | chr17 | 44002137 | MAPT | 4137 | 0.07 | 反式 | ||
rs17650063 | chr17 | 44002554 | MAPT | 4137 | 0.05 | 反式 | ||
RS17564780 | chr17 | 44005412 | MAPT | 4137 | 0.05 | 反式 | ||
RS17650381 | chr17 | 44013023 | MAPT | 4137 | 0.11 | 反式 | ||
RS12150111 | chr17 | 44013937 | MAPT | 4137 | 0.05 | 反式 | ||
RS2316784 | chr17 | 44021698 | MAPT | 4137 | 0.06 | 反式 | ||
rs4327091 | chr17 | 44021716 | MAPT | 4137 | 0.05 | 反式 | ||
rs242559 | chr17 | 44025887 | MAPT | 4137 | 0.08 | 反式 | ||
rs17571718 | chr17 | 44032767 | MAPT | 4137 | 0.04 | 反式 | ||
rs17571739 | chr17 | 44032914 | MAPT | 4137 | 0.05 | 反式 | ||
rs17650872 | chr17 | 44039515 | MAPT | 4137 | 0.05 | 反式 | ||
RS17572169 | chr17 | 44045973 | MAPT | 4137 | 0.05 | 反式 | ||
RS17572361 | chr17 | 44052008 | MAPT | 4137 | 0.18 | 反式 | ||
rs17572851 | chr17 | 44063765 | MAPT | 4137 | 0.1 | 反式 | ||
rs17572893 | chr17 | 44064207 | MAPT | 4137 | 0.05 | 反式 | ||
rs17573175 | chr17 | 44071088 | MAPT | 4137 | 0.06 | 反式 | ||
rs1078268 | chr17 | 44075900 | MAPT | 4137 | 0.09 | 反式 | ||
RS8070723 | chr17 | 44081063 | MAPT | 4137 | 0.05 | 反式 | ||
rs17652449 | chr17 | 44088936 | MAPT | 4137 | 0.15 | 反式 | ||
rs17652502 | chr17 | 44094470 | MAPT | 4137 | 0.05 | 反式 | ||
rs17574228 | chr17 | 44104508 | MAPT | 4137 | 0.05 | 反式 | ||
RS1076222 | chr17 | 44109768 | MAPT | 4137 | 0.09 | 反式 | ||
RS7350980 | chr17 | 44110270 | MAPT | 4137 | 0.08 | 反式 | ||
rs4597358 | chr17 | 44110669 | MAPT | 4137 | 0.05 | 反式 | ||
rs17653162 | chr17 | 44111826 | MAPT | 4137 | 0.03 | 反式 | ||
rs17574824 | chr17 | 44115106 | MAPT | 4137 | 0.2 | 反式 | ||
rs12150090 | chr17 | 44115885 | MAPT | 4137 | 0.05 | 反式 | ||
SNP_A-1855473 | 0 | MAPT | 4137 | 0.05 | 反式 | |||
rs7221390 | chr17 | 44116949 | MAPT | 4137 | 0.05 | 反式 | ||
SNP_A-1823652 | 0 | MAPT | 4137 | 0.18 | 反式 | |||
rs17575556 | chr17 | 44135826 | MAPT | 4137 | 0.06 | 反式 | ||
rs17659881 | chr17 | 44157596 | MAPT | 4137 | 0.05 | 反式 | ||
rs17660132 | chr17 | 44165802 | MAPT | 4137 | 0.03 | 反式 | ||
rs17577094 | chr17 | 44187491 | MAPT | 4137 | 0.15 | 反式 | ||
rs17660907 | chr17 | 44191084 | MAPT | 4137 | 0.07 | 反式 | ||
RS8070942 | chr17 | 44208673 | MAPT | 4137 | 0.04 | 反式 | ||
RS2532316 | chr17 | 44213711 | MAPT | 4137 | 0.05 | 反式 | ||
rs2696600 | chr17 | 44216225 | MAPT | 4137 | 0.13 | 反式 | ||
rs1406068 | chr17 | 44234525 | MAPT | 4137 | 0.05 | 反式 | ||
RS2532292 | chr17 | 44237067 | MAPT | 4137 | 0.05 | 反式 | ||
RS2532286 | chr17 | 44241663 | MAPT | 4137 | 0.06 | 反式 | ||
RS2532276 | chr17 | 44246623 | MAPT | 4137 | 0.07 | 反式 | ||
RS2532275 | chr17 | 44246996 | MAPT | 4137 | 0.05 | 反式 | ||
rs2532259 | chr17 | 44253363 | MAPT | 4137 | 0.05 | 反式 | ||
RS2732646 | chr17 | 44254378 | MAPT | 4137 | 0.05 | 反式 | ||
RS2732589 | chr17 | 44266021 | MAPT | 4137 | 0.16 | 反式 | ||
rs1918788 | chr17 | 44267616 | MAPT | 4137 | 0.05 | 反式 | ||
rs2732675 | chr17 | 44280187 | MAPT | 4137 | 0.14 | 反式 | ||
rs2668695 | chr17 | 44292125 | MAPT | 4137 | 0.05 | 反式 | ||
rs2732706 | chr17 | 44351685 | MAPT | 4137 | 0.11 | 反式 | ||
rs2668622 | 0 | MAPT | 4137 | 0.04 | 反式 |
Section II. Transcriptome annotation
General gene expression (GTEx)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/MAPT_DE_GTEx.png)
Devlopment期间的基因表达(BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
大脑区域的顶级共表达基因
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
TNS1 | 0.83 | 0.86 |
TLN1 | 0.80 | 0.81 |
RRBP1 | 0.79 | 0.83 |
SLC20A2 | 0.78 | 0.82 |
GSN | 0.77 | 0.78 |
angptl2 | 0.77 | 0.79 |
TJP2 | 0.77 | 0.82 |
UNC5B | 0.77 | 0.80 |
MYLK | 0.77 | 0.79 |
ERBB3 | 0.77 | 0.77 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
NR2C2AP | -0.53 | -0.56 |
RPL27 | -0.52 | -0.67 |
RPL31 | -0.52 | -0.66 |
POLB | -0.52 | -0.58 |
RPS23 | -0.52 | -0.66 |
FRG1 | -0.52 | -0.61 |
RPL24 | -0.52 | -0.68 |
CYP2R1 | -0.52 | -0.57 |
RPS18 | -0.52 | -0.64 |
RPL32 | -0.51 | -0.64 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
去:0005200 | structural constituent of cytoskeleton | 塔斯 | 2498079 | |
GO:0008034 | 脂蛋白结合 | IPI | 7972031 | |
GO:0017124 | SH3域结合 | IPI | 9763511 | |
GO:0008017 | 微管结合 | IDA | 1918161 | |
GO:0008017 | 微管结合 | ISS | - | |
GO:0019899 | enzyme binding | IPI | 9736630|12888622 | |
GO:0034187 | 载脂蛋白ebinding | IPI | 7566652 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0048699 | generation of neurons | nas | neuron, neurogenesis (GO term level: 7) | 8522593 |
GO:0045773 | positive regulation of axon extension | IDA | axon (GO term level: 15) | 1389180 |
GO:0045773 | positive regulation of axon extension | ISS | axon (GO term level: 15) | - |
GO:0000226 | microtubule cytoskeleton organization | IDA | 1057175 | |
GO:0000226 | microtubule cytoskeleton organization | ISS | - | |
GO:0007026 | negative regulation of microtubule depolymerization | IEA | - | |
GO:0031116 | positive regulation of microtubule polymerization | IDA | 1421571 | |
GO:0031116 | positive regulation of microtubule polymerization | ISS | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0042995 | cell projection | IEA | Axon(GO术语级别:4) | - |
GO:0030426 | 生长锥 | IDA | axon, dendrite (GO term level: 5) | 8642405 |
GO:0030426 | 生长锥 | ISS | axon, dendrite (GO term level: 5) | - |
GO:0030424 | axon | IDA | neuron, axon, Neurotransmitter (GO term level: 6) | 8642405 |
GO:0030424 | axon | ISS | neuron, axon, Neurotransmitter (GO term level: 6) | - |
GO:0005829 | 细胞质 | 塔斯 | 10747907 | |
去:0005856 | cytoskeleton | IEA | - | |
去:0005875 | microtubule associated complex | 塔斯 | 10747907 | |
GO:0005737 | cytoplasm | IEA | - | |
去:0005886 | plasma membrane | IDA | 8522593 | |
去:0005886 | plasma membrane | ISS | - | |
GO:0045298 | tubulin complex | IDA | 8642405 | |
GO:0045298 | tubulin complex | ISS | - |
第四节。蛋白质蛋白相互作用注释
互动者 | 别名b | 官方全名b | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
AATF | Che-1 |che1 |ded | apoptosis antagonizing transcription factor | - | HPRD,BioGRID | 14697667 |
APOE | ad2 |LPG |MGC1571 |载蛋白 | 载脂蛋白e | Reconstituted Complex | BioGRID | 8620924 |
APOE | ad2 |LPG |MGC1571 |载蛋白 | 载脂蛋白e | - | HPRD | 7566652|9147408 |
CALM1 | CALML2 | CAMI | DD132 | PHKD | 钙调蛋白1(磷酸化酶激酶,三角洲) | - | HPRD,BioGRID | 2123288 |
FYN | MGC45350 | SLK | SYN | Fyn Oncogene与SRC,FGR,是的 | - | HPRD,BioGRID | 11826099 |
GSK3B | - | glycogen synthase kinase 3 beta | GSK3beta phosphorylates Ftau.This interaction was modelled on a demonstrated interaction between rabbit GSK3beta and human Ftau. | 绑定 | 14636947 |
MARK4 | FLJ90097 | KIAA1860 | MARKL1 | Nbla00650 | 地图/微管亲和调节激酶4 | - | HPRD,BioGRID | 14594945 |
OGT | FLJ23071 |HRNT1 |MGC22921 |O-GLCNAC | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | - | HPRD,BioGRID | 8910513|12911634 |
PIN1 | 国防部|UBL5 | 肽基丙基顺式/反式异构酶,NIMA相互作用1 | - | HPRD,BioGRID | 10391244 |
PSEN1 | AD3粉|足总D | PS1 | S182 | Presenilin 1 | - | HPRD,BioGRID | 9689133 |
S100B | nef |S100 |S100beta | S100 calcium binding protein B | - | HPRD | 11264299 |
S100B | nef |S100 |S100beta | S100 calcium binding protein B | - | HPRD,BioGRID | 2833519 |
SNCA | MGC110988 |NACP |park1 |park4 |PD1 | synuclein, alpha (non A4 component of amyloid precursor) | - | HPRD,BioGRID | 10464279 |
SPTB | HSpTB1 | 光谱,β,红细胞 | - | HPRD,BioGRID | 6743699 |
STXBP1 | EIEE4 | MUNC18-1 | UNC18 | hUNC18 | rbSec1 | syntaxin binding protein 1 | - | HPRD,BioGRID | 12963086 |
tubb2a | TUBB | TUBB2 | dJ40E16.7 | tubulin, beta 2A | - | HPRD | 9922135 |
USP9Y | AZF | AZF1 | AZFA | DFFRY | FLJ33043 | SP3 | ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila) | - | HPRD,BioGRID | 1723470 |
ywhaa | - | 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白,α多肽 | Affinity Capture-Western | BioGRID | 12176984 |
ywhab | GW128 | HS1 | KCIP-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | - | HPRD,BioGRID | 10840038 |
ywhaz | KCIP-1 |MGC111427 |MGC126532 |MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | Tau interacts with 14-3-3-zeta. | 绑定 | 12176984 |
ywhaz | KCIP-1 |MGC111427 |MGC126532 |MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | - | HPRD,BioGRID | 10840038 |
V.途径注释
路径名 | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG MAPK SIGNALING PATHWAY | 267 | 205 | 该途径中的所有SZGR 2.0基因 |
KEGG ALZHEIMERS DISEASE | 169 | 110 | 该途径中的所有SZGR 2.0基因 |
BIOCARTA BIOPEPTIDES PATHWAY | 45 | 35 | 该途径中的所有SZGR 2.0基因 |
BIOCARTA P35ALZHEIMERS PATHWAY | 11 | 9 | 该途径中的所有SZGR 2.0基因 |
PID溶物磷脂途径 | 66 | 53 | 该途径中的所有SZGR 2.0基因 |
PID REELIN PATHWAY | 29 | 29 | 该途径中的所有SZGR 2.0基因 |
PID LKB1 PATHWAY | 47 | 37 | 该途径中的所有SZGR 2.0基因 |
PID P38伽马三角洲途径 | 11 | 9 | 该途径中的所有SZGR 2.0基因 |
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 40 | 26 | 该途径中的所有SZGR 2.0基因 |
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | 13 | 11 | 该途径中的所有SZGR 2.0基因 |
REACTOME APOPTOSIS | 148 | 94 | 该途径中的所有SZGR 2.0基因 |
Reactome凋亡执行阶段 | 54 | 37 | 该途径中的所有SZGR 2.0基因 |
LIU SOX4 TARGETS DN | 309 | 191 | 该途径中的所有SZGR 2.0基因 |
THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | 该途径中的所有SZGR 2.0基因 |
乳腺癌腔与基础 | 380 | 215 | 该途径中的所有SZGR 2.0基因 |
DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | 该途径中的所有SZGR 2.0基因 |
DOANE BREAST CANCER ESR1 UP | 112 | 72 | 该途径中的所有SZGR 2.0基因 |
ginestier乳腺癌20q13扩增 | 119 | 66 | 该途径中的所有SZGR 2.0基因 |
阿霉素DN的Graessmann凋亡 | 1781年 | 1082 | 该途径中的所有SZGR 2.0基因 |
Gaussmann MLL AF4融合靶向G | 238 | 135 | 该途径中的所有SZGR 2.0基因 |
农民乳腺癌根源与基础 | 330 | 217 | 该途径中的所有SZGR 2.0基因 |
FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | 该途径中的所有SZGR 2.0基因 |
Schlosser血清反应 | 134 | 93 | 该途径中的所有SZGR 2.0基因 |
TERAMOTO OPN TARGETS CLUSTER 8 | 8 | 7 | 该途径中的所有SZGR 2.0基因 |
YANG BREAST CANCER ESR1 UP | 36 | 22 | 该途径中的所有SZGR 2.0基因 |
PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
BENPORATH SUZ12 TARGETS | 1038 | 678 | 该途径中的所有SZGR 2.0基因 |
Benporath EED目标 | 1062 | 725 | 该途径中的所有SZGR 2.0基因 |
BENPORATH ES WITH H3K27ME3 | 1118 | 744 | 该途径中的所有SZGR 2.0基因 |
Benporath PRC2目标 | 652 | 441 | 该途径中的所有SZGR 2.0基因 |
ASTON MAJOR DEPRESSIVE DISORDER DN | 160 | 110 | 该途径中的所有SZGR 2.0基因 |
Frasor对雌二醇的反应 | 37 | 28 | 该途径中的所有SZGR 2.0基因 |
ZHANG TARGETS OF EWSR1 FLI1 FUSION | 88 | 68 | 该途径中的所有SZGR 2.0基因 |
BROWNE HCMV INFECTION 20HR UP | 240 | 152 | 该途径中的所有SZGR 2.0基因 |
LU AGING BRAIN DN | 153 | 120 | 该途径中的所有SZGR 2.0基因 |
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | 该途径中的所有SZGR 2.0基因 |
CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
CUI TCF21靶向DN | 31 | 23 | 该途径中的所有SZGR 2.0基因 |
KAYO CALORIE RESTRICTION MUSCLE UP | 95 | 64 | 该途径中的所有SZGR 2.0基因 |
麦克道尔急性肺损伤DN | 48 | 33 | 该途径中的所有SZGR 2.0基因 |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | 该途径中的所有SZGR 2.0基因 |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 | 307 | 185 | 该途径中的所有SZGR 2.0基因 |
KONDO PROSTATE CANCER HCP WITH H3K27ME3 | 97 | 72 | 该途径中的所有SZGR 2.0基因 |
HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | 该途径中的所有SZGR 2.0基因 |
LEE METASTASIS AND ALTERNATIVE SPLICING DN | 45 | 31 | 该途径中的所有SZGR 2.0基因 |
MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | 该途径中的所有SZGR 2.0基因 |
MASSARWEH RESPONSE TO ESTRADIOL | 61 | 47 | 该途径中的所有SZGR 2.0基因 |
OUILLETTE CLL 13Q14 DELETION DN | 60 | 38 | 该途径中的所有SZGR 2.0基因 |
riggi ewing肉瘤祖先 | 430 | 288 | 该途径中的所有SZGR 2.0基因 |
SMID BREAST CANCER RELAPSE IN BRAIN DN | 85 | 58 | 该途径中的所有SZGR 2.0基因 |
SMID BREAST CANCER LUMINAL B UP | 172 | 109 | 该途径中的所有SZGR 2.0基因 |
SMID BREAST CANCER BASAL DN | 701 | 446 | 该途径中的所有SZGR 2.0基因 |
TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | 该途径中的所有SZGR 2.0基因 |
ZHENG GLIOBLASTOMA PLASTICITY DN | 58 | 39 | 该途径中的所有SZGR 2.0基因 |
黄达沙替尼抵抗DN | 69 | 44 | 该途径中的所有SZGR 2.0基因 |
YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
甜肺癌Kras DN | 435 | 289 | 该途径中的所有SZGR 2.0基因 |
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE UP | 36 | 24 | 该途径中的所有SZGR 2.0基因 |
ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | 该途径中的所有SZGR 2.0基因 |
POOLA INVASIVE BREAST CANCER DN | 134 | 83 | 该途径中的所有SZGR 2.0基因 |
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | 该途径中的所有SZGR 2.0基因 |
KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | 该途径中的所有SZGR 2.0基因 |
VERHAAK GLIOBLASTOMA PRONEURAL | 177 | 132 | 该途径中的所有SZGR 2.0基因 |
Dutertre雌二醇反应6小时 | 229 | 149 | 该途径中的所有SZGR 2.0基因 |
BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | 该途径中的所有SZGR 2.0基因 |
Fardin缺氧11 | 32 | 29 | 该途径中的所有SZGR 2.0基因 |
ewsr1 fli1融合的骨靶标 | 271 | 165 | 该途径中的所有SZGR 2.0基因 |
Gobert少突胶质细胞分化DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |
RAO BOUND BY SALL4 ISOFORM A | 182 | 108 | 该途径中的所有SZGR 2.0基因 |
GHANDHI BYSTANDER IRRADIATION DN | 12 | 10 | 该途径中的所有SZGR 2.0基因 |
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | 该途径中的所有SZGR 2.0基因 |
第六节。microRNA注释
mirna家族 | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-181 | 4068 | 4074 | M8 | hsa-miR-181abrain | AACAUUCAACGCUGUCGGUGAGU |
hsa-miR-181bSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
hsa-miR-181cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
hsa-miR-181dbrain | aacauucauuguugucggggguggguu | ||||
mir-214 | 2039 | 2045 | M8 | HSA-MIR-214brain | ACAGCAGGCACAGACAGGCAG |
mir-219 | 3175 | 3181 | M8 | HSA-MIR-219brain | ugauuguccaaacgcaauucu |
miR-27 | 4065 | 4071 | 1a | HSA-MIR-27Abrain | UUCACAGUGGCUAAGUUCCGC |
HSA-MIR-27Bbrain | UUCACAGUGGCUAAGUUCUGC | ||||
miR-34/449 | 1187 | 1193 | M8 | hsa-miR-34abrain | UGGCAGUGUCUUAGCUGGUUGUU |
hsa-miR-34c | Aggcaguguaguagcugauugc | ||||
HSA-MIR-449 | uggcaguguauuguagcuggu | ||||
HSA-MIR-449b | AGGCAGUGUAUUGUUAGCUGGC |