Gene Page:MARK3

Summary?
GeneID 4140
Symbol MARK3
Synonyms CTAK1|KP78|PAR1A|Par-1a
Description microtubule affinity regulating kinase 3
Reference MIM:602678|HGNC:HGNC:6897|Ensembl:ENSG00000075413|HPRD:04058|Vega:OTTHUMG00000171789
Gene type protein-coding
Map location 14q32.32
Pascal p-value 8.489E-7
Sherlock p-value 0.463
Fetal beta 0.385
DMG 1 (# studies)
Support Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23090046 14 104094619 MARK3 4.73E-5 -2.428 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ATP6V0C ATP6C | ATP6L | ATPL | VATL | Vma3 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c Two-hybrid BioGRID 16169070
CHGB SCG1 chromogranin B (secretogranin 1) Two-hybrid BioGRID 16169070
DYNLL1 DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1 dynein, light chain, LC8-type 1 - HPRD 14760703
PMPCB Beta-MPP | MPP11 | MPPB | MPPP52 peptidase (mitochondrial processing) beta Two-hybrid BioGRID 16169070
PNPLA2 1110001C14Rik | ATGL | DESNUTRIN | DKFZp667M109 | FP17548 | PEDF-R | TTS-2.2 | TTS2 patatin-like phospholipase domain containing 2 Two-hybrid BioGRID 16169070
RASGRF1 CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 Ras protein-specific guanine nucleotide-releasing factor 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 9543386
SAAL1 FLJ41463 serum amyloid A-like 1 Two-hybrid BioGRID 16169070
SFN YWHAS stratifin Affinity Capture-MS
Two-hybrid		 BioGRID 15778465|16189514
TCEA2 TFIIS transcription elongation factor A (SII), 2 Two-hybrid BioGRID 16169070
TTR HsT2651 | PALB | TBPA transthyretin Two-hybrid BioGRID 16169070
VPS11 END1 | PEP5 | RNF108 | hVPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) Two-hybrid BioGRID 16169070
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Affinity Capture-MS BioGRID 17353931
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Affinity Capture-MS BioGRID 17353931
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 121 84 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 69 40 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
EHRLICH ICF SYNDROM UP 13 8 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 123 76 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 123 86 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 60 42 All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 62 38 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 33 22 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 41 34 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP 93 62 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway