Gene Page:MBL2
Summary?
| GeneID | 4153 |
| Symbol | MBL2 |
| Synonyms | COLEC1 | HSMBPC | MBL | MBL2D | MBP|MBP-C|MBP1|MBPD |
| Description | mannose binding lectin 2 |
| Reference | MIM:154545|HGNC:HGNC:6922|Ensembl:ENSG00000165471|HPRD:01107|Vega:OTTHUMG00000150270 |
| Gene type | protein-coding |
| Map location | 10q11.2 |
| Pascal p-value | 0.744 |
| Fetal beta | 0.06 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | 新闻学会 | Neurotransmitter (GO term level: 4) | 11549596 |
| GO:0005529 | sugar binding | IEA | - | |
| GO:0005537 | mannose binding | NAS | 11549596 | |
| GO:0005488 | binding | IEA | - | |
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0043499 | eukaryotic cell surface binding | TAS | 2477488 | |
| GO:0051635 | bacterial cell surface binding | TAS | 2477488 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0001867 | complement activation, lectin pathway | EXP | 11532276 | |
| GO:0001867 | complement activation, lectin pathway | 新闻学会 | 11549596 | |
| GO:0006979 | response to oxidative stress | NAS | 11549596 | |
| GO:0006958 | complement activation, classical pathway | IEA | - | |
| GO:0006953 | acute-phase response | TAS | 2477488 | |
| GO:0008228 | opsonization | TAS | 2477488 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | EXP | 10639434|10925294 | |
| GO:0005615 | extracellular space | TAS | 1304173 | |
| GO:0005634 | nucleus | IDA | 18029348 | |
| GO:0005730 | nucleolus | IDA | 18029348 | |
| GO:0005737 | cytoplasm | IDA | 18029348 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG COMPLEMENT AND COAGULATION CASCADES | 69 | 49 | All SZGR 2.0 genes in this pathway |
| BIOCARTA COMP PATHWAY | 19 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA LECTIN PATHWAY | 12 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME COMPLEMENT CASCADE | 32 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME CREATION OF C4 AND C2 ACTIVATORS | 10 | 5 | All SZGR 2.0 genes in this pathway |
| REACTOME INITIAL TRIGGERING OF COMPLEMENT | 16 | 10 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 DN | 65 | 39 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| ZHU CMV 24 HR DN | 91 | 64 | All SZGR 2.0 genes in this pathway |
| ZHU CMV ALL DN | 128 | 93 | All SZGR 2.0 genes in this pathway |
| SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
| YANG MUC2 TARGETS DUODENUM 6MO UP | 10 | 5 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP | 174 | 96 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS UP | 266 | 142 | All SZGR 2.0 genes in this pathway |
| NABA ECM附属 | 171 | 89 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |