Gene Page:ME1

Summary?
GeneID 4199
Symbol ME1
Synonyms HUMNDME|MES
Description malic enzyme 1, NADP(+)-dependent, cytosolic
Reference MIM:154250|HGNC:HGNC:6983|Ensembl:ENSG00000065833|HPRD:01102|Vega:OTTHUMG00000015111
Gene type protein-coding
Map location 6q12
Pascal p-value 5.198E-5
eGene Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1341306 chr1 18564668 ME1 4199 0.15 trans
rs4491879 chr3 189373908 ME1 4199 0.17 trans
rs16894557 chr6 28999825 ME1 4199 0.14 trans
rs4789947 chr17 77135790 ME1 4199 0.12 trans
rs1795952 chr17 77136677 ME1 4199 0.12 trans
rs2707040 chr17 77136833 ME1 4199 0.12 trans
rs1503026 chr18 70842605 ME1 4199 0.08 trans
rs12326929 chr18 70864592 ME1 4199 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005488 binding IEA -
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity IDA 8187880
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity ISS -
GO:0009055 electron carrier activity TAS 7622060
GO:0016491 oxidoreductase activity IEA -
GO:0051287 NAD binding TAS 7622060
GO:0030145 manganese ion binding IDA 7622060
GO:0046872 金属离子结合 IEA -
GO:0050661 NADP binding TAS 7622060
GO:0043531 ADP binding TAS 7622060
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006108 malate metabolic process IDA 7622060|8187880
GO:0005975 carbohydrate metabolic process NAS 8187880
GO:0009725 response to hormone stimulus ISS -
GO:0009743 response to carbohydrate stimulus TAS 8187880
GO:0006741 NADP biosynthetic process TAS 8187880
GO:0055114 oxidation reduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol ISS -
GO:0005634 nucleus IDA 18029348
GO:0005730 nucleolus IDA 18029348
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PYRUVATE METABOLISM 40 26 All SZGR 2.0 genes in this pathway
KEGG PPAR SIGNALING PATHWAY 69 47 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 104 72 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 135 82 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 47 34 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 108 84 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 64 38 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 74 45 All SZGR 2.0 genes in this pathway
贝克尔三苯氧胺耐药性DN 52 37 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 64 42 All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 79 58 All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 88 68 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
RORIE TARGETS OF EWSR1 FLI1 FUSION UP 30 22 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8 72 56 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN 50 32 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN 76 57 All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN 84 50 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 5 23 17 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189 112 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 23 14 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 21 12 All SZGR 2.0 genes in this pathway
SINGH NFE2L2 TARGETS 15 12 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 DN 40 22 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 75 48 All SZGR 2.0 genes in this pathway
MOOTHA GLUCONEOGENESIS 32 23 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
ZWANG EGF PERSISTENTLY UP 32 24 All SZGR 2.0 genes in this pathway
HORTON SREBF TARGETS 25 20 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-153 1461 1468 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-30-5p 561 568 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-448 1462 1468 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU