SZGR2 - Beplay体育中心

Summary？

基因	4205
象征	mef2a
Synonyms	ADCAD1\|RSRFC4\|RSRFC9\|mef2
Description	心肌细胞增强子因子2a
Reference	MIM：600660\|HGNC:HGNC:6993\|Ensembl:ENSG00000068305\|HPRD:02807\|Vega：Otthumg00000171937
基因类型	蛋白质编码
Map location	15q26
Pascal p-value	0.156
Sherlock p-value	0.898
胎儿β	-0.883
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	全基因组协会研究	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

EQTL注释

SNP ID	染色体	位置	主持人	Gene Entrez ID	QVALUE	EQTL类型
RS4951059	CHR1	204258018	mef2a	4205	0.18	反式
RS17014160	CHR1	206855799	mef2a	4205	0.1	反式
RS12093398	CHR1	246113979	mef2a	4205	0.04	反式
RS12997903	CHR2	1952083	mef2a	4205	0.11	反式
RS6733654	CHR2	1963270	mef2a	4205	0	反式
rs891877	CHR2	2043348	mef2a	4205	0.13	反式
RS6754787	CHR2	30141949	mef2a	4205	0.01	反式
rs841285	CHR2	129330728	mef2a	4205	0.13	反式
RS7595584	CHR2	175652187	mef2a	4205	8.135E-4	反式
RS10191055	CHR2	201316238	mef2a	4205	0.18	反式
RS1155107	CHR3	26843376	mef2a	4205	0.14	反式
RS1395163	CHR3	31028951	mef2a	4205	0.14	反式
RS6446109	CHR3	60076988	mef2a	4205	0.06	反式
平日339917	CHR3	179669447	mef2a	4205	0.16	反式
rs6848885	CHR4	21582684	mef2a	4205	0.05	反式
snp_a-4196049		0	mef2a	4205	0.01	反式
SNP_A-1853527		0	mef2a	4205	0	反式
RS7677329	CHR4	21586153	mef2a	4205	0.05	反式
RS6813178	CHR4	71575238	mef2a	4205	4.106E-4	反式
rs6834662	CHR4	71605100	mef2a	4205	0.15	反式
RS12639667	CHR4	140243821	mef2a	4205	0.06	反式
RS16870339	CHR5	2705169	mef2a	4205	4.945E-5	反式
RS17146240	CHR5	119522933	mef2a	4205	0.15	反式
rs17146261	CHR5	119534252	mef2a	4205	0.15	反式
RS6930572	CHR6	31428168	mef2a	4205	0.18	反式
rs320082	CHR7	29105404	mef2a	4205	0.03	反式
RS317720	CHR7	29110633	mef2a	4205	0.13	反式
RS317714	CHR7	29115553	mef2a	4205	0.02	反式
RS317724	CHR7	29120565	mef2a	4205	0.13	反式
RS1831517	Chr9	2513405	mef2a	4205	3.203E-4	反式
rs1020772	Chr9	76532511	mef2a	4205	0.07	反式
RS10992675	Chr9	95963315	mef2a	4205	0.06	反式
RS4607971	Chr10	19407890	mef2a	4205	0.01	反式
RS7078127	Chr10	74847633	mef2a	4205	0.14	反式
RS12569493	Chr10	74886042	mef2a	4205	0.14	反式
rs16930362	Chr10	74890320	mef2a	4205	0.04	反式
RS2271904	Chr10	74894374	mef2a	4205	0.14	反式
rs16915029	Chr10	75001994	mef2a	4205	0.03	反式
RS11000607	Chr10	75089777	mef2a	4205	0.19	反式
RS6480700	Chr10	75101689	mef2a	4205	0.16	反式
RS12571454	Chr10	75208954	mef2a	4205	0.05	反式
RS1700369	CHR12	127842232	mef2a	4205	0.13	反式
RS1817693	CHR12	128395998	mef2a	4205	0.19	反式
RS2699067	CHR12	128397197	mef2a	4205	0.19	反式
RS2699066	CHR12	128397415	mef2a	4205	0.19	反式
RS10145685	CHR14	22794892	mef2a	4205	0.03	反式
RS17793827	CHR14	22797560	mef2a	4205	0.01	反式
RS10136383	CHR14	22801078	mef2a	4205	0.01	反式
平日455956	CHR14	43524686	mef2a	4205	0	反式
RS2254834	CHR14	43596184	mef2a	4205	0	反式
RS1954396	CHR14	43601835	mef2a	4205	1.569E-4	反式
RS11158850	CHR14	70757171	mef2a	4205	0	反式
平日239335	CHR16	22897794	mef2a	4205	0.1	反式
RS2369690	CHR16	22920851	mef2a	4205	0.03	反式
RS10500572	CHR16	73559356	mef2a	4205	0.03	反式
rs9965053	CHR18	3166191	mef2a	4205	0.07	反式
RS8087321	CHR18	3168615	mef2a	4205	0.17	反式
RS7239484	CHR18	55443711	mef2a	4205	0.04	反式
RS1761450	CHR19	54818034	mef2a	4205	0.09	反式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ASCL1	ASH1 \| HASH1 \| MASH1 \| bHLHa46	Achaete-Scute复合物同源1（果蝇）	-	HPRD,BioGRID	8662987
EP300	kat3b \|P300	E1A binding protein p300	-	HPRD,BioGRID	12371907
HDAC4	HA6116 \|HD4 \|HDAC-A \|hdaca \|KIAA0288	histone deacetylase 4	-	HPRD,BioGRID	10487761
HDAC5	FLJ90614 \|HD5 \|NY-CO-9	histone deacetylase 5	-	HPRD,BioGRID	10748098
HDAC9	DKFZP779K1053 \|HD7 \|HDAC \|HDAC7 \|HDAC7B \|HDAC9B \|HDAC9FL \|HDRP \|KIAA0744 \|mitr	histone deacetylase 9	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	10487761\|10748098
HDAC9	DKFZP779K1053 \|HD7 \|HDAC \|HDAC7 \|HDAC7B \|HDAC9B \|HDAC9FL \|HDRP \|KIAA0744 \|mitr	histone deacetylase 9	-	HPRD	10825153
MAPK14	CSBP1 \|CSBP2 \|CSPB1 \|Exip \|mxi2 \|PRKM14 \|PRKM15 \|RK \|SAPK2A \|p38 \| p38ALPHA	有丝分裂原激活的蛋白激酶14	-	HPRD,BioGRID	10330143
MAPK7	BMK1 \|ERK4 \|ERK5 \|PRKM7	有丝分裂原激活的蛋白激酶7	-	HPRD,BioGRID	9753748
mef2a	ADCAD1 \|RSRFC4 \|RSRFC9	心肌细胞增强子因子2a	-	HPRD	8575763
MEF2D	DKFZp686I1536	心肌细胞增强子系数2D	-	HPRD,BioGRID	8798771\|9858528
MYOD1	myf3 \|Myod \|PUM \|BHLHC1	myogenic differentiation 1	-	HPRD	8548800 \| 9418854
myog	myf4 \|肌蛋白\|BHLHC3	肌原（肌原因子4）	-	HPRD,BioGRID	1329097
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD家庭成员2	-	HPRD,BioGRID	11160896
SMAD4	DPC4 \|jip \|madh4	SMAD家庭成员4	-	HPRD	11160896
tead1	AA \| REF1 \| TCF13 \| TEF-1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	-	HPRD	12061776
THRA	AR7 \|Ear7 \|ERB-T-1 \|Erba \|erba1 \|MGC000261 \|MGC43240 \|NR1A1 \|thra1 \|thra2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD,BioGRID	12371907
VGLL4	KIAA0121 \| VGL-4	像4（果蝇）这样的残留物	Two-hybrid	Biogrid	15140898

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY	32	25	All SZGR 2.0 genes in this pathway
Biocarta MAPK途径	87	68	All SZGR 2.0 genes in this pathway
Biocarta P38MAPK途径	40	31	All SZGR 2.0 genes in this pathway
Biocarta PGC1A途径	26	20	All SZGR 2.0 genes in this pathway
Biocarta ERK5途径	18	15	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY	38	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出	137	105	All SZGR 2.0 genes in this pathway
Reactome核事件激酶和转录因子激活	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
反应组肌发生	28	20	All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活	50	37	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起	83	63	All SZGR 2.0 genes in this pathway
Reactome先天免疫系统	279	178	All SZGR 2.0 genes in this pathway
Reactome激活的TLR4信号传导	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome收费受体级联	118	84	All SZGR 2.0 genes in this pathway
Gary CD5目标	473	314	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP	95	64	All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名1 DN	126	86	All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名2 DN	77	46	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡	1781	1082	All SZGR 2.0 genes in this pathway
Perez TP53目标	1174	695	All SZGR 2.0 genes in this pathway
Turjanski MAPK7目标	8	8	All SZGR 2.0 genes in this pathway
Turjanski MAPK11目标	5	5	All SZGR 2.0 genes in this pathway
Turjanski MAPK14目标	10	10	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN	483	336	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力	811	508	All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP	35	26	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
NIKOLSKY乳腺癌15 q26扩增子	22	19	All SZGR 2.0 genes in this pathway
Ross AML与CBFB MYH11融合	52	32	All SZGR 2.0 genes in this pathway
马纳洛缺氧	207	145	All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞	293	193	All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN	86	67	All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML	246	180	All SZGR 2.0 genes in this pathway
Hoegerkorp CD44靶向时间DN	25	16	All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn	1237	837	All SZGR 2.0 genes in this pathway
Wang Smarce1靶向DN	371	218	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN	86	66	All SZGR 2.0 genes in this pathway
Delaserna Myod的目标	89	51	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期DN	165	106	All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN	106	68	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
Martinez TP53靶向	602	364	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向	601	369	All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性	578	341	All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP	33	19	All SZGR 2.0 genes in this pathway
米利假足	518	299	All SZGR 2.0 genes in this pathway
CHIARETTI T ALL RELAPSE PROGNOSIS	19	15	All SZGR 2.0 genes in this pathway
黄成人组织茎模块	721	492	All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标	824	528	All SZGR 2.0 genes in this pathway

Gene Page:mef2a