Gene Page:MAP3K1
Summary?
| GeneID | 4214 |
| Symbol | MAP3K1 |
| Synonyms | MAPKKK1|MEKK|MEKK 1|MEKK1|SRXY6 |
| Description | mitogen-activated protein kinase kinase kinase 1 |
| Reference | MIM:600982|HGNC:HGNC:6848|Ensembl:ENSG00000095015|Vega:OTTHUMG00000059486 |
| Gene type | protein-coding |
| Map location | 5 q11.2 |
| Pascal p-value | 0.742 |
| Sherlock p-value | 0.853 |
| Fetal beta | 0.772 |
| DMG | 1(# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 1 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0467 |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MAP3K1 | chr5 | 56171038 | T | C | NM_005921 | . | silent | Schizophrenia | DNM:Fromer_2014 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07791897 | 5 | 55897584 | MAP3K1 | 6.39E-5 | 0.007 | 0.105 | DMG:Montano_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CRB2 | 0.72 | 0.58 |
| COL4A6 | 0.70 | 0.39 |
| LRIG3 | 0.69 | 0.60 |
| NFATC4 | 0.68 | 0.54 |
| COL27A1 | 0.68 | 0.56 |
| DMRTA2 | 0.68 | 0.25 |
| DMRT3 | 0.67 | 0.41 |
| TFAP2C | 0.66 | 0.30 |
| NHLH1 | 0.66 | 0.35 |
| ITGA2 | 0.66 | 0.51 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.18 | -0.08 |
| SYCP3 | -0.17 | -0.18 |
| GNRHR | -0.17 | -0.17 |
| RP9P | -0.17 | -0.27 |
| RALYL | -0.16 | -0.16 |
| GNG8 | -0.16 | -0.20 |
| KCTD9P2 | -0.16 | -0.10 |
| AC073534.1 | -0.16 | -0.12 |
| KLHL1 | -0.16 | -0.07 |
| RTDR1 | -0.16 | -0.13 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0000287 | magnesium ion binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 9808624|11784851|16286467 |16636664 |
|
| GO:0005524 | ATP binding | NAS | - | |
| GO:0004674 | protein serine/threonine kinase activity | IEA | - | |
| GO:0004709 | MAP kinase kinase kinase activity | NAS | 9808624 | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0008270 | 锌离子结合 | IEA | - | |
| GO:0008545 | JUN kinase kinase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006468 | protein amino acid phosphorylation | NAS | 9808624 | |
| GO:0007257 | activation of JNK activity | IEA | - | |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IEA | - | |
| GO:0008637 | apoptotic mitochondrial changes | IEA | - | |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | EXP | 15276183 | |
| GO:0042060 | wound healing | IEA | - | |
| GO:0043010 | camera-type eye development | IEA | - | |
| GO:0030838 | positive regulation of actin filament polymerization | IEA | - | |
| GO:0030334 | regulation of cell migration | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10465784 | |
| GO:0005575 | cellular_component | ND | 9808624 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AXIN1 | AXIN | MGC52315 | axin 1 | Affinity Capture-Western | BioGRID | 10829020|11884395 |
| CD82 | 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 | CD82 molecule | MAP3K1 (MEKK1)与CD82交互(KAI1) promoter. | BIND | 15829968 |
| CDC37 | P50CDC37 | cell division cycle 37 homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 14743216 |
| DVL2 | - | dishevelled, dsh homolog 2 (Drosophila) | Affinity Capture-Western | BioGRID | 10829020 |
| ECSIT | SITPEC | ECSIT homolog (Drosophila) | in vivo | BioGRID | 10465784 |
| FKBP5 | FKBP51 | FKBP54 | MGC111006 | P54 | PPIase | Ptg-10 | FK506 binding protein 5 | Affinity Capture-MS | BioGRID | 14743216 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 9733714 |
| HSP90AA2 | HSP90ALPHA | HSPCA | HSPCAL3 | heat shock protein 90kDa alpha (cytosolic), class A member 2 | Affinity Capture-MS | BioGRID | 14743216 |
| MAP2K1 | MAPKK1 | MEK1 | MKK1 | PRKMK1 | mitogen-activated protein kinase kinase 1 | Affinity Capture-Western | BioGRID | 10969079 |
| MAP2K1 | MAPKK1 | MEK1 | MKK1 | PRKMK1 | mitogen-activated protein kinase kinase 1 | MEKK1 interacts with MEK1. | BIND | 10969079 |
| MAP2K4 | JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 | mitogen-activated protein kinase kinase 4 | MKK4 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK4 and rat MEKK1. | BIND | 15866172 |
| MAP2K4 | JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 | mitogen-activated protein kinase kinase 4 | MEKK1 phosphorylates MEK4. | BIND | 10969079 |
| MAP2K7 | Jnkk2 | MAPKK7 | MKK7 | PRKMK7 | mitogen-activated protein kinase kinase 7 | MEKK1 interacts with MEK7. | BIND | 10969079 |
| MAP2K7 | Jnkk2 | MAPKK7 | MKK7 | PRKMK7 | mitogen-activated protein kinase kinase 7 | MKK7 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK7 and rat MEKK1. | BIND | 15866172 |
| MAP4K2 | BL44 | GCK | RAB8IP | mitogen-activated protein kinase kinase kinase kinase 2 | Reconstituted Complex | BioGRID | 9712898 |
| MAP4K2 | BL44 | GCK | RAB8IP | mitogen-activated protein kinase kinase kinase kinase 2 | GCK interacts with, and phsophorylates, MEKK1. | BIND | 9712898 |
| MAP4K4 | FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIK | mitogen-activated protein kinase kinase kinase kinase 4 | Affinity Capture-Western | BioGRID | 9135144 |
| MAPK1 | ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk | mitogen-activated protein kinase 1 | Affinity Capture-Western | BioGRID | 10969079 |
| MAPK1 | ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk | mitogen-activated protein kinase 1 | MEKK1 interacts with ERK2. | BIND | 10969079 |
| MAPK3 | ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 | mitogen-activated protein kinase 3 | MEKK1 interacts with ERK1. | BIND | 12049732 |
| MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | Affinity Capture-Western Biochemical Activity Reconstituted Complex |
BioGRID | 9405400 |
| MAPK8IP3 | DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2 | mitogen-activated protein kinase 8 interacting protein 3 | Affinity Capture-Western | BioGRID | 10523642 |
| PAK3 | CDKN1A | MRX30 | MRX47 | OPHN3 | PAK3beta | bPAK | hPAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 | in vivo | BioGRID | 9065412 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | MEKK1 interacts with Raf-1. | BIND | 10969079 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10969079 |
| RPL30 | - | ribosomal protein L30 | Affinity Capture-MS | BioGRID | 14743216 |
| RPL4 | - | ribosomal protein L4 | Affinity Capture-MS | BioGRID | 14743216 |
| RPS13 | - | ribosomal protein S13 | Affinity Capture-MS | BioGRID | 14743216 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | Affinity Capture-Western Co-fractionation |
BioGRID | 10346818 |
| UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Reconstituted Complex Two-hybrid |
BioGRID | 9563508 |
| WDR68 | AN11 | HAN11 | WD repeat domain 68 | Affinity Capture-MS | BioGRID | 14743216 |
| YWHAE | 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | Reconstituted Complex | BioGRID | 9452471 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | 71 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG GNRH SIGNALING PATHWAY | 101 | 77 | All SZGR 2.0 genes in this pathway |
| BIOCARTA AT1R PATHWAY | 36 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA BCR PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CD40 PATHWAY | 15 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CERAMIDE PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA EGF PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FAS PATHWAY | 30 | 22 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FCER1 PATHWAY | 41 | 30 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FMLP PATHWAY | 39 | 29 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HIVNEF PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HCMV PATHWAY | 17 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA GLEEVEC PATHWAY | 23 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA KERATINOCYTE PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PYK2 PATHWAY | 31 | 24 | All SZGR 2.0 genes in this pathway |
| BIOCARTA EGFR SMRTE PATHWAY | 11 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA VIP PATHWAY | 29 | 26 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NFKB PATHWAY | 23 | 19 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P38MAPK PATHWAY | 40 | 31 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PDGF PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RAC1 PATHWAY | 23 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAL PATHWAY | 19 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL1R PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCR PATHWAY | 49 | 37 | All SZGR 2.0 genes in this pathway |
| BIOCARTA 41BB PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STRESS PATHWAY | 25 | 18 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TNFR1 PATHWAY | 29 | 21 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TNFR2 PATHWAY | 18 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TOLL PATHWAY | 37 | 31 | All SZGR 2.0 genes in this pathway |
| SA B CELL RECEPTOR COMPLEXES | 24 | 20 | All SZGR 2.0 genes in this pathway |
| ST GA13 PATHWAY | 37 | 32 | All SZGR 2.0 genes in this pathway |
| ST JNK MAPK PATHWAY | 40 | 30 | All SZGR 2.0 genes in this pathway |
| ST FAS SIGNALING PATHWAY | 65 | 54 | All SZGR 2.0 genes in this pathway |
| PID FCER1 PATHWAY | 62 | 43 | All SZGR 2.0 genes in this pathway |
| PID BCR 5PATHWAY | 65 | 50 | All SZGR 2.0 genes in this pathway |
| PID P38 MKK3 6PATHWAY | 26 | 21 | All SZGR 2.0 genes in this pathway |
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
| PID AVB3 OPN PATHWAY | 31 | 29 | All SZGR 2.0 genes in this pathway |
| PID TRAIL PATHWAY | 28 | 20 | All SZGR 2.0 genes in this pathway |
| PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
| PID FAS PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| PID NFAT 3PATHWAY | 54 | 47 | All SZGR 2.0 genes in this pathway |
| PID TNF PATHWAY | 46 | 33 | All SZGR 2.0 genes in this pathway |
| PID CERAMIDE PATHWAY | 48 | 37 | All SZGR 2.0 genes in this pathway |
| PID IFNG PATHWAY | 40 | 34 | All SZGR 2.0 genes in this pathway |
| PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | All SZGR 2.0 genes in this pathway |
| PID TCR JNK PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| PID CASPASE PATHWAY | 52 | 39 | All SZGR 2.0 genes in this pathway |
| PID SMAD2 3PATHWAY | 17 | 13 | All SZGR 2.0 genes in this pathway |
| PID RAC1 PATHWAY | 54 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 21 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 77 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 73 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 83 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TLR4 SIGNALLING | 93 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME TOLL RECEPTOR CASCADES | 118 | 84 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS C UP | 170 | 114 | All SZGR 2.0 genes in this pathway |
| STREICHER LSM1 TARGETS UP | 44 | 34 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 DN | 156 | 106 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS UP | 127 | 79 | All SZGR 2.0 genes in this pathway |
| GARCIA TARGETS OF FLI1 AND DAX1 UP | 57 | 34 | All SZGR 2.0 genes in this pathway |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | 100 | 62 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| BRUNO HEMATOPOIESIS | 66 | 48 | All SZGR 2.0 genes in this pathway |
| WU HBX TARGETS 2 DN | 16 | 11 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
| WU HBX TARGETS 1 DN | 23 | 14 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS DN | 142 | 94 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| ZHENG FOXP3 TARGETS IN THYMUS UP | 196 | 137 | All SZGR 2.0 genes in this pathway |
| OUYANG PROSTATE CANCER PROGRESSION UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS DN | 210 | 128 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| LEE EARLY T LYMPHOCYTE DN | 57 | 36 | All SZGR 2.0 genes in this pathway |
| DANG REGULATED BY MYC DN | 253 | 192 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 | 75 | 48 | All SZGR 2.0 genes in this pathway |
| QI HYPOXIA | 140 | 96 | All SZGR 2.0 genes in this pathway |
| GABRIELY MIR21 TARGETS | 289 | 187 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |