Gene Page:MAP3K3

Summary?
GeneID 4215
Symbol MAP3K3
Synonyms MAPKKK3|MEKK3
Description mitogen-activated protein kinase kinase kinase 3
Reference MIM:602539|HGNC: HGNC: 6855|Ensembl:ENSG00000198909|HPRD:03965|Vega:OTTHUMG00000178905
Gene type protein-coding
Map location 17q23.3
Pascal p-value 0.101
Sherlock p-value 0.301
Fetal beta 1.024
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMedfor genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1421

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 MAP3K3 4215 3.101E-6 trans
rs16955618 chr15 29937543 MAP3K3 4215 1.392E-5 trans
rs7288523 chr22 50082517 MAP3K3 4215 0.16 trans
rs16993189 chrX 144666166 MAP3K3 4215 0.2 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TTYH1 0.81 0.85
MLC1 0.79 0.83
ITGB5 0.77 0.78
BCAN 0.76 0.79
S1PR1 0.75 0.78
RHOJ 0.74 0.69
TNFRSF1A 0.73 0.74
LRP10 0.73 0.79
SLC12A4 0.73 0.75
LAMB2 0.73 0.72
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM49A -0.57 -0.65
DYNC1I1 -0.54 -0.62
NELL2 -0.54 -0.65
GNAI1 -0.53 -0.63
GPR22 -0.53 -0.65
LRRC7 -0.53 -0.61
C1orf96 -0.53 -0.60
HERC3 -0.52 -0.60
ELMOD1 -0.52 -0.57
AGTPBP1 -0.52 -0.61

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005515 protein binding 新闻学会 14743216
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0004709 MAP kinase kinase kinase activity TAS 9006902
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000165 MAPKKK cascade TAS 9006902
GO:0006468 protein amino acid phosphorylation IEA -
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP 12761501
GO:0046777 protein amino acid autophosphorylation IDA 15001576
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043234 protein complex IDA 11256614

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AIFM1 AIF | MGC111425 | PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 - HPRD 14743216
AKAP8L DKFZp434L0650 | HA95 | HAP95 | NAKAP | NAKAP95 A kinase (PRKA) anchor protein 8-like - HPRD 14743216
ATP5A1 ATP5A | ATP5AL2 | ATPM | MOM2 | OMR | ORM | hATP1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle - HPRD 14743216
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset Affinity Capture-Western
Two-hybrid		 BioGRID 15205325
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset BRCA1 interacts with MEKK3. BIND 15205325
C19orf2 FLJ10575 | NNX3 | RMP | URI chromosome 19 open reading frame 2 - HPRD 14743216
CAPZB CAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750 capping protein (actin filament) muscle Z-line, beta - HPRD 14743216
CCT6A CCT-zeta | CCT-zeta-1 | CCT6 | Cctz | HTR3 | MGC126214 | MGC126215 | MoDP-2 | TCP-1-zeta | TCP20 | TCPZ | TTCP20 chaperonin containing TCP1, subunit 6A (zeta 1) - HPRD 14743216
CCT8 C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71 chaperonin containing TCP1, subunit 8 (theta) - HPRD 14743216
CDC37 P50CDC37 cell division cycle 37 homolog (S. cerevisiae) Affinity Capture-MS BioGRID 14743216
DBN1 D0S117E | DKFZp434D064 drebrin 1 - HPRD 14743216
DDB1 DDBA | UV-DDB1 | XAP1 | XPCE | XPE | XPE-BF damage-specific DNA binding protein 1, 127kDa - HPRD 14743216
GAB1 - GRB2-associated binding protein 1 - HPRD,BioGRID 12065326
GNB2 - guanine nucleotide binding protein (G protein), beta polypeptide 2 - HPRD 14743216
HAX1 FLJ17042 | FLJ18492 | FLJ93803 | HCLSBP1 | HS1BP1 | SCN3 HCLS1 associated protein X-1 - HPRD 14743216
HSP90AA2 HSP90ALPHA | HSPCA | HSPCAL3 heat shock protein 90kDa alpha (cytosolic), class A member 2 Affinity Capture-MS BioGRID 14743216
HSPA4 APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RY heat shock 70kDa protein 4 - HPRD,BioGRID 14743216
HSPA8 HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 heat shock 70kDa protein 8 - HPRD 14743216
MAP2K5 HsT17454 | MAPKK5 | MEK5 | PRKMK5 mitogen-activated protein kinase kinase 5 - HPRD,BioGRID 10593883|11073940
MARK2 EMK1 | MGC99619 | PAR-1 | Par1b MAP/microtubule affinity-regulating kinase 2 - HPRD,BioGRID 14743216
MPRIP KIAA0864 | M-RIP | RHOIP3 | p116Rip myosin phosphatase Rho interacting protein - HPRD 14743216
MRCL3 MLCB | MRLC3 myosin regulatory light chain MRCL3 - HPRD 14743216
MYL6 ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM| MLC3NM | MLC3SM myosin, light chain 6, alkali, smooth muscle and non-muscle - HPRD 14743216
NUDC HNUDC | MNUDC | NPD011 nuclear distribution gene C homolog (A. nidulans) - HPRD 14743216
PDRG1 C20orf126 | PDRG p53 and DNA damage regulated 1 - HPRD,BioGRID 14743216
PFDN2 PFD2 prefoldin subunit 2 Affinity Capture-MS BioGRID 14743216
PFDN6 H2-KE2 | HKE2 | KE-2 | MGC70744 | PFD6 prefoldin subunit 6 - HPRD 14743216
PPP1CA MGC15877 | MGC1674 | PP-1A | PPP1A protein phosphatase 1, catalytic subunit, alpha isoform - HPRD 14743216
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform - HPRD 14743216
RIPK1 FLJ39204 | RIP | RIP1 receptor (TNFRSF)-interacting serine-threonine kinase 1 - HPRD,BioGRID 11429546
RNF126 FLJ20552 | MGC1022 | MGC14317 ring finger protein 126 - HPRD 14743216
RPS27L - ribosomal protein S27-like - HPRD 14743216
RUVBL2 CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B RuvB-like 2(大肠杆菌) - HPRD 14743216
SCIN KIAA1905 scinderin - HPRD 14743216
SCRIB CRIB1 | SCRB1 | SCRIB1 | Vartul scribbled homolog (Drosophila) - HPRD 14743216
SEC16A FLJ26737 | KIAA0310 | RP11-413M3.10 | SEC16L | p250 SEC16 homolog A (S. cerevisiae) - HPRD 14743216
SMARCC2 BAF170 | CRACC2 | Rsc8 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 - HPRD 14743216
SPAG9 FLJ13450 | FLJ14006 | FLJ26141 | FLJ34602 | HLC4 | JLP | KIAA0516 | MGC117291 | MGC14967 | MGC74461 | PHET | PIG6 sperm associated antigen 9 - HPRD,BioGRID 12391307
SPTBN1 ELF | SPTB2 | betaSpII spectrin, beta, non-erythrocytic 1 - HPRD 14743216
TIMM50 MGC102733 | TIM50 | TIM50L translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) - HPRD 14743216
TMOD3 UTMOD tropomodulin 3 (ubiquitous) - HPRD 14743216
TRAF7 DKFZp586I021 | MGC7807 | RFWD1 | RNF119 TNF receptor-associated factor 7 TRAF7 interacts with an unspecified isoform of MAP3K3 (MEKK3). BIND 14743216
TRAF7 DKFZp586I021 | MGC7807 | RFWD1 | RNF119 TNF receptor-associated factor 7 Affinity Capture-MS BioGRID 14743216
TUBA3C TUBA2 | bA408E5.3 tubulin, alpha 3c - HPRD 14743216
TUBB2B DKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1 tubulin, beta 2B - HPRD 14743216
TUBB6 HsT1601 | MGC132410 | MGC4083 | TUBB-5 tubulin, beta 6 - HPRD 14743216
UACA FLJ10128 | KIAA1561 | MGC141967 | MGC141969 | NUCLING uveal autoantigen with coiled-coil domains and ankyrin repeats - HPRD 14743216
YWHAE 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide - HPRD,BioGRID 9452471
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Affinity Capture-MS BioGRID 14743216
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide - HPRD 9452471
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 29 20 All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 26 21 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 34 28 All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 46 33 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 58 45 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
TAGHAVI NEOPLASTIC TRANSFORMATION 12 10 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS 36 25 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 115 73 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 1986 1992 1A hsa-let-7a大脑 UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7b大脑 UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7c大脑 UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7d大脑 AGAGGUAGUAGGUUGCAUAGU
hsa-let-7e大脑 UGAGGUAGGAGGUUGUAUAGU
hsa-let-7f大脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98大脑 UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7i大脑 UGAGGUAGUAGUUUGUGCUGU
hsa-let-7a大脑 UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7b大脑 UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7c大脑 UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7d大脑 AGAGGUAGUAGGUUGCAUAGU
hsa-let-7e大脑 UGAGGUAGGAGGUUGUAUAGU
hsa-let-7f大脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98大脑 UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7i大脑 UGAGGUAGUAGUUUGUGCUGU
miR-1/206 2269 2275 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-122 2042 2048 1A hsa-miR-122a UGGAGUGUGACAAUGGUGUUUGU
miR-124.1 589 595 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 589 595 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124大脑 UAAGGCACGCGGUGAAUGCC
miR-133 2115 2121 1A hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-141/200a 391 397 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-145 760 766 m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497 73 79 m8 hsa-miR-15a大脑 UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16大脑 UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15b大脑 UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d 1452 1458 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20a大脑 UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 1461 1468 1A,m8 hsa-miR-181a大脑 AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c大脑 AACAUUCAACCUGUCGGUGAGU
hsa-miR-181d大脑 AACAUUCAUUGUUGUCGGUGGGUU
miR-182 2078 2084 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-188 2514 2520 m8 hsa-miR-188 CAUCCCUUGCAUGGUGGAGGGU
miR-193 2486 2492 m8 hsa-miR-193a AACUGGCCUACAAAGUCCCAG
hsa-miR-193b AACUGGCCCUCAAAGUCCCGCUUU
miR-199 880 886 1A hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-204/211 2513 2519 m8 hsa-miR-204大脑 UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-22 1820 1826 m8 hsa-miR-22大脑 AAGCUGCCAGUUGAAGAACUGU
miR-23 1505 1511 m8 hsa-miR-23a大脑 AUCACAUUGCCAGGGAUUUCC
hsa-miR-23b大脑 AUCACAUUGCCAGGGAUUACC
miR-28 1265 1271 m8 hsa-miR-28大脑 AAGGAGCUCACAGUCUAUUGAG
miR-323 1504 1511 1A,m8 hsa-miR-323大脑 GCACAUUACACGGUCGACCUCU
miR-33 701 707 m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-338 2095 2101 m8 hsa-miR-338大脑 UCCAGCAUCAGUGAUUUUGUUGA
miR-363 2475 2481 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-410 1558 1564 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-496 1500 1506 m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-9 560 567 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-96 2077 2084 1A,m8 hsa-miR-96大脑 UUUGGCACUAGCACAUUUUUGC