Gene Page:最高明的

Summary?
GeneID 4232
Symbol 最高明的
Synonyms PEG1
Description mesoderm specific transcript
Reference MIM:601029|HGNC:HGNC:7028|Ensembl:ENSG00000106484|HPRD:06776|Vega:OTTHUMG00000156661
Gene type protein-coding
Map location 7q32
Pascal p-value 0.96
Sherlock p-value 0.485
Fetal beta 0.788
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM:Ambalavanan_2016 Whole Exome Sequencing This dataset includes 20 de novo mutations detected in 17 COS probands.
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
最高明的 chr7 130139739 C T NM_177524 p.(Pro178Ser) nonsynonymous SNV 0.568 Childhood-onset schizophrenia DNM:Ambalavanan_2016

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04819959 7 130135065 最高明的;MIR335 2.351E-4 0.339 0.037 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs290796 chr7 130415671 最高明的 4232 0.15 cis
rs290795 chr7 130415685 最高明的 4232 0.06 cis
rs1343409 chrX 104143804 最高明的 4232 0.14 trans
rs514013 chrX 150351933 最高明的 4232 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

补充说明:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

补充说明:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AGXT2L1 0.88 0.90
GJB6 0.83 0.86
TAPBPL 0.83 0.84
MYBPC1 0.82 0.83
NQO1 0.82 0.89
AKR1C3 0.81 0.86
NDRG2 0.81 0.90
SDS 0.81 0.87
TMBIM1 0.81 0.85
CRYL1 0.80 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RTF1 -0.60 -0.77
RNF40 -0.58 -0.75
SAFB -0.58 -0.75
PDCD11 -0.57 -0.76
NOL4 -0.57 -0.75
NOVA2 -0.57 -0.74
PHF14 -0.57 -0.78
UBTF -0.57 -0.75
GTF2F1 -0.56 -0.73
POLR3A -0.56 -0.70

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC LEUKEMIA UP 368 234 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 68 41 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID UP 45 26 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE DN 35 20 All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD UP 28 19 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN 41 33 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184 114 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
SCHUHMACHER MYC TARGETS UP 80 57 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 6HR 59 38 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
韦斯顿VEGFA目标12小时 35 23 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
克莱顿ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP 73 53 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN 88 42 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 108 68 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 142 79 All SZGR 2.0 genes in this pathway
LEE INTRATHYMIC T PROGENITOR 21 14 All SZGR 2.0 genes in this pathway
VALK AML WITH CEBPA 37 27 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP 166 105 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 79 47 All SZGR 2.0 genes in this pathway
国外RB1增长目标 243 155 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION TOP20 UP 20 14 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 63 47 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway