Gene Page:MAP3K10

年代ummary?
GeneID 4294
年代ymbol MAP3K10
年代ynonyms MEKK10|MLK2|MST
Description mitogen-activated protein kinase kinase kinase 10
Reference MIM:600137|HGNC:HGNC:6849|Ensembl:ENSG00000130758|HPRD:02533|Vega:OTTHUMG00000182591
Gene type protein-coding
Map location 19q13.2
Pascal p-value 0.484
年代herlock p-value 0.659
Fetal beta -0.627
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

年代ection I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) 年代tudy
cg20005624 19 40697059 MAP3K10 1.36E-9 -0.015 1.37E-6 DMG:Jaffe_2016


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
AP000349.1 0.99 0.90
GPC2 0.89 0.84
年代BK1 0.89 0.82
ACTG1 0.88 0.79
C6orf134 0.88 0.84
MYD88 0.87 0.82
年代RC 0.87 0.80
TMEM44 0.87 0.80
LRRC61 0.87 0.83
IGLON5 0.87 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
C5orf53 -0.63 -0.74
HLA-F -0.62 -0.71
ALDOC -0.61 -0.68
CLU -0.61 -0.68
AIFM3 -0.61 -0.68
FBXO2 -0.61 -0.65
PTH1R -0.60 -0.64
LDHD -0.60 -0.65
RGN -0.59 -0.68
AP003117.1 -0.59 -0.66

年代ection IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental 年代ource PubMed ID
CDC42 CDC42Hs | G25K cell division cycle 42 (GTP binding protein, 25kDa) - HPRD,BioGRID 9427749
CLTC CHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034 clathrin, heavy chain (Hc) - HPRD,BioGRID 12105200
CNKSR1 CNK | CNK1 | KSR connector enhancer of kinase suppressor of Ras 1 CNKSR1 (hCNK1) interacts with MAP3K10 (MLK2). This interaction was modelled on a demonstrated interaction between human CNKSR1 and MAP3K10 from an unspecified species. BIND 15753034
DLG4 FLJ97752 | FLJ98574 | PSD95 | SAP90 discs, large homolog 4 (Drosophila) - HPRD,BioGRID 11152698
DNM1 DNM dynamin 1 Reconstituted Complex BioGRID 9742220
DNM1L DLP1 | DRP1 | DVLP | DYMPLE | DYNIV-11 | FLJ41912 | HDYNIV | VPS1 dynamin 1-like - HPRD 9742220
HPCA BDR2 hippocalcin Affinity Capture-Western BioGRID 9427749
HTT 高清| IT15 huntingtin MLK2 SH3 domain interacts with Huntingtin BIND 10801775
HTT 高清| IT15 huntingtin - HPRD,BioGRID 10801775
KIF17 KIAA1405 | KIF17B | KIF3X kinesin family member 17 Two-hybrid BioGRID 9427749
KIF3A - kinesin family member 3A - HPRD,BioGRID 9427749
KIF3B HH0048 | KIAA0359 kinesin family member 3B - HPRD 9427749
KIFAP3 FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1 kinesin-associated蛋白3 - HPRD,BioGRID 9427749
KRTAP3P1 KAP3A keratin associated protein 3 pseudogene 1 Affinity Capture-Western BioGRID 9427749
MAP2K4 JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 mitogen-activated protein kinase kinase 4 - HPRD,BioGRID 9182538
MAPK8IP1 IB1 | JIP-1 | JIP1 | PRKM8IP mitogen-activated protein kinase 8 interacting protein 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10490659
MAPK8IP2 IB2 | JIP2 | PRKM8IPL mitogen-activated protein kinase 8 interacting protein 2 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10490659
NEUROD1 BETA2 | BHF-1 | NEUROD | bHLHa3 neurogenic differentiation 1 Affinity Capture-Western
Biochemical Activity
Two-hybrid		 BioGRID 12881483
PHB PHB1 prohibitin - HPRD 9629920
RAC1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Reconstituted Complex BioGRID 9427749
RACGAP1 HsCYK-4 | ID-GAP | MgcRacGAP Rac GTPase activating protein 1 - HPRD 9427749
年代H3RF1 FLJ21602 | KIAA1494 | POSH | RNF142 | SH3MD2 年代H3 domain containing ring finger 1 - HPRD 14504284
TUBB2A TUBB | TUBB2 | dJ40E16.7 tubulin, beta 2A - HPRD 9629920
YWHAE 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide - HPRD,BioGRID 9427749


年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
年代T P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
年代T JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 26 21 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 74 48 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 71 45 All SZGR 2.0 genes in this pathway
KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION 35 22 All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP 17 12 All SZGR 2.0 genes in this pathway