Gene Page:MAP3K11
Summary?
| GeneID | 4296 |
| Symbol | MAP3K11 |
| Synonyms | MEKK11|MLK-3|MLK3|PTK1|SPRK |
| Description | mitogen-activated protein kinase kinase kinase 11 |
| Reference | MIM:600050|HGNC:HGNC:6850|Ensembl:ENSG00000173327|HPRD:02502|Vega:OTTHUMG00000166529 |
| Gene type | protein-coding |
| Map location | 11q13.1-q13.3 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.262 |
| Fetal beta | -0.499 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg21651436 | 11 | 65381610 | MAP3K11 | -0.023 | 0.96 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7830259 | chr8 | 14087643 | MAP3K11 | 4296 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AKT1 | AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 | - | HPRD,BioGRID | 12458207 |
| CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD,BioGRID | 10799501 |
| CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | - | HPRD,BioGRID | 10713178 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | discs, large homolog 4 (Drosophila) | Affinity Capture-Western | BioGRID | 11152698 |
| IKBKB | FLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | - | HPRD,BioGRID | 10713178 |
| KIF17 | KIAA1405 | KIF17B | KIF3X | kinesin family member 17 | Two-hybrid | BioGRID | 9427749 |
| KIF3A | - | kinesin family member 3A | - | HPRD,BioGRID | 9427749 |
| KIF3B | HH0048 | KIAA0359 | kinesin family member 3B | Two-hybrid | BioGRID | 9427749 |
| KIFAP3 | FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1 | kinesin-associated蛋白3 | Two-hybrid | BioGRID | 9427749 |
| MAP2K1 | MAPKK1 | MEK1 | MKK1 | PRKMK1 | mitogen-activated protein kinase kinase 1 | MEK1 interacts with MLK3. | BIND | 15258589 |
| MAP2K4 | JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 | mitogen-activated protein kinase kinase 4 | Biochemical Activity | BioGRID | 10187804 |
| MAP2K7 | Jnkk2 | MAPKK7 | MKK7 | PRKMK7 | mitogen-activated protein kinase kinase 7 | MAP3K11 (MLK3) phosphorylates MAP2K7 (MKK7). This interaction was modeled on a demonstrated interaction between human MAP3K11 and MAP2K7 from an unspecified species. | BIND | 15001580 |
| MAP2K7 | Jnkk2 | MAPKK7 | MKK7 | PRKMK7 | mitogen-activated protein kinase kinase 7 | - | HPRD,BioGRID | 10187804 |
| MAP3K11 | MGC17114 | MLK-3 | MLK3 | PTK1 | SPRK | mitogen-activated protein kinase kinase kinase 11 | - | HPRD | 11590155 |
| MAP3K12 | DLK | MUK | ZPK | ZPKP1 | mitogen-activated protein kinase kinase kinase 12 | - | HPRD | 10187804 |
| MAP4K1 | HPK1 | mitogen-activated protein kinase kinase kinase kinase 1 | - | HPRD,BioGRID | 11053428 |
| MAPK8IP1 | IB1 | JIP-1 | JIP1 | PRKM8IP | mitogen-activated protein kinase 8 interacting protein 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10490659 |
| MAPK8IP2 | IB2 | JIP2 | PRKM8IPL | mitogen-activated protein kinase 8 interacting protein 2 | - | HPRD,BioGRID | 10490659 |
| MAPK8IP3 | DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2 | mitogen-activated protein kinase 8 interacting protein 3 | - | HPRD,BioGRID | 10629060 |
| RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | - | HPRD | 9427749 |
| RHOG | ARHG | MGC125835 | MGC125836 | ras同族体基因家族,成员G(ρG) | - | HPRD,BioGRID | 12376551 |
| SH3RF1 | FLJ21602 | KIAA1494 | POSH | RNF142 | SH3MD2 | SH3域帐目ining ring finger 1 | - | HPRD,BioGRID | 14504284 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | 所有SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | 所有SZGR 2.0 genes in this pathway |
| ST INTEGRIN SIGNALING PATHWAY | 82 | 62 | 所有SZGR 2.0 genes in this pathway |
| ST JNK MAPK PATHWAY | 40 | 30 | 所有SZGR 2.0 genes in this pathway |
| PID REELIN PATHWAY | 29 | 29 | 所有SZGR 2.0 genes in this pathway |
| PID CDC42 PATHWAY | 70 | 51 | 所有SZGR 2.0 genes in this pathway |
| PID IFNG PATHWAY | 40 | 34 | 所有SZGR 2.0 genes in this pathway |
| PID RAC1 PATHWAY | 54 | 37 | 所有SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE UP | 134 | 93 | 所有SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 UP | 209 | 139 | 所有SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA HIF1A UP | 77 | 49 | 所有SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 AND HIF1A DN | 103 | 71 | 所有SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | 所有SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | 所有SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | 所有SZGR 2.0 genes in this pathway |
| AMIT SERUM RESPONSE 240 MCF10A | 57 | 36 | 所有SZGR 2.0 genes in this pathway |
| LIN APC TARGETS | 77 | 55 | 所有SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | 所有SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | 所有SZGR 2.0 genes in this pathway |
| KAAB FAILED HEART ATRIUM UP | 38 | 30 | 所有SZGR 2.0 genes in this pathway |
| ZHANG PROLIFERATING VS QUIESCENT | 51 | 41 | 所有SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | 所有SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | 所有SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | 所有SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 所有SZGR 2.0 genes in this pathway |
| LIU IL13 MEMORY MODEL UP | 17 | 12 | 所有SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE VIA P38 COMPLETE | 227 | 151 | 所有SZGR 2.0 genes in this pathway |