Gene Page:MLLT1

Summary?
GeneID 4298
Symbol MLLT1
Synonyms ENL|LTG19|YEATS1
Description myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Reference MIM:159556|HGNC:HGNC:7134|Ensembl:ENSG00000130382|HPRD:15933|Vega:OTTHUMG00000180757
Gene type protein-coding
Map location 19p13.3
Pascal p-value 0.049
Fetal beta 0.24
DMG 1 (# studies)
eGene Cerebellum
Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25825726 19 6230459 MLLT1 3.68E-5 0.241 0.02 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1146358 chr1 116657767 MLLT1 4298 4.167E-4 trans
rs16854815 chr1 204931605 MLLT1 4298 0.09 trans
rs1934578 chr1 246016476 MLLT1 4298 0.02 trans
rs1934577 chr1 246016542 MLLT1 4298 0 trans
rs17012898 chr2 33601648 MLLT1 4298 0.19 trans
rs17012916 chr2 33606031 MLLT1 4298 0.12 trans
rs2716734 chr2 39947720 MLLT1 4298 1.093E-4 trans
rs2716736 chr2 39947946 MLLT1 4298 1.093E-4 trans
rs6754175 chr2 135333296 MLLT1 4298 0.01 trans
rs17039866 chr3 4136543 MLLT1 4298 0.13 trans
rs11928084 chr3 4138812 MLLT1 4298 0.04 trans
rs16850133 chr3 140030776 MLLT1 4298 1.966E-5 trans
rs7638929 chr3 140031075 MLLT1 4298 0 trans
rs2713946 chr4 111197804 MLLT1 4298 0.08 trans
rs16869878 chr5 2523760 MLLT1 4298 0.02 trans
rs467856 chr5 3128168 MLLT1 4298 0 trans
rs16902549 chr5 13407346 MLLT1 4298 0.04 trans
rs1010527 chr5 13508264 MLLT1 4298 0.15 trans
rs1992711 chr5 13510917 MLLT1 4298 0.15 trans
rs16888245 chr5 19737051 MLLT1 4298 0.18 trans
rs6451640 chr5 20088127 MLLT1 4298 0.03 trans
snp_a-2169623 0 MLLT1 4298 3.33E-5 trans
rs6873234 chr5 169299967 MLLT1 4298 0.01 trans
rs7383548 0 MLLT1 4298 0.01 trans
rs2016128 chr6 42442743 MLLT1 4298 0.08 trans
rs1587434 chr6 66615354 MLLT1 4298 6.025E-10 trans
rs7746331 chr6 84197931 MLLT1 4298 0.19 trans
rs4557559 chr6 118406801 MLLT1 4298 0.02 trans
rs4725268 chr7 10334857 MLLT1 4298 0.19 trans
rs17154235 chr7 26692981 MLLT1 4298 0.16 trans
rs4947631 chr7 50603378 MLLT1 4298 0 trans
rs10257132 chr7 51422943 MLLT1 4298 0.01 trans
rs529539 chr7 84003500 MLLT1 4298 0.03 trans
rs10100949 chr8 23865007 MLLT1 4298 0.2 trans
rs17051420 chr8 23872203 MLLT1 4298 0.13 trans
snp_a-2064115 0 MLLT1 4298 0.13 trans
rs17051430 chr8 23874554 MLLT1 4298 0.13 trans
rs7815377 chr8 23874876 MLLT1 4298 0.15 trans
rs10503771 chr8 25304019 MLLT1 4298 0.07 trans
rs2810511 chr9 136791540 MLLT1 4298 0.03 trans
rs10994470 chr10 51558659 MLLT1 4298 0.04 trans
rs16928875 chr10 73212531 MLLT1 4298 0.12 trans
rs17106311 chr10 87897271 MLLT1 4298 0.14 trans
rs17107175 chr10 88646323 MLLT1 4298 0.04 trans
rs1539587 chr10 115372155 MLLT1 4298 0.08 trans
rs7129903 chr11 7775320 MLLT1 4298 0.09 trans
rs4944475 chr11 83985410 MLLT1 4298 0.04 trans
rs12270706 chr11 109947508 MLLT1 4298 0.15 trans
rs11183748 chr12 47516125 MLLT1 4298 0.18 trans
rs12423193 chr12 63753383 MLLT1 4298 0.01 trans
rs9888446 chr12 63785677 MLLT1 4298 0 trans
rs1400878 chr12 83609397 MLLT1 4298 0 trans
rs16945217 chr12 115679171 MLLT1 4298 0 trans
rs998923 chr13 35507810 MLLT1 4298 3.034E-4 trans
rs9590075 chr13 95414389 MLLT1 4298 0.13 trans
snp_a-2222355 0 MLLT1 4298 0 trans
rs2253509 chr15 28144975 MLLT1 4298 0.12 trans
rs7176277 chr15 63316182 MLLT1 4298 0.18 trans
rs6495316 chr15 78986100 MLLT1 4298 0.06 trans
rs1461211 chr15 88628773 MLLT1 4298 0.06 trans
rs2027819 chr16 19331736 MLLT1 4298 0.13 trans
rs12596294 chr16 72587092 MLLT1 4298 0.16 trans
rs1015663 chr17 14238086 MLLT1 4298 0.07 trans
rs295104 chr17 32814665 MLLT1 4298 0.01 trans
rs349973 chr17 50642288 MLLT1 4298 0.18 trans
rs8078127 chr17 50761342 MLLT1 4298 0.01 trans
rs10512600 chr17 72812978 MLLT1 4298 6.264E-4 trans
rs2661679 chr17 76172103 MLLT1 4298 0 trans
rs7217417 chr17 76173174 MLLT1 4298 0 trans
rs6040607 chr20 11371092 MLLT1 4298 0.04 trans
rs4270401 chr20 61343887 MLLT1 4298 0.01 trans
rs225434 chr21 43724740 MLLT1 4298 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SPSB4 0.85 0.83
CD276 0.85 0.88
EPHB2 0.84 0.81
PATZ1 0.84 0.84
CTNND1 0.83 0.80
F2R 0.83 0.81
CCNF 0.83 0.79
IPO4 0.83 0.83
MAPK7 0.83 0.87
U2AF2 0.82 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.64 -0.77
HLA-F -0.60 -0.66
CA4 -0.58 -0.68
AF347015.27 -0.58 -0.74
SLC16A11 -0.58 -0.59
CA11 -0.58 -0.71
AF347015.31 -0.58 -0.74
SPARCL1 -0.58 -0.63
AF347015.33 -0.57 -0.73
FXYD1 -0.56 -0.71

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NADERI BREAST CANCER PROGNOSIS UP 50 26 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER UP 38 26 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 68 45 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 66 38 All SZGR 2.0 genes in this pathway