Summary
基因 4318
象征 MMP9
Synonyms clg4b | gelb | mandp2 | mmp-9
Description 基质金属肽酶9
Reference MIM:120361|HGNC:HGNC:7176|Ensembl:ENSG00000100985|HPRD:00387|Vega:OTTHUMG00000033044
基因类型 蛋白质编码
Map location 20q13.12
Pascal p-value 0.093
胎儿β -0.436
主持人

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
PMID:cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在:精神分裂症,精神分裂症,精神分裂症 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达(GTEX)

无法使用

Devlopment期间的基因表达(BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
AREG ar |crdgf |MGC13647 |SDGF 两次凝聚蛋白 - HPRD 10389762
BTC - betacellulin - HPRD 10706134
CD44 CDW44 |CSPG8 |ECMR-III |hcell |在|lhr |MC56 |mdu2 |mdu3 |MGC10468 | MIC4 | MUTCH-I | Pgp1 CD44分子(印度血型) - HPRD 10652271
Col1a1 OI4 collagen, type I, alpha 1 - HPRD,BioGRID 9878537
Col1a2 OI4 collagen, type I, alpha 2 - HPRD,BioGRID 9878537
COL4A1 逮捕 collagen, type IV, alpha 1 - HPRD,BioGRID 9878537
COL4A2 DKFZp686I14213 | FLJ22259 collagen, type IV, alpha 2 - HPRD,BioGRID 9878537
COL4A3 - collagen, type IV, alpha 3 (Goodpasture antigen) - HPRD,BioGRID 9878537
COL4A4 CA44 collagen, type IV, alpha 4 - HPRD,BioGRID 9878537
COL4A5 ASLN | ATS | CA54 | MGC167109 | MGC42377 collagen, type IV, alpha 5 - HPRD,BioGRID 9878537
COL4A6 MGC88184 collagen, type IV, alpha 6 - HPRD,BioGRID 9878537
CXCL5 ENA-78 |Scyb5 chemokine (C-X-C motif) ligand 5 - HPRD,BioGRID 12950257
CXCL6 CKA-3 |GCP-2 |GCP2 |Scyb6 趋化因子(C-X-C基序)配体6(粒细胞趋化蛋白2) 生化活动 Biogrid 12950257
FN1 CIG |DKFZP686F10164 |DKFZP686H0342 |DKFZP686I1370 |DKFZP686O13149 |ed-b |Finc |fn |fnz |gfnd | GFND2 | LETS | MSF 纤连蛋白1 - HPRD 11134254
LCN2 NGAL lipocalin 2 - HPRD,BioGRID 1281792|10339412
MMP7 MMP-7 |mpsl1 |泵-1 matrix metallopeptidase 7 (matrilysin, uterine) - HPRD,BioGRID 7896811
MMP9 CLG4B | GELB | MMP-9 基质金属肽酶9(明胶酶B,92KDA明胶酶,92KDA IV型胶原酶) - HPRD 12051944
PZP CPAMD6 |MGC133093 怀孕区蛋白 - HPRD 9344465
RUCK ST15 |Hreck 带有卡扎尔图案的富含循环的蛋白质诱导蛋白 - HPRD 9789069
TGFB1 CED |DPD1 |TGFB |TGFBETA transforming growth factor, beta 1 生化活动 Biogrid 10652271
THBS1 THBS | TSP | TSP1 thrombospondin 1 - HPRD,BioGRID 10900205
THBS2 TSP2 thrombospondin 2 - HPRD,BioGRID 10900205
timp3 HSMRK222 | K222 | K222TA2 | SFD TIMP金属肽酶抑制剂3 - HPRD,BioGRID 11827795


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg白细胞跨内皮迁移 118 78 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
Kegg膀胱癌 42 33 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID ER非原始组途径 41 35 All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY 31 29 All SZGR 2.0 genes in this pathway
PID FRA路径 37 28 All SZGR 2.0 genes in this pathway
PID MYC活动途径 79 62 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID AMB2中性粒细胞途径 41 32 All SZGR 2.0 genes in this pathway
PID Syndecan 4途径 32 25 All SZGR 2.0 genes in this pathway
PID AP1途径 70 60 All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 42 30 All SZGR 2.0 genes in this pathway
PID Syndecan 1途径 46 29 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID FGF途径 55 37 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
细胞外基质的反应组降解 29 11 All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 87 42 All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤 205 140 All SZGR 2.0 genes in this pathway
LU TUMOR VASCULATURE UP 29 17 All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病 368 234 All SZGR 2.0 genes in this pathway
gal白血病干细胞DN 244 153 All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合8D DN的Takeda目标 205 127 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 16d DN的Takeda目标 143 83 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
Senese HDAC2靶向 114 66 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
hahtola sezary综合征 98 58 All SZGR 2.0 genes in this pathway
HAHTOLA蕈样了 19 15 All SZGR 2.0 genes in this pathway
王食道癌与正常 121 72 All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 DN 16 10 All SZGR 2.0 genes in this pathway
Ozanne AP1靶向 18 11 All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS 10 9 All SZGR 2.0 genes in this pathway
贝克造血STAT3目标 16 12 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 88 58 All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 95 58 All SZGR 2.0 genes in this pathway
Agarwal AKT途径目标 10 9 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌 358 245 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
Onder CDH1目标2 DN 464 276 All SZGR 2.0 genes in this pathway
Shepard粉碎和燃烧突变体 197 110 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast向上 398 262 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 87 58 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 121 65 All SZGR 2.0 genes in this pathway
黑川肝癌化学疗法 12 8 All SZGR 2.0 genes in this pathway
YE METASTATIC LIVER CANCER 27 13 All SZGR 2.0 genes in this pathway
HOXA9和MEIS1 DN的HESS目标 77 48 All SZGR 2.0 genes in this pathway
Lenaour树突状细胞成熟DN 128 90 All SZGR 2.0 genes in this pathway
康(Kang)由tert dn永生 102 67 All SZGR 2.0 genes in this pathway
叶中性粒细胞颗粒成分 25 13 All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML 246 180 All SZGR 2.0 genes in this pathway
MLL AF9融合的Kumar目标 405 264 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
Sesto对UV C6的反应 39 27 All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN 245 144 All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN 106 68 All SZGR 2.0 genes in this pathway
URS脂肪细胞分化DN 30 20 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
斯坦因·埃斯拉(Stein Esrra)瞄准 388 234 All SZGR 2.0 genes in this pathway
海勒被甲基化沉默 282 183 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
Mishra癌相关的成纤维细胞 24 14 All SZGR 2.0 genes in this pathway
威尔逊蛋白酶在肿瘤骨接口上 21 14 All SZGR 2.0 genes in this pathway
WILENSKY RESPONSE TO DARAPLADIB 29 20 All SZGR 2.0 genes in this pathway
lu肿瘤内皮标记 22 14 All SZGR 2.0 genes in this pathway
lu肿瘤血管生成 25 22 All SZGR 2.0 genes in this pathway
Cromer肿瘤发生 63 36 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记 165 118 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN 252 155 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
Rutella对CSF2RB和IL4的响应 338 225 All SZGR 2.0 genes in this pathway
Rutella对HGF的反应 418 282 All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4的反应 408 276 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向角质形成细胞 91 63 All SZGR 2.0 genes in this pathway
池子侵入性乳腺癌 288 168 All SZGR 2.0 genes in this pathway
清肝癌子类CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
清肝癌亚类增殖 178 108 All SZGR 2.0 genes in this pathway
Mikkelsen MCV6 HCP带有H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
Schoen NFKB信号 34 26 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 All SZGR 2.0 genes in this pathway
Hahtola CTCL皮肤 26 19 All SZGR 2.0 genes in this pathway
HAHTOLA CTCL发病机理 16 9 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER POOR PROGNOSIS 55 30 All SZGR 2.0 genes in this pathway
Mikkelsen MEF HCP带有H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
Noushmehr GBM被甲基化沉默 50 32 All SZGR 2.0 genes in this pathway
由PML Rara Fusion绑定的Martens 456 287 All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老 572 352 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
康AR目标 17 10 All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标 824 528 All SZGR 2.0 genes in this pathway
CTBP1的PURBEY目标不是SATB1 344 215 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时 199 143 All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38 337 236 All SZGR 2.0 genes in this pathway
Roessler肝癌转移 107 72 All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 95 54 All SZGR 2.0 genes in this pathway
NABA ECM监管机构 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway