Gene Page:ASGR1
Summary?
| GeneID | 432 |
| Symbol | ASGR1 |
| Synonyms | ASGPR|ASGPR1|CLEC4H1|HL-1 |
| Description | asialoglycoprotein receptor 1 |
| Reference | MIM:108360|HGNC:HGNC:742|Ensembl:ENSG00000141505|HPRD:00151|Vega:OTTHUMG00000102159 |
| Gene type | protein-coding |
| Map location | 17p13.2 |
| Pascal p-value | 6.873E-4 |
| Sherlock p-value | 0.74 |
| eGene | Myers' cis & trans 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6048101 | chr20 | 22429986 | ASGR1 | 432 | 0.07 | trans | ||
| rs4632416 | chr20 | 22437090 | ASGR1 | 432 | 0.06 | trans | ||
| rs4459793 | chr20 | 22439811 | ASGR1 | 432 | 0.08 | trans | ||
| rs6048112 | chr20 | 22442814 | ASGR1 | 432 | 0.18 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| POP4 | 0.79 | 0.75 |
| PYCRL | 0.78 | 0.76 |
| TRUB2 | 0.78 | 0.74 |
| PHKG2 | 0.78 | 0.75 |
| SNX17 | 0.78 | 0.79 |
| MED29 | 0.78 | 0.79 |
| DRG2 | 0.78 | 0.77 |
| FLOT1 | 0.77 | 0.75 |
| UQCRC1 | 0.77 | 0.76 |
| FOXRED1 | 0.77 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.49 | -0.33 |
| AF347015.2 | -0.46 | -0.25 |
| MT-ATP8 | -0.45 | -0.31 |
| AC010300.1 | -0.45 | -0.42 |
| AF347015.8 | -0.44 | -0.29 |
| MT-CYB | -0.44 | -0.29 |
| AF347015.26 | -0.44 | -0.27 |
| AF347015.15 | -0.44 | -0.28 |
| AF347015.21 | -0.41 | -0.27 |
| MT-CO2 | -0.40 | -0.26 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA神经母细胞瘤拷贝数 | 181 | 108 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC UP | 202 | 115 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| FONTAINE FOLLICULAR THYROID ADENOMA UP | 75 | 43 | All SZGR 2.0 genes in this pathway |
| FONTAINE PAPILLARY THYROID CARCINOMA DN | 80 | 53 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |
| WARTERS RESPONSE TO IR SKIN | 83 | 44 | All SZGR 2.0 genes in this pathway |