Gene Page:MMP17

Summary?
GeneID 4326
Symbol MMP17
Synonyms MMP-17|MT4-MMP|MT4MMP|MTMMP4
Description matrix metallopeptidase 17
Reference MIM:602285|HGNC:HGNC:7163|Ensembl:ENSG00000198598|HPRD:03793|Vega:OTTHUMG00000168050
Gene type protein-coding
Map location 12q24.3
Pascal p-value 0.415
Sherlock p-value 0.942
Fetal beta -0.447
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10632507 12 132317390 MMP17 1.951E-4 0.434 0.035 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6588375 chr1 50594945 MMP17 4326 0.11 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
LTK 0.85 0.76
KIAA0748 0.77 0.75
FHL2 0.77 0.60
AC103681.1 0.75 0.69
HTR3B 0.75 0.70
SLC22A9 0.75 0.70
ITPKA 0.74 0.71
GALNTL5 0.74 0.68
SLC25A45 0.74 0.73
EXTL1 0.74 0.72
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PKN1 -0.44 -0.49
PDE9A -0.43 -0.52
TUBB2B -0.42 -0.53
YBX1 -0.42 -0.53
FAM36A -0.42 -0.48
KIAA1949 -0.41 -0.45
IDH1 -0.41 -0.48
NKIRAS2 -0.40 -0.34
GPR125 -0.40 -0.38
ARMCX6 -0.40 -0.44

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 29 11 All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 87 42 All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 UP 11 9 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 12Q24 AMPLICON 15 7 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185 114 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 39 26 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4 13 10 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR UP 17 10 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway