Gene Page:MPZ

Summary?
GeneID 4359
Symbol MPZ
Synonyms CHM|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|CMTDID|DSS|HMSNIB|MPP|P0
Description myelin protein zero
Reference MIM:159440|HGNC:HGNC:7225|Ensembl:ENSG00000158887|HPRD:01159|Vega:OTTHUMG00000034341
Gene type protein-coding
Map location 1q23.3
Fetal beta -0.321

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
GO:0005198 structural molecule activity NAS 7693129
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008366 axon ensheathment NAS neuron, axon (GO term level: 12) -
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 7693129
GO:0007638 mechanosensory行为 IEA -
GO:0045217 cell-cell junction maintenance IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -
GO:0016020 membrane IEA -
GO:0005886 plasma membrane NAS 7693130
GO:0005887 integral to plasma membrane TAS 7506095

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 108 84 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 321 327 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-149 790 796 m8 hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-203.1 1130 1136 m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-223 1126 1132 1A hsa-miR-223 UGUCAGUUUGUCAAAUACCCC
miR-485-5p 141 148 1A,m8 hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC