Gene Page:KLK12
Summary?
GeneID | 43849 |
Symbol | KLK12 |
Synonyms | KLK-L5|KLKL5 |
Description | kallikrein related peptidase 12 |
Reference | MIM:605539|HGNC:HGNC:6360|Ensembl:ENSG00000186474|HPRD:05705|Vega:OTTHUMG00000165806 |
Gene type | protein-coding |
Map location | 19q13.33 |
Pascal p-value | 0.621 |
Fetal beta | -0.442 |
DMG | 1 (# studies) |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
去_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg24815853 | 19 | 51538416 | KLK12 | 2.97E-6 | -0.391 | 0.009 | DMG:Wockner_2014 |
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs17714461 | chr19 | 51425105 | KLK12 | 43849 | 0.14 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/KLK12_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | 去term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
去:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
去:0004252 | serine-type endopeptidase activity | NAS | glutamate (GO term level: 7) | 11054574 |
去:0003824 | catalytic activity | IEA | - | |
去:0008233 | peptidase activity | IEA | - | |
Biological process | 去term | Evidence | Neuro keywords | PubMed ID |
去:0006508 | proteolysis | IEA | - | |
去:0006508 | proteolysis | NAS | - | |
Cellular component | 去term | Evidence | Neuro keywords | PubMed ID |
去:0005576 | extracellular region | NAS | - | |
去:0005625 | 可溶部分 | IDA | 15300858 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER | 50 | 30 | All SZGR 2.0 genes in this pathway |
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
DURCHDEWALD SKIN CARCINOGENESIS DN | 264 | 168 | All SZGR 2.0 genes in this pathway |
HANN RESISTANCE TO BCL2 INHIBITOR DN | 48 | 31 | All SZGR 2.0 genes in this pathway |
MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
WAGSCHAL EHMT2 TARGETS UP | 13 | 7 | All SZGR 2.0 genes in this pathway |