Gene Page:CCDC88C
Summary?
| GeneID | 440193 |
| Symbol | CCDC88C |
| Synonyms | DAPLE|HKRP2|KIAA1509|SCA40 |
| Description | coiled-coil domain containing 88C |
| Reference | MIM:611204|HGNC:HGNC:19967|Ensembl:ENSG00000015133|Vega:OTTHUMG00000171099 |
| Gene type | protein-coding |
| Map location | 14q32.11 |
| Pascal p-value | 0.668 |
| Sherlock p-value | 0.844 |
| Fetal beta | 2.525 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans 元 |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10928544 | 14 | 91862864 | CCDC88C | 3.733E-4 | -0.646 | 0.043 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11160006 | chr14 | 91890676 | CCDC88C | 440193 | 0.12 | cis | ||
| rs10492950 | chr1 | 6006571 | CCDC88C | 440193 | 0.01 | trans | ||
| rs7524578 | chr1 | 6056728 | CCDC88C | 440193 | 0.09 | trans | ||
| rs16838771 | chr1 | 157511227 | CCDC88C | 440193 | 0.03 | trans | ||
| rs11943464 | chr4 | 23350098 | CCDC88C | 440193 | 0.09 | trans | ||
| rs1491136 | chr4 | 127646153 | CCDC88C | 440193 | 0.1 | trans | ||
| rs1491137 | chr4 | 127646180 | CCDC88C | 440193 | 0.1 | trans | ||
| rs285146 | chr5 | 55735499 | CCDC88C | 440193 | 0.15 | trans | ||
| rs474439 | chr5 | 103137012 | CCDC88C | 440193 | 0.18 | trans | ||
| rs7448080 | chr5 | 123398097 | CCDC88C | 440193 | 0.05 | trans | ||
| rs9397728 | chr6 | 150514248 | CCDC88C | 440193 | 0.19 | trans | ||
| rs16922710 | chr10 | 23087297 | CCDC88C | 440193 | 0.04 | trans | ||
| rs10508654 | chr10 | 23104638 | CCDC88C | 440193 | 0.01 | trans | ||
| rs7081986 | chr10 | 90807242 | CCDC88C | 440193 | 0.15 | trans | ||
| rs11018189 | chr10 | 129345787 | CCDC88C | 440193 | 0.11 | trans | ||
| rs11178165 | chr12 | 70669547 | CCDC88C | 440193 | 0.08 | trans | ||
| rs11178166 | chr12 | 70670585 | CCDC88C | 440193 | 0.08 | trans | ||
| rs443222 | chr16 | 83889679 | CCDC88C | 440193 | 0.01 | trans | ||
| rs824575 | chr16 | 83891459 | CCDC88C | 440193 | 0.01 | trans | ||
| rs16962554 | chr19 | 29590544 | CCDC88C | 440193 | 0 | trans | ||
| rs1883665 | chrX | 17650382 | CCDC88C | 440193 | 0 | trans | ||
| rs7062071 | chrX | 17724830 | CCDC88C | 440193 | 0.08 | trans | ||
| rs7879274 | chrX | 145592957 | CCDC88C | 440193 | 0.01 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| ROPERO HDAC2 TARGETS | 114 | 71 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 18HR DN | 178 | 121 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| CADWELL ATG16L1 TARGETS DN | 70 | 43 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |