SZGR2 - Beplay体育中心

Summary?

GeneID	4591
Symbol	TRIM37
Synonyms	MUL\|POB1\|TEF3
Description	tripartite motif containing 37
Reference	MIM:605073\|HGNC:HGNC:7523\|Ensembl:ENSG00000108395\|HPRD:05463\|Vega:OTTHUMG00000179360
Gene type	protein-coding
Map location	17q23.2
Pascal p-value	0.002
Sherlock p-value	0.424
DMG	1 (# studies)
eGene	Hippocampus
Support	CompositeSet Darnell FMRP targets Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	最短路径距离核心基因the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0074

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04504128	17	57183634	TRIM37	2.21E-8	-0.009	7.41E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	新闻学会		16189514
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Cellular component	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0005777	peroxisome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	Two-hybrid	BioGRID	16189514
BYSL	BYSTIN	bystin-like	Two-hybrid	BioGRID	16189514
COPB1	COPB \| DKFZp761K102 \| FLJ10341	coatomer protein complex, subunit beta 1	Two-hybrid	BioGRID	16189514
DLGAP5	DLG1 \| DLG7 \| HURP \| KIAA0008	discs, large (Drosophila) homolog-associated protein 5	Two-hybrid	BioGRID	16189514
EWSR1	EWS	Ewing sarcoma breakpoint region 1	Two-hybrid	BioGRID	16189514
FAM107A	DRR1 \| FLJ30158 \| FLJ45473 \| TU3A	family with sequence similarity 107, member A	Two-hybrid	BioGRID	16189514
FAM124B	FLJ22746	family with sequence similarity 124B	Two-hybrid	BioGRID	16189514
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
KIAA0408	FLJ43995 \| RP3-403A15.2	KIAA0408	Two-hybrid	BioGRID	16189514
MAGEB18	MGC33889	melanoma antigen family B, 18	Two-hybrid	BioGRID	16189514
MCM10	CNA43 \| DNA43 \| MGC126776 \| PRO2249	minichromosome maintenance complex component 10	Two-hybrid	BioGRID	16189514
MCRS1	ICP22BP \| INO80Q \| MCRS2 \| MSP58 \| P78	microspherule protein 1	Two-hybrid	BioGRID	16189514
NUDT18	FLJ22494	nudix (nucleoside diphosphate linked moiety X)-type motif 18	Two-hybrid	BioGRID	16189514
PBK	FLJ14385 \| Nori-3 \| SPK \| TOPK	PDZ binding kinase	Two-hybrid	BioGRID	16189514
PNKP	PNK	polynucleotide kinase 3'-phosphatase	Two-hybrid	BioGRID	16189514
PRC1	ASE1 \| MGC1671 \| MGC3669	protein regulator of cytokinesis 1	Affinity Capture-Western Two-hybrid	BioGRID	16189514
RHPN1	KIAA1929 \| ODF5 \| RHOPHILIN \| RHPN	rhophilin, Rho GTPase binding protein 1	Two-hybrid	BioGRID	16189514
RIBC2	C22orf11	RIB43A domain with coiled-coils 2	Two-hybrid	BioGRID	16189514
TCEB3B	ELOA2 \| HsT832 \| MGC119351 \| TCEB3L	transcription elongation factor B polypeptide 3B (elongin A2)	Two-hybrid	BioGRID	16189514
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD,BioGRID	11279055
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	11279055
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD,BioGRID	11279055
TRAF4	CART1 \| MLN62 \| RNF83	TNF receptor-associated factor 4	-	HPRD,BioGRID	11279055
TRAF5	MGC:39780 \| RNF84	TNF receptor-associated factor 5	-	HPRD,BioGRID	11279055
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	11279055
ZNF417	MGC34079	zinc finger protein 417	Two-hybrid	BioGRID	16189514
ZNF655	DKFZp686M1631 \| FLJ23461 \| MGC10859 \| MGC16203 \| MGC5521 \| VIK \| VIK-1	zinc finger protein 655	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	212	129	All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN	90	65	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN	167	100	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN	101	66	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN	129	86	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
GAZIN EPIGENETIC SILENCING BY KRAS	26	16	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 5	18	11	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-29	58	64	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

Gene Page:TRIM37