Gene Page:MYH9

Summary?
GeneID 4627
Symbol MYH9
Synonyms BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA
Description myosin, heavy chain 9, non-muscle
Reference MIM:160775|HGNC:HGNC:7579|Ensembl:ENSG00000100345|HPRD:01177|Vega:OTTHUMG00000030429
Gene type protein-coding
Map location 22q13.1
Pascal p-value 0.27
Sherlock p-value 0.714
TADA p-value 0.006
Fetal beta -0.846
eGene Myers' cis & trans
Meta
Support STRUCTURAL PLASTICITY
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
CompositeSet
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键字s: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0354

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
MYH9 chr22 36689894 C T NM_002473 p.1285V>M missense Schizophrenia DNM:Fromer_2014
MYH9 chr22 36714348 G A NM_002473 . silent Schizophrenia DNM:Fromer_2014
MYH9 chr22 36696896 C A NM_002473
NM_002473		 .
.		 intronic
splice-donor-in2		 Schizophrenia DNM:Gulsuner_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16827037 chr3 117203284 MYH9 4627 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000146 microfilament motor activity IDA 12237319
GO:0000166 nucleotide binding IEA -
GO:0003779 actin binding IEA -
GO:0003774 motor activity IEA -
GO:0005516 calmodulin binding IEA -
GO:0005524 ATP binding IDA 15065866|15845534
GO:0005524 ATP binding IEA -
去:0016887 ATPase activity IDA 12237319
GO:0043495 protein anchor IMP 16403913
GO:0051015 actin filament binding IDA 12237319|14508515
GO:0051015 actin filament binding NAS 16403913
GO:0042803 protein homodimerization activity IDA 12237319
GO:0030898 actin-dependent ATPase activity IDA 15065866|15845534
GO:0043531 ADP binding IDA 15065866
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000212 meiotic spindle organization IEA -
GO:0000904 cell morphogenesis involved in differentiation IEA -
GO:0000910 cytokinesis IMP 15774463
GO:0001525 angiogenesis IDA 16403913
GO:0001701 in utero embryonic development IEA -
GO:0001768 establishment of T cell polarity IEA -
GO:0030224 monocyte differentiation IEP 1912569
GO:0007132 meiotic metaphase I IEA -
GO:0006509 membrane protein ectodomain proteolysis IDA 16186248
GO:0007229 integrin-mediated signaling pathway NAS 10822899
GO:0008360 regulation of cell shape IMP 11029059
GO:0007605 sensory perception of sound IEA -
GO:0030048 actin filament-based movement IDA 12237319
GO:0007520 myoblast fusion IEA -
GO:0006928 cell motion IEA -
GO:0016337 信息adhesion IEA -
GO:0032796 uropod organization IEA -
GO:0015031 protein transport IMP 16403913
GO:0031532 actin cytoskeleton reorganization IMP 15869600
GO:0051295 establishment of meiotic spindle localization IEA -
GO:0030220 platelet formation IMP 12237319
GO:0043534 blood vessel endothelial cell migration IMP 16403913
GO:0050900 leukocyte migration NAS 12421915
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0001772 immunological synapse IDA Synap (GO term level: 7) 15064761
去:0031594 neuromuscular junction IEA neuron, axon, Synap, Neurotransmitter (GO term level: 3) -
GO:0001931 uropod IDA Synap (GO term level: 5) 15064761
GO:0001725 stress fiber IDA 7699007|14508515|14706930
|16403913
GO:0001726 ruffle IDA 16403913
GO:0005819 spindle IEA -
GO:0005826 contractile ring IDA 11029059
GO:0005829 cytosol IDA 14508515
GO:0005634 nucleus IDA 14508515
GO:0005737 cytoplasm IDA 7699007
GO:0005938 cell cortex IEA -
GO:0005913 cell-cell adherens junction IEA -
GO:0005886 plasma membrane IDA 16186248|16403913
GO:0008305 integrin complex IDA 10822899
GO:0016459 myosin complex IEA -
GO:0032154 cleavage furrow IDA 7699007|14508515
GO:0030863 cortical cytoskeleton IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 73 58 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 32 22 All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 27 21 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN 48 34 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191 128 All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 22 13 9 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR DN 20 12 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 103 71 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL TRANS 6 5 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 66 47 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP 17 13 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182 119 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN 53 40 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 95 64 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 96 71 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 28 18 All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 78 49 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN 50 33 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP 66 43 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE CURCUMIN SULINDAC TSA 1 10 7 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
IKEDA MIR133 TARGETS UP 43 27 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 183 189 1A hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-124.1 1297 1303 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1296 1303 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-133 787 794 1A,m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-142-3p 1324 1330 1A hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-149 833 839 1A hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-199 1075 1081 m8 hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-25/32/92/363/367 672 678 m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-30-5p 1339 1345 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-410 1283 1289 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-542-3p 1317 1323 m8 hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA
miR-9 226 233 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA