Gene Page:MYL2
Summary?
| GeneID | 4633 |
| Symbol | MYL2 |
| Synonyms | CMH10|MLC-2s/v|MLC2 |
| Description | myosin light chain 2 |
| Reference | MIM:160781|HGNC:HGNC:7583|Ensembl:ENSG00000111245|HPRD:01181|Vega:OTTHUMG00000169535 |
| Gene type | protein-coding |
| Map location | 12q24.11 |
| Pascal p-value | 0.128 |
| Fetal beta | 0.483 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| UPF2 | 0.90 | 0.91 |
| SBNO1 | 0.86 | 0.87 |
| ATP11B | 0.86 | 0.86 |
| C9orf102 | 0.86 | 0.86 |
| RANBP2 | 0.85 | 0.86 |
| TBL1XR1 | 0.85 | 0.85 |
| HOOK3 | 0.84 | 0.84 |
| TMF1 | 0.84 | 0.85 |
| MTDH | 0.84 | 0.86 |
| LIN54 | 0.84 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ENHO | -0.66 | -0.75 |
| CST3 | -0.63 | -0.68 |
| TLCD1 | -0.62 | -0.66 |
| S100A16 | -0.61 | -0.66 |
| METRN | -0.60 | -0.66 |
| HIGD1B | -0.60 | -0.66 |
| AF347015.31 | -0.60 | -0.66 |
| RHOC | -0.60 | -0.68 |
| FXYD1 | -0.60 | -0.64 |
| RAMP1 | -0.59 | -0.65 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CARDIAC MUSCLE CONTRACTION | 80 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
| KEGG TIGHT JUNCTION | 134 | 86 | All SZGR 2.0 genes in this pathway |
| KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | All SZGR 2.0 genes in this pathway |
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
| KEGG HYPERTROPHIC CARDIOMYOPATHY HCM | 85 | 65 | All SZGR 2.0 genes in this pathway |
| KEGG DILATED CARDIOMYOPATHY | 92 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA ALK PATHWAY | 37 | 29 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CCR3 PATHWAY | 23 | 21 | All SZGR 2.0 genes in this pathway |
| BIOCARTA ECM PATHWAY | 24 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MCALPAIN PATHWAY | 25 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MYOSIN PATHWAY | 31 | 22 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RAC1 PATHWAY | 23 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RHO PATHWAY | 32 | 23 | All SZGR 2.0 genes in this pathway |
| PID RHOA PATHWAY | 45 | 33 | All SZGR 2.0 genes in this pathway |
| PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
| PID THROMBIN PAR4 PATHWAY | 15 | 11 | All SZGR 2.0 genes in this pathway |
| PID ECADHERIN STABILIZATION PATHWAY | 42 | 34 | All SZGR 2.0 genes in this pathway |
| PID THROMBIN PAR1 PATHWAY | 43 | 32 | All SZGR 2.0 genes in this pathway |
| PID NCADHERIN PATHWAY | 33 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME STRIATED MUSCLE CONTRACTION | 27 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME MUSCLE CONTRACTION | 48 | 24 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC2 TARGETS DN | 133 | 77 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| RICKMAN HEAD AND NECK CANCER F | 54 | 32 | All SZGR 2.0 genes in this pathway |
| SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN | 36 | 24 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| RAMASWAMY METASTASIS DN | 61 | 47 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
| ZAMORA NOS2 TARGETS DN | 96 | 71 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS DN | 292 | 189 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 LCP WITH H3K27ME3 | 29 | 11 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES LCP WITH H3K27ME3 | 14 | 8 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS UP | 266 | 142 | All SZGR 2.0 genes in this pathway |
| CHEMELLO SOLEUS VS EDL MYOFIBERS UP | 35 | 16 | All SZGR 2.0 genes in this pathway |