Gene Page:MYO9B

Summary?
GeneID 4650
象征 MYO9B
Synonyms CELIAC4|MYR5
Description myosin IXB
Reference MIM:602129|HGNC:HGNC:7609|Ensembl:ENSG00000099331|HPRD:03677|Vega:OTTHUMG00000182707
Gene type protein-coding
Map location 19p13.1
Pascal p-value 0.288
Sherlock p-value 0.386
Fetal beta 0.727
eGene Myers' cis & trans
元
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Expression 元-analysis of gene expression Pvalue: 1.36
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

部分遗传学和epig ienetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25290657 19 17186505 HAUS8;MYO9B 4.545E-4 -0.353 0.045 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7830259 chr8 14087643 MYO9B 4650 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PWP1 0.95 0.95
TSR1 0.94 0.94
THUMPD3 0.93 0.93
CAPN7 0.93 0.94
C17orf71 0.93 0.94
PSPC1 0.93 0.94
PLRG1 0.93 0.93
SF3A3 0.92 0.93
SMARCA1 0.92 0.93
DIS3 0.92 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.82 -0.89
AF347015.31 -0.82 -0.88
AF347015.27 -0.79 -0.86
MT-CYB -0.79 -0.87
AF347015.33 -0.79 -0.86
AF347015.8 -0.78 -0.88
IFI27 -0.76 -0.83
AF347015.21 -0.75 -0.86
FXYD1 -0.75 -0.83
AF347015.15 -0.75 -0.86

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000146 microfilament motor activity IDA 9490638|11901422|16616011
GO:0000146 microfilament motor activity TAS 8907710
GO:0000166 nucleotide binding IEA -
GO:0005100 Rho GTPase activator activity IDA 9490638|15644318
GO:0003779 actin binding IDA 9490638|16338935|16616011
GO:0003774 motor activity IEA -
GO:0005096 GTPase activator activity IEA -
GO:0005516 calmodulin binding IDA 9490638|16338935
GO:0005524 ATP binding IDA 16338935
GO:0005524 ATP binding IEA -
GO:0008270 zinc ion binding IEA -
去:0016887 ATPase activity IDA 16338935
GO:0042803 protein homodimerization activity IDA 11901422
GO:0019992 diacylglycerol binding IEA -
GO:0046872 metal ion binding IEA -
GO:0043531 ADP binding IDA 16338935
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007242 intracellular signaling cascade IEA -
GO:0030048 actin filament-based movement TAS 8907710
GO:0032011 ARF protein signal transduction IDA 15644318
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005737 cytoplasm IDA 8907710
GO:0005938 cell cortex IDA 8907710
GO:0048471 perinuclear region of cytoplasm IDA 8907710
GO:0016459 myosin complex IEA -
GO:0031941 filamentous actin IDA 8907710|16338935|16616011

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID RHOA REG PATHWAY 46 30 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153 102 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER 94 60 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP 44 30 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 328 334 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA