Gene Page:ATF1

Summary?
GeneID 466
Symbol ATF1
Synonyms EWS-ATF1|FUS/ATF-1|TREB36
Description activating transcription factor 1
Reference MIM:123803|HGNC:HGNC:783|Ensembl:ENSG00000123268|HPRD:00440|Vega:OTTHUMG00000169482
Gene type protein-coding
Map location 12q13
Pascal p-value 5.016E-4
eGene Myers' cis & trans

基因数据来源
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 ATF1 466 0.07 trans
rs7584986 chr2 184111432 ATF1 466 0.07 trans
rs16955618 chr15 29937543 ATF1 466 0.07 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 -26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset - HPRD,BioGRID 10945975
CAMK2A CAMKA | KIAA0968 calcium/calmodulin-dependent protein kinase II alpha Biochemical Activity BioGRID 8663317
CREB1 CREB | MGC9284 cAMP responsive element binding protein 1 - HPRD,BioGRID 1655749|8384217
CREBBP CBP | KAT3A | RSTS CREB binding protein - HPRD,BioGRID 8663317
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide - HPRD,BioGRID 9685505
CSNK2A2 CK2A2 | CSNK2A1 | FLJ43934 casein kinase 2, alpha prime polypeptide - HPRD,BioGRID 9685505
CSNK2B CK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224 casein kinase 2, beta polypeptide Reconstituted Complex BioGRID 9685505
EDF1 EDF-1 | MBF1 | MGC9058 endothelial differentiation-related factor 1 - HPRD,BioGRID 10567391
FOSL1 FRA | FRA1 | fra-1 FOS-like antigen 1 ATF1interacts with the region of the FRA-1 promoter containing the SRE and ATF sites. BIND 15806162
GABPA E4TF1-60 | E4TF1A | NFT2 | NRF2 | NRF2A GA binding protein transcription factor, alpha subunit 60kDa - HPRD,BioGRID 10585419
GABPB1 BABPB2 | E4TF1 | E4TF1-47 | E4TF1-53 | E4TF1B | GABPB | GABPB2 | NRF2B1 | NRF2B2 GA binding protein transcription factor, beta subunit 1 - HPRD 10585419
HNF1B FJHN | HNF1beta | HNF2 | HPC11 | LF-B3 | LFB3 | MODY5 | TCF2 | VHNF1 HNF1 homeobox B 2台混合动力 BioGRID 9671480
JUN AP-1 | AP1 | c-Jun jun oncogene - HPRD,BioGRID 8570175
SPI1 OF | PU.1 | SFPI1 | SPI-1 | SPI-A spleen focus forming virus (SFFV) proviral integration oncogene spi1 - HPRD,BioGRID 7730336


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA应力路径 25 18 All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 45 35 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 38 29 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 24 20 All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 50 37 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209 122 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN 59 45 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 77 51 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 40 26 All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 21 9 5 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 50 35 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 64 44 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 11 57 40 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 69 38 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway