Gene Page:NEDD4

Summary?
GeneID 4734
Symbol NEDD4
Synonyms NEDD4-1|RPF1
Description neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Reference MIM:602278|HGNC:HGNC:7727|Ensembl:ENSG00000069869|HPRD:03786|Vega:OTTHUMG00000132015
Gene type protein-coding
Map location 15q
Pascal p-value 0.031
Fetal beta 0.738
Support G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0132

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BOC 0.73 0.53
PDLIM1 0.67 0.40
DCT 0.67 0.00
DPF3 0.66 0.38
COL2A1 0.66 0.49
HUNK 0.65 0.78
CDON 0.64 0.75
DUSP4 0.64 0.83
TNFRSF19 0.64 0.67
BHLHE22 0.63 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.41 -0.60
AIFM3 -0.41 -0.65
PTH1R -0.40 -0.59
HLA-F -0.40 -0.62
AF347015.27 -0.39 -0.72
MT-CO2 -0.39 -0.74
AF347015.31 -0.39 -0.71
AF347015.33 -0.38 -0.71
IFI27 -0.38 -0.72
LDHD -0.38 -0.51

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 17719543
GO:0004842 ubiquitin-protein ligase activity IEA -
GO:0016874 ligase activity IEA -
GO:0016881 acid-amino acid ligase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006464 蛋白质改性过程 IEA -
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000151 ubiquitin ligase complex IEA -
GO:0005829 cytosol IEA -
GO:0005622 intracellular IEA -
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANXA13 ANX13 | ISA | MGC150460 annexin A13 - HPRD,BioGRID 10871286
CBLB DKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56 Cas-Br-M (murine) ecotropic retroviral transforming sequence b - HPRD,BioGRID 12907674
CDC25C CDC25 cell division cycle 25 homolog C (S. pombe) - HPRD,BioGRID 10037602
DAZAP2 KIAA0058 | MGC14319 | MGC766 | PRTB DAZ associated protein 2 - HPRD 11342538
EPS15 AF-1P | AF1P | MLLT5 epidermal growth factor receptor pathway substrate 15 - HPRD,BioGRID 11919637
GRB10 GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSS growth factor receptor-bound protein 10 - HPRD 12697834
GRB10 GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSS growth factor receptor-bound protein 10 - HPRD 10446181|12697834|12697834
HGS HRS | ZFYVE8 hepatocyte growth factor-regulated tyrosine kinase substrate - HPRD,BioGRID 12230472
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 insulin-like growth factor 1 receptor - HPRD,BioGRID 12697834
LITAF FLJ38636 | MGC116698 | MGC116700 | MGC116701 | MGC125274 | MGC125275 | MGC125276 | PIG7 | SIMPLE | TP53I7 lipopolysaccharide-induced TNF factor - HPRD 11042109
N4BP2 B3BP | FLJ10680 | KIAA1413 NEDD4 binding protein 2 - HPRD 11717310
N4BP3 KIAA0341 Nedd4 binding protein 3 - HPRD,BioGRID 11717310
NDFIP1 MGC10924 | N4WBP5 Nedd4 family interacting protein 1 - HPRD 11042109|11748237
NDFIP2 FLJ25842 | KIAA1165 | N4wbp5a Nedd4 family interacting protein 2 - HPRD 12050153|12796489
|15252135|12796489
NDFIP2 FLJ25842 | KIAA1165 | N4wbp5a Nedd4 family interacting protein 2 - HPRD,BioGRID 12050153|12796489
|15252135
NFE2 NF-E2 | p45 nuclear factor (erythroid-derived 2), 45kDa p45 interacts with NEDD4. This interaction was modeled on a demonstrated interaction between human p45 and mouse NEDD4. BIND 9305852
PMEPA1 STAG1 | TMEPAI prostate transmembrane protein, androgen induced 1 - HPRD,BioGRID 11042109|12907594
PRRG2 PRGP2 proline rich Gla (G-carboxyglutamic acid) 2 - HPRD 11042109
SCNN1A ENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1 sodium channel, nonvoltage-gated 1 alpha - HPRD,BioGRID 10642508
SCNN1A ENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1 sodium channel, nonvoltage-gated 1 alpha - HPRD 10212229|10642508
|11359767|10642508
SCNN1B ENaCb | ENaCbeta | SCNEB sodium channel, nonvoltage-gated 1, beta - HPRD 10212229|10642508
|11359767|10642508
SCNN1B ENaCb | ENaCbeta | SCNEB sodium channel, nonvoltage-gated 1, beta - HPRD,BioGRID 10642508
SCNN1G ENaCg | ENaCgamma | PHA1 | SCNEG sodium channel, nonvoltage-gated 1, gamma - HPRD,BioGRID 10642508
SCNN1G ENaCg | ENaCgamma | PHA1 | SCNEG sodium channel, nonvoltage-gated 1, gamma - HPRD 10212229|10642508
|11359767|10642508
SGK1 SGK serum/glucocorticoid regulated kinase 1 - HPRD,BioGRID 11696533
SH3KBP1 CIN85 | GIG10 | MIG18 SH3-domain kinase binding protein 1 - HPRD,BioGRID 12218189
TP73 P73 tumor protein p73 p73-alpha interacts with an unspecified isoform of Nedd4. BIND 15678106
UBE2D2 E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) - HPRD,BioGRID 9182527
UBE2D3 E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5C ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) - HPRD,BioGRID 9990509
UBE2E1 UBCH6 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) - HPRD,BioGRID 9990509
UBE2L3 E2-F1 | L-UBC | UBCH7 | UbcM4 ubiquitin-conjugating enzyme E2L 3 - HPRD,BioGRID 9990509
WBP1 MGC15305 | WBP-1 WW domain binding protein 1 - HPRD 11042109
WBP2 MGC18269 | WBP-2 WW domain binding protein 2 - HPRD 11042109


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY 38 32 All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 46 39 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 66 45 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368 234 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN 110 64 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP 19 14 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 65 44 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 91 44 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 74 50 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 70 49 All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 50 36 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 UP 12 9 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 DN 46 29 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC2 39 25 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 116 87 All SZGR 2.0 genes in this pathway
杨BCL3目标了 364 236 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-128 381 387 1A hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-144 1112 1118 m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-27 381 388 1A,m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 942 949 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-376 1122 1128 1A hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-9 1048 1055 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA