Gene Page:NEUROD2

Summary?
GeneID 4761
Symbol NEUROD2
Synonyms NDRF|bHLHa1
Description neuronal differentiation 2
Reference MIM:601725|HGNC:HGNC:7763|HPRD:03429|
Gene type protein-coding
Map location 17q12
Pascal p-value 3.437E-4
Sherlock p-value 0.043
Fetal beta 2.13
DMG 1 (# studies)
eGene 元

基因数据来源
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccur High-throughput literature-search 系统的年代earch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 支安打与neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01293647 17 37764264 NEUROD2 -0.027 0.31 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HYAL2 0.68 0.71
CDC42EP4 0.63 0.66
SLC39A1 0.63 0.64
MKNK2 0.63 0.60
CORO1B 0.62 0.63
SEMA4B 0.61 0.65
XKR8 0.60 0.62
MAFF 0.60 0.62
RBM38 0.60 0.60
FADS2 0.60 0.62
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC104794.1 -0.52 -0.49
RERGL -0.51 -0.50
SYCP3 -0.50 -0.42
USMG5 -0.48 -0.52
C5orf53 -0.47 -0.46
PIGB -0.47 -0.49
SATL1 -0.44 -0.43
UROS -0.44 -0.41
MAEL -0.44 -0.46
LY96 -0.43 -0.44

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 8816493
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0048666 neuron development IEA neuron (GO term level: 9) -
GO:0007399 nervous system development TAS neurite (GO term level: 5) 8816493
GO:0001662 行为恐惧反应 IEA -
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8816493
GO:0008306 associative learning IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 133 78 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 93 56 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 1509 1515 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-137 762 769 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-153 845 852 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d 939 945 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-185 208 214 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-210 1171 1178 1A,m8 hsa-miR-210 CUGUGCGUGUGACAGCGGCUGA
miR-219 992 998 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-331 173 179 m8 hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-34/449 1027 1033 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-448 846 852 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-450 1509 1515 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
miR-496 1660 1666 1A hsa-miR-496 AUUACAUGGCCAAUCUC