Gene Page:NEUROG1

概括?
基因 4762
Symbol NEUROG1
Synonyms AKA|Math4C|NEUROD3|bHLHa6|ngn1
Description neurogenin 1
Reference MIM:601726|HGNC:HGNC:7764|Ensembl:ENSG00000181965|HPRD:03430|Vega:OTTHUMG00000129138
Gene type protein-coding
Map location 5q23-q31
Pascal p-value 0.094
DMG 1 (# studies)
eGene Myers' cis & trans
元

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0032
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:原理图izophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：2

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04063589 5 134871973 NEUROG1 1.82E-5 -0.266 0.016 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs13403353 chr2 144067716 NEUROG1 4762 0.13 trans
rs11190152 chr10 101325914 NEUROG1 4762 0.17 trans
rs17110779 chr14 26599617 NEUROG1 4762 0.11 trans
rs409642 chr20 54250273 NEUROG1 4762 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAP3K11 0.80 0.82
ARHGAP22 0.78 0.79
ASPHD1 0.77 0.76
GAS2L1 0.77 0.80
ZBTB47 0.77 0.76
GNPTG 0.76 0.79
leng3 0.76 0.76
PACSIN3 0.76 0.79
SLC9A3R2 0.76 0.76
AL132868.3 0.75 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC004017.1 -0.58 -0.48
KCNRG -0.57 -0.48
ZNF551 -0.57 -0.47
ZBED5 -0.56 -0.56
ZNF300 -0.56 -0.46
C11orf57 -0.56 -0.59
CYP2R1 -0.56 -0.57
KLHL1 -0.55 -0.44
ZNF124 -0.55 -0.50
AC005768.1 -0.55 -0.56

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 8816493
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0030182 neuron differentiation IEA neuron (GO term level: 8) -
GO:0007399 nervous system development TAS neurite (GO term level: 5) 8816493
去：0006357 regulation of transcription from RNA polymerase II promoter TAS 8816493
GO:0007275 multicellular organismal development IEA -
GO:0042472 inner ear morphogenesis IEA -
GO：0031536 positive regulation of exit from mitosis IEA -
GO:0045165 细胞命运承诺 IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID BETA CATENIN NUC PATHWAY 80 60 该途径中的所有SZGR 2.0基因
RIZ ERYTHROID DIFFERENTIATION 6HR 40 23 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
SHEPARD CRUSH AND BURN MUTANT DN 185 111 该途径中的所有SZGR 2.0基因
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 62 38 该途径中的所有SZGR 2.0基因
Lee Calorie限制新皮层DN 88 58 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 1 UP 125 61 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 3 UP 170 97 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 4 UP 112 64 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 7 UP 118 68 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-130/301 239 245 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-17-5p/20/93.mr/106/519.d 241 247 m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-204/211 319 325 m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-30-5p 645 651 1A HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA