Gene Page:NFATC2

Summary?
GeneID 4773
Symbol NFATC2
Synonyms NFAT1|NFATP
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Reference MIM:600490|HGNC:HGNC:7776|Ensembl:ENSG00000101096|HPRD:02730|Vega:OTTHUMG00000032747
Gene type protein-coding
Map location 20q13.2
Pascal p-value 0.714
Fetal beta -0.478

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0218

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC015656.1 0.91 0.81
GPR139 0.68 0.73
KLF11 0.67 0.72
LRRC55 0.66 0.75
FAM129B 0.66 0.75
EFNB2 0.66 0.72
AC023424.3 0.65 0.71
AC010974.2 0.65 0.76
LCMT2 0.65 0.74
AC010265.1 0.65 0.72
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.44 -0.71
CA4 -0.40 -0.58
PTH1R -0.40 -0.54
AF347015.31 -0.40 -0.71
ACOT13 -0.39 -0.60
AIFM3 -0.39 -0.56
RGN -0.39 -0.53
CMTM8 -0.39 -0.49
MT-CO2 -0.39 -0.70
TNFSF12 -0.39 -0.54

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 8668213
GO:0005515 protein binding 新闻学会 16873067
GO:0016563 transcription activator activity IDA 15790681
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001816 cytokine production IEA -
GO:0006355 regulation of transcription, DNA-dependent TAS 8668213
GO:0045941 positive regulation of transcription IDA 15790681
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 8668213
GO:0005737 cytoplasm TAS 8668213

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CREBBP CBP | KAT3A | RSTS CREB binding protein - HPRD,BioGRID 9625762
EGR1 AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225 early growth response 1 - HPRD 12560487
EGR4 NGFI-C | NGFIC | PAT133 early growth response 4 - HPRD 12560487
EP300 KAT3B | p300 E1A binding protein p300 - HPRD,BioGRID 9625762
FOS AP-1 | C-FOS v-fos FBJ murine osteosarcoma viral oncogene homolog - HPRD 8397339|12949493
IRF4 LSIRF | MUM1 interferon regulatory factor 4 - HPRD,BioGRID 11956291
MED31 3110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1 mediator complex subunit 31 Two-hybrid BioGRID 16169070
MEF2D DKFZp686I1536 myocyte enhancer factor 2D - HPRD,BioGRID 10944115
NFATC2 KIAA0611 | NFAT1 | NFATP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 - HPRD,BioGRID 12949493
NFATC2IP FLJ14639 | MGC126790 | MGC138387 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein - HPRD 8943202
PIN1 DOD | UBL5 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 - HPRD,BioGRID 11356192
PRKCZ PKC-ZETA | PKC2 protein kinase C, zeta - HPRD,BioGRID 12021260
SNRK DKFZp779A1866 | FLJ20224 | HSNFRK | KIAA0096 SNF related kinase - HPRD 10878360|12087103
TAF9 广告- 004 | AK6 | cgi - 137 | CINAP | CIP | MGC1603 | MGC3647 | MGC5067 | MGC:1603 | MGC:3647 | MGC:5067 | TAF2G | TAFII31 | TAFII32 | TAFIID32 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa - HPRD 10821850
VIM FLJ36605 vimentin Two-hybrid BioGRID 16169070
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide - HPRD,BioGRID 10611249
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide - HPRD,BioGRID 10611249


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 37 28 All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY 21 17 All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 41 30 All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 39 29 All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY 16 15 All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY 29 26 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY 23 16 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 49 37 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 32 26 All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY 47 39 All SZGR 2.0 genes in this pathway
PID FRA PATHWAY 37 28 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 29 23 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 136 80 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION APOBEC2 27 19 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS DN 97 51 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON 149 76 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 71 49 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP 73 53 All SZGR 2.0 genes in this pathway
B IWANAGA致癌作用Y KRAS PTEN UP 181 112 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE DN 57 36 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 35 16 All SZGR 2.0 genes in this pathway