Gene Page:ATP1A3

概括?
基因 478
象征 ATP1A3
Synonyms AHC2|CAPOS|DYT12|RDP
Description ATPase Na+/K+ transporting subunit alpha 3
Reference MIM：182350|HGNC：HGNC：801|Ensembl:ENSG00000105409|HPRD:01666|Vega:OTTHUMG00000137384
Gene type protein-coding
Map location 19q13.31
Pascal p-value 0.195
Sherlock p-value 0.461
Fetal beta -1.301
DMG 1 (# studies)
Support 离子平衡
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2CDB.HUMAN_MGLUR5
G2Cdb.human_Synaptosome
G2CDB.HUMANNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
COMPOSITESET
Darnell FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10657367 19 42497766 ATP1A3 1.268E-4 0.524 0.03 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IDH3A 0.92 0.91
AC005277.1 0.91 0.91
NAP1L2 0.90 0.94
MOAP1 0.90 0.91
NSF 0.90 0.90
MAP1A 0.90 0.89
MAPK9 0.90 0.92
NDRG3 0.90 0.88
SNX10 0.89 0.92
CNTNAP1 0.89 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.55 -0.60
NME4 -0.52 -0.60
RPL28 -0.48 -0.54
RPS19P3 -0.48 -0.53
HYAL2 -0.48 -0.46
RPL23A -0.47 -0.47
SH3BP2 -0.47 -0.46
RPL18 -0.47 -0.50
RPS16P1 -0.46 -0.53
RPL37 -0.46 -0.56

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005524 ATP binding IEA -
GO:0005524 ATP binding NAS 15260953
GO:0005391 sodium:potassium-exchanging ATPase activity IMP 15260953
GO:0016787 hydrolase activity IEA -
GO：0016820 水解酶活性,作用于酸酐,猫alyzing transmembrane movement of substances IEA -
GO:0015662 ATPase活性，与离子的跨膜运动耦合，磷酸化机制 IEA -
GO:0015077 monovalent inorganic cation transmembrane transporter activity IEA -
GO:0030955 potassium ion binding IEA -
GO：0031402 sodium ion binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0035235 ionotropic glutamate receptor signaling pathway IEA glutamate (GO term level: 8) -
GO:0008344 adult locomotory behavior IEA -
GO:0008542 视觉学习 IEA -
GO:0008152 metabolic process IEA -
GO:0007613 memory IEA -
GO:0006814 sodium ion transport IEA -
GO:0006813 potassium ion transport IEA -
GO:0042493 对药物的反应 IEA -
去：0030317 sperm motility ISS -
GO:0030641 regulation of cellular pH ISS -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IDA 15260953
GO:0005634 nucleus IEA -
GO:0005737 细胞质 IEA -
GO:0005783 endoplasmic reticulum IDA 15260953
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO：0016021 integral to membrane NAS 15260953
GO:0005886 plasma membrane IDA 15260953
GO:0005890 钠：钾交换ATPase复合物 IC 15260953

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CARDIAC MUSCLE CONTRACTION 80 51 该途径中的所有SZGR 2.0基因
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 该途径中的所有SZGR 2.0基因
KEGG PROXIMAL TUBULE BICARBONATE RECLAMATION 23 16 该途径中的所有SZGR 2.0基因
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 该途径中的所有SZGR 2.0基因
REACTOME ION TRANSPORT BY P TYPE ATPASES 34 21 该途径中的所有SZGR 2.0基因
REACTOME ION CHANNEL TRANSPORT 55 42 该途径中的所有SZGR 2.0基因
McBryan Pubertal乳房3 4WK 214 144 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL BREAST 5 6WK DN 137 97 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 该途径中的所有SZGR 2.0基因
SMITH TERT TARGETS DN 87 69 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 20HR UP 240 152 该途径中的所有SZGR 2.0基因
Chen LVAD支持失败的心脏DN 42 32 该途径中的所有SZGR 2.0基因
KUNINGER IGF1 VS PDGFB TARGETS DN 46 28 该途径中的所有SZGR 2.0基因
Bandres对Carmustin没有MGMT 48小时DN的响应 32 25 该途径中的所有SZGR 2.0基因
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 该途径中的所有SZGR 2.0基因
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154 101 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
CHEN METABOLIC SYNDROM NETWORK 1210 725 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE UP 857 456 该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS CALB1 CORR UP 548 370 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-185 168 174 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC