Gene Page:NFIC

Summary?
GeneID 4782
Symbol NFIC
Synonyms CTF|CTF5|NF-I|NFI
Description nuclear factor I/C (CCAAT-binding transcription factor)
Reference MIM:600729|HGNC:HGNC:7786|Ensembl:ENSG00000141905|Vega:OTTHUMG00000180731
Gene type protein-coding
Map location 19p13.3
Pascal p-value 0.219
Sherlock p-value 0.362
Fetal beta -0.889
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10712606 19 3367378 NFIC 1.785E-4 -0.551 0.034 DMG:Wockner_2014
cg25826463 19 3369820 NFIC 2.295E-4 -0.456 0.036 DMG:Wockner_2014
cg14101485 19 3369759 NFIC 3.845E-4 -0.546 0.043 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9659310 chr1 246014672 NFIC 4782 0.14 trans
rs6733654 chr2 1963270 NFIC 4782 0.02 trans
rs2712089 chr2 24080273 NFIC 4782 0.12 trans
rs1437904 chr2 133830789 NFIC 4782 0.09 trans
rs10176860 chr2 133841980 NFIC 4782 0.2 trans
rs6712415 chr2 133868796 NFIC 4782 0.03 trans
rs10184338 chr2 133868936 NFIC 4782 0.13 trans
rs10172235 chr2 133869155 NFIC 4782 0.18 trans
rs17029291 chr3 32402138 NFIC 4782 0 trans
rs2721884 chr8 133534264 NFIC 4782 0.17 trans
rs11073378 chr15 95227876 NFIC 4782 0.06 trans
rs6032293 chr20 44175130 NFIC 4782 0.04 trans
rs9637082 chr21 21213235 NFIC 4782 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID HNF3A PATHWAY 44 29 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN 44 30 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP 38 25 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN UP 19 12 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 91 64 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159 105 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C DN 59 39 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182 102 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway