Gene Page:NFKBIE

Summary?
GeneID 4794
Symbol NFKBIE
Synonyms IKBE
Description NFKB inhibitor epsilon
Reference MIM:604548|HGNC:HGNC:7799|Ensembl:ENSG00000146232|HPRD:05181|Vega:OTTHUMG00000014762
Gene type protein-coding
Map location 6p21.1
Pascal p-value 0.318
Sherlock p-value 0.012
Fetal beta 0.582
eGene Myers' cis & trans
元
Support G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0193

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6813178 chr4 71575238 NFKBIE 4794 0.2 trans
rs172650 chr16 71603911 NFKBIE 4794 0.18 trans
rs3829537 chr16 71612345 NFKBIE 4794 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NFATC1 0.62 0.59
SLC12A4 0.61 0.56
NKX2-2 0.61 0.57
HAP1 0.61 0.61
AC135457.1 0.59 0.67
HEY2 0.59 0.63
B3GNT9 0.59 0.65
ITPRIPL2 0.58 0.59
TIMP3 0.58 0.61
ITIH5 0.58 0.63
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NR2C2AP -0.42 -0.55
COMMD3 -0.40 -0.55
CYP2R1 -0.39 -0.55
POLB -0.39 -0.54
STMN1 -0.39 -0.48
ZNF32 -0.38 -0.54
ING4 -0.38 -0.51
BZW2 -0.38 -0.48
PARP6 -0.38 -0.45
DUSP12 -0.38 -0.49

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 16716191
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0042994 cytoplasmic sequestering of transcription factor TAS 9135156
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm TAS 9135156

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANKHD1 MASK | VBARP ankyrin repeat and KH domain containing 1 - HPRD 14743216
ANKHD1-EIF4EBP3 MASK-BP3 | MASK-BP3arf ANKHD1-EIF4EBP3 readthrough transcript - HPRD 14743216
ANKRD17 FLJ22206 | GTAR | KIAA0697 | NY-BR-16 ankyrin repeat domain 17 - HPRD 14743216
ANKRD28 KIAA0379 | PITK ankyrin repeat domain 28 - HPRD 14743216
ARHGEF2 DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40 rho/rac guanine nucleotide exchange factor (GEF) 2 - HPRD 14743216
HSPA8 HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 heat shock 70kDa protein 8 - HPRD 14743216
IL1A IL-1A | IL1 | IL1-ALPHA | IL1F1 interleukin 1, alpha - HPRD 10998424
JUP ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB junction plakoglobin Two-hybrid BioGRID 16189514
NFKB1 DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 - HPRD 9223487
NFKB1 DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 9315679
NFKB2 LYT-10 | LYT10 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) p52 interacts with I-kappa-B-epsilon. This interaction was modeled on a demonstrated interaction between p52 from an unspecified species and human I-kappa-B-epsilon. BIND 9135156
NFKB2 LYT-10 | LYT10 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) - HPRD,BioGRID 9315679
REL C-Rel v-rel reticuloendotheliosis viral oncogene homolog (avian) Affinity Capture-Western
Reconstituted Complex		 BioGRID 8415639|9315679
|10706725
REL C-Rel v-rel reticuloendotheliosis viral oncogene homolog (avian) - HPRD 8139561|8415639
|10706725
RELA MGC131774 | NFKB3 | p65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 9315679
RUVBL2 CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B RuvB-like 2(大肠杆菌) - HPRD 14743216
SAPS1 KIAA1115| MGC138185 | MGC142003 | PP6R1 | SAP190 SAPS domain family, member 1 - HPRD 14743216
SAPS2 KIAA0685 | PP6R2 | SAP190 | dJ579N16.1 SAPS domain family, member 2 - HPRD 14743216
SAPS3 C11orf23 | DKFZp781E17107 | DKFZp781E2374 | DKFZp781O2362 | FLJ11058 | FLJ43065 | KIAA1558 | MGC125711 | MGC125712 | PP6R3 | SAP190 | SAPL | SAPLa SAPS domain family, member 3 - HPRD 14743216
TUBA3C TUBA2 | bA408E5.3 tubulin, alpha 3c - HPRD 14743216
UACA FLJ10128 | KIAA1561 | MGC141967 | MGC141969 | NUCLING uveal autoantigen with coiled-coil domains and ankyrin repeats - HPRD 14743216


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 29 20 All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP 34 28 All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY 28 22 All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 37 32 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 97 66 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 64 43 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应我MUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
GILMORE CORE NFKB PATHWAY 14 10 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 66 48 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 100 68 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 38 25 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 101 76 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D CLUSTER DN 40 26 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D DN 78 34 All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 77 56 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 50 35 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240 153 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS DN 54 38 All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING VIA NFKB 28 21 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 53 34 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway