Gene Page:NFYA

Summary？
基因 4800
象征 NFYA
Synonyms CBF-A|CBF-B|HAP2|NF-YA
Description 核转录因子y亚基α
Reference MIM：189903|HGNC:HGNC:7804|HPRD:01793|
基因类型 蛋白质编码
Map location 6p21.3
Pascal p-value 0.497
胎儿β 1.563
DMG 1(# studies)
主持人 小脑

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 1
GSMA_I Genome scan meta-analysis Psr: 0.033
gsma_iie Genome scan meta-analysis (European-ancestry samples) PSR：0.04433

Section I. Genetics and epigenetics annotation

@不同甲基化基因

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG12694820 6 41041189 NFYA 1.6e-8 -0.01 5.94E-6 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
NME1-NME2 0.98 0.98
C2orf79 0.89 0.91
myl6 0.89 0.89
NME2P1 0.89 0.84
RPL12 0.89 0.83
COMMD6 0.86 0.84
RPL36 0.86 0.81
TCTEX1D2 0.85 0.84
RP11-544M22.1 0.85 0.83
UFC1 0.85 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
MYH14 -0.53 -0.65
AF347015.26 -0.53 -0.65
AF347015.33 -0.51 -0.61
EPAS1 -0.51 -0.61
KIF1C -0.51 -0.65
ZBTB7B -0.51 -0.62
AF347015.15 -0.51 -0.60
AF347015.27 -0.50 -0.59
FYCO1 -0.50 -0.61
AF347015.8 -0.50 -0.58

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003700 转录factor activity TAS 1774067|2000400
去：0005515 蛋白质结合 IPI 10571058|12659632|12741956
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006355 调节转录，DNA依赖性的调节 IDA 15243141
去：0006350 转录 IEA -
去：0006366 RNA聚合酶II启动子的转录 TAS 2000400
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IDA 15243141
GO:0016602 CCAAT结合因子复合物 IDA 15243141

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
APPBP2 HS.84084 | KIAA0228 | PAT1 淀粉样β前体蛋白（细胞质尾巴）结合蛋白2 Two-hybrid Biogrid 16189514
ATF6 ATF6A activating transcription factor 6 Two-hybrid Biogrid 11158310
ATF6B CREB-RP | CREBL1 | FLJ10066 | G13 activating transcription factor 6 beta Two-hybrid Biogrid 11158310
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 乳腺癌1，早发 - HPRD,BioGRID 11777930
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 乳腺癌1，早发 BRCA1 interacts with NF-YA 绑定 11777930
ELF1 - E74样因子1（ETS域转录因子） 重构的复合物 Biogrid 9668064
HMGA1 HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854 high mobility group AT-hook 1 - HPRD,BioGRID 9388234
六月 AP-1 |AP1 |C-Jun jun oncogene 亲和力捕获 - 韦斯特恩 Biogrid 11903046
NFYB CBF-A | CBF-B | HAP3 | NF-YB 核转录因子y，beta - HPRD,BioGRID 8051128
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 - HPRD 11777930
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 OCT-1与NF-YA相互作用 绑定 11777930
SPI1 OF | PU.1 | SFPI1 | SPI-1 | SPI-A 脾脏焦点形成病毒（SFFV）前病毒整合Oncogene SPI1 重构的复合物 Biogrid 9668064
SRF MCM1 血清反应因子（C-FOS血清响应元件结合转录因子） NF-YA与SRF相互作用。这种相互作用是建立在未指定物种和人类SRF之间的NF-YA之间的相互作用上建模的。 绑定 10571058
SRF MCM1 血清反应因子（C-FOS血清响应元件结合转录因子） 重构的复合物
Two-hybrid		 Biogrid 10571058
ZHX1 - zinc fingers and homeoboxes 1 NF-YA与ZHX1相互作用。这种相互作用是建立在未指定物种和人类ZHX1之间的NF-YA之间的相互作用上建模的。 绑定 10571058
ZHX1 - zinc fingers and homeoboxes 1 - HPRD,BioGRID 10441475|10571058
ZHX2 AFR1 | KIAA0854 | RAF zinc fingers and homeoboxes 2 - HPRD 12741956
ZHX3 KIAA0395 |TIX1 zinc fingers and homeoboxes 3 - HPRD 12659632


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG抗原处理和演示 89 65 All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
Reactome Ppara激活基因表达 104 72 All SZGR 2.0 genes in this pathway
Reactome糖尿病途径 133 91 All SZGR 2.0 genes in this pathway
Reactome Perk调控基因表达 29 14 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA 13 9 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4 26 12 All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 80 51 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA 11 8 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
反应组脂肪酸三酰甘油和酮体代谢 168 115 All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn 493 298 All SZGR 2.0 genes in this pathway
Puiffe入侵被腹水DN抑制 145 91 All SZGR 2.0 genes in this pathway
Casorelli急性临时细胞白血病 177 110 All SZGR 2.0 genes in this pathway
奥斯曼膀胱癌DN 406 230 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREEN DN 25 12 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
Kim WT1目标8小时DN 129 84 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络 423 265 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力 811 508 All SZGR 2.0 genes in this pathway
里克曼肿瘤区分良好，而不是很差 236 139 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发6小时DN 514 330 All SZGR 2.0 genes in this pathway
Georges细胞周期miR192目标 62 46 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞QTL顺式 128 77 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植OK vs供体DN 41 30 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK 63 48 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
Kang氟尿嘧啶抵抗DN 16 10 All SZGR 2.0 genes in this pathway
XU GH1外源目标 85 50 All SZGR 2.0 genes in this pathway
李小脑老化 84 58 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激 728 415 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
伽玛辐射2G后的生存率不佳 171 96 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C簇 38 26 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C UP 47 29 All SZGR 2.0 genes in this pathway
Browne HCMV感染30分钟DN 150 99 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 DN 336 211 All SZGR 2.0 genes in this pathway
SPI1和FLI1 DN的Juban目标 92 60 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-132/212 221 227 M8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-200bc/429 142 149 1A，M8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-22 1274 1280 M8 hsa-miR-22brain Aagcugccaguugaagaacugu
mir-330 686 692 1a hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-504 1390 1397 1A，M8 hsa-miR-504 agacccugucugcacucuau
miR-93.hd/291-3p/294/295/302/372/373/520 294 301 1A，M8 HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu