Gene Page:NGF

Summary?
GeneID 4803
Symbol NGF
Synonyms Beta-NGF|HSAN5|NGFB
Description nerve growth factor
Reference MIM:162030|HGNC:HGNC:7808|Ensembl:ENSG00000134259|HPRD:08874|Vega:OTTHUMG00000011880
Gene type protein-coding
Map location 1p13.1
Pascal p-value 1.079E-5
Fetal beta -0.354
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs537914 chr1 182492679 NGF 4803 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005057 receptor signaling protein activity IEA -
GO:0005163 nerve growth factor receptor binding IPI 14985763
GO:0008083 growth factor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0046928 regulation of neurotransmitter secretion IEA Synap, Neurotransmitter (GO term level: 9) -
GO:0045773 积极regulation of axon extension IEA axon (GO term level: 15) -
GO:0045664 调节神经元分化 IEA neuron, neurogenesis (GO term level: 9) -
GO:0007169 跨膜受体蛋白酪氨酸激酶e signaling pathway EXP 16939974
GO:0007265 Ras protein signal transduction EXP 11520933
GO:0007422 peripheral nervous system development IEA -
GO:0019233 sensory perception of pain IEA -
GO:0032455 nerve growth factor processing EXP 12787574
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005796 Golgi lumen EXP 8615794|12787574
GO:0005576 extracellular region EXP 11157096|12787574|16284401
GO:0005576 extracellular region IEA -
GO:0005768 endosome EXP 7806500|9182757|10629055
|16284401

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 88 62 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY 28 22 All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY 18 13 All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY 11 11 All SZGR 2.0 genes in this pathway
BIOCARTA TRKA PATHWAY 12 10 All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR 17 15 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 69 51 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 36 31 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 13 7 All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION 38 29 All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 12 8 All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB 14 10 All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 43 33 All SZGR 2.0 genes in this pathway
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 15 10 All SZGR 2.0 genes in this pathway
REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL 11 8 All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS DN 39 24 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 74 40 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 33 22 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 109 68 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 62 42 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 37 27 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199 143 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway