SZGR2 - Beplay体育中心

Summary？

基因	4804
象征	NGFR
Synonyms	CD271 \| gp80-lngfr \| tnfrsf16 \| p75（ntr）\| p75ntr
Description	神经生长因子受体
Reference	MIM:162010\|HGNC:HGNC:7809\|Ensembl:ENSG00000064300\|HPRD：01197\|Vega:OTTHUMG00000161495
基因类型	蛋白质编码
Map location	17q21-Q22
Pascal p-value	0.328
胎儿β	0.618
主持人	Putamen basal ganglia

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关关键字的命中：2

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS9908695	17	47550976	NGFR	ENSG00000064300.4	2.01019E-6	0.01	-21679	gtex_brain_putamen_basal
RS1317636	17	47551127	NGFR	ENSG00000064300.4	4.19031E-7	0.01	-21528	gtex_brain_putamen_basal
RS871882	17	47552043	NGFR	ENSG00000064300.4	4.66135E-7	0.01	-20612	gtex_brain_putamen_basal
RS62077745	17	47552169	NGFR	ENSG00000064300.4	1.65035E-6	0.01	-20486	gtex_brain_putamen_basal
RS62077746	17	47553947	NGFR	ENSG00000064300.4	2.12322 e-6	0.01	-18708	gtex_brain_putamen_basal
RS62077747	17	47555501	NGFR	ENSG00000064300.4	2.24691E-6	0.01	-17154	gtex_brain_putamen_basal
rs58700210	17	47556197	NGFR	ENSG00000064300.4	2.30671E-6	0.01	-16458	gtex_brain_putamen_basal
RS2001868	17	47559207	NGFR	ENSG00000064300.4	1.26252E-6	0.01	-13448	gtex_brain_putamen_basal
RS2584667	17	47560071	NGFR	ENSG00000064300.4	1.22511E-6	0.01	-12584	gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的Correlation
MRPS25	0.85	0.85
C17orf79	0.85	0.87
TPI1	0.84	0.86
MECR	0.84	0.85
snrpn	0.83	0.85
ndufa8	0.83	0.85
SNX17	0.82	0.84
Stub1	0.82	0.84
TMEM111	0.82	0.84
DHRS7B	0.82	0.85

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的Correlation
MAP4K4	-0.44	-0.41
thoc2	-0.43	-0.40
TTC28	-0.43	-0.28
ATAD2B	-0.43	-0.35
AC005035.1	-0.43	-0.41
GJC1	-0.42	-0.36
EIF2C4	-0.42	-0.25
SRGAP1	-0.42	-0.27
NHSL1	-0.42	-0.37
MBTD1	-0.42	-0.25

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0003824	催化活性	IEA		-
去：0005035	death receptor activity	IEA		-
去：0005515	蛋白质结合	IEA		-
GO:0048406	神经生长因子结合	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0007417	central nervous system development	IEA	大脑（GO期限：6）	-
去：0007411	轴突指导	IEA	axon (GO term level: 13)	-
GO：0016048	detection of temperature stimulus	IEA		-
GO:0006917	诱导凋亡	IEA		-
GO:0007165	信号转导	IEA		-
GO:0006915	凋亡	IEA		-
GO:0007275	multicellular organismal development	IEA		-
GO:0030154	细胞分化	IEA		-
GO：0021675	nerve development	IEA		-
GO:0042488	含牙本牙齿的牙生物的阳性调节	IEA		-
GO：0043588	skin development	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005634	nucleus	IDA		18029348
去：0005737	cytoplasm	IDA		18029348
去：0005886	plasma membrane	TAS		3022937
去：0005887	integral to plasma membrane	TAS		3022937

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
CAV1	cav \|MSTP085 \|VIP21	小窝蛋白1，小窝蛋白，22KDA	重构的复合物	Biogrid	9867838
FSCN1	FLJ38511 \|SNL \|p55	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	亲和力捕获 - 韦斯特恩重构的复合物 Two-hybrid	Biogrid	12789270
Kidins220	ARMS \| MGC163482	激酶D相互作用底物，220KDA	-	HPRD	11150334\|15378608
lingo1	FLJ14594 \| LERN1 \| LRRN6A \| MGC17422 \| UNQ201	含亮氨酸丰富的重复和IG结构域包含1	LINGO-1 interacts with p75. This interaction was modeled on a demonstrated interaction between LINGO-1 from human and p75 from rat.	绑定	14966521
杂志	GMA \|s-mag \|SIGLEC-4A \|siglec4a	myelin associated glycoprotein	-	HPRD	12011108
杂志ED1	DLXIN-1 \|nrage	melanoma antigen family D, 1	亲和力捕获 - 韦斯特恩	Biogrid	12716928
Mageh1	APR-1 \|APR1 \|Mageh	黑色素瘤抗原家族H，1	亲和力捕获 - 韦斯特恩	Biogrid	12414813
NDN	HST16328 \|pwcr	NECDIN同源物（鼠标）	-	HPRD,BioGRID	12414813\|12716928 \|14593116
ndnl2	HCA4 \|Mageg1 \|MAGEL3 \|NSE3 \|NSMCE3	necdin-like 2	亲和力捕获 - 韦斯特恩重构的复合物 Two-hybrid	Biogrid	14593116
NGF	Beta-NGF \| HSAN5 \| MGC161426 \| MGC161428 \| NGFB	nerve growth factor (beta polypeptide)	-	HPRD,BioGRID	14985763
NGF	Beta-NGF \| HSAN5 \| MGC161426 \| MGC161428 \| NGFB	nerve growth factor (beta polypeptide)	NGF与P75NTR相互作用。	绑定	14985763
NGF	Beta-NGF \| HSAN5 \| MGC161426 \| MGC161428 \| NGFB	nerve growth factor (beta polypeptide)	p75NTR interacts with NGF.	绑定	15258592
NGFRAP1	BEX3 \| Bex \| DXS6984E \| HGR74 \| NADE	神经生长因子受体（TNFRSF16）相关蛋白1	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	10764727
NTF4	NT-4/5 \| NT4 \| NT5 \| NTF5	neurotrophin 4	P75NTR与NT-4相互作用。	绑定	15258592
Prkacb	DKFZP781I2452 \|MGC41879 \|MGC9320 \|PKACB	蛋白激酶，cAMP依赖性，催化，β	亲和力捕获 - 韦斯特恩生化活动 Two-hybrid	Biogrid	12682012
rtn4r	ngr \|Nogor	网状4受体	P75与NGR相互作用。这种相互作用是根据未指定物种的P75和NGR之间的相互作用进行建模的。	绑定	15953414
rtn4r	ngr \|Nogor	网状4受体	P75与NGR相互作用。This interaction was modelled on a demonstrated interaction between rat p75 and human NgR.	绑定	15694321
rtn4r	ngr \|Nogor	网状4受体	-	HPRD	12422217
rtn4r	ngr \|Nogor	网状4受体	P75与NGR1相互作用。这种相互作用是在人类大鼠和NGR1的p75之间的相互作用上建模的。	绑定	14966521
SFRS10	DKFZp686F18120 \| Htra2-beta \| SRFS10 \| TRA2-BETA \| TRA2B \| TRAN2B	剪接因子，精氨酸/丝氨酸富10（变压器2同源物，果蝇）	-	HPRD	12604596
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	-	HPRD,BioGRID	7541035
SORT1	Gp95 \| NT3	Tortilin 1	P75NTR与Tortilin相互作用。这种相互作用是基于从人类和未指定物种的p75NTR与Tortilin之间的相互作用进行建模的。	绑定	14985763
传统	HS.89862 \|MGC11078	TNFRSF1A-associated via death domain	亲和力捕获 - 韦斯特恩	Biogrid	12604596
传统	HS.89862 \|MGC11078	TNFRSF1A-associated via death domain	传统interacts with NGFR (p75NTR).	绑定	12604596
traf1	EBI6 \|MGC：10353	TNF receptor-associated factor 1	亲和力捕获 - 韦斯特恩	Biogrid	10514511
traf2	MGC：45012 \|陷阱\|陷阱3	TNF receptor-associated factor 2	-	HPRD,BioGRID	10514511
traf3	CAP-1 \|CD40BP \|craf1 \|LAP1	TNF receptor-associated factor 3	亲和力捕获 - 韦斯特恩	Biogrid	10514511
traf4	CART1 \| MLN62 \| RNF83	TNF receptor-associated factor 4	-	HPRD,BioGRID	10514511
traf5	MGC:39780 \| RNF84	TNF receptor-associated factor 5	亲和力捕获 - 韦斯特恩	Biogrid	10514511
traf6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	10514511

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
Biocarta CDK5途径	11	11	All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR	17	15	All SZGR 2.0 genes in this pathway
PID P75 NTR途径	69	51	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	8	All SZGR 2.0 genes in this pathway
Reactome调节的p75NTR蛋白水解	10	9	All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB	14	10	All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	43	33	All SZGR 2.0 genes in this pathway
Reactome NRIF信号是细胞核的细胞死亡	15	10	All SZGR 2.0 genes in this pathway
Reactome NFKB被激活并信号存活	11	8	All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	60	43	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
Lee神经Crest干细胞向上	146	99	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
Perez TP53和TP63目标	205	145	All SZGR 2.0 genes in this pathway
Kobayashi对romidepsin的反应	19	14	All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏2	30	24	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM4	261	153	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM5	94	59	All SZGR 2.0 genes in this pathway
Bertucci侵入性癌导管与小叶DN	46	34	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
Chiba对TSA的反应	52	33	All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER	50	30	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
Bild MYC致癌签名	206	117	All SZGR 2.0 genes in this pathway
de yy1靶向	20	14	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN	546	362	All SZGR 2.0 genes in this pathway
SEKI炎症反应LPS	77	56	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病	181	106	All SZGR 2.0 genes in this pathway
Mikkelsen NPC HCP，带有H3K4ME3和H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-1/206	30	36	M8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	Uggaauguaaggaagugugugg
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-128	429	436	1A，M8	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	429	436	1A，M8	hsa-miR-128b	ucacagugaaccggucuuc
miR-143	261	267	1A	HSA-MIR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-27	430	437	1A，M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	430	437	1A，M8	HSA-MIR-27B^brain	UUCACAGUGGCUAAGUUCUGC
mir-299-3p	27	33	M8	hsa-miR-299-3p	UAUGUGGGAUGGUAAACCGCUU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:NGFR