Gene Page:NHLH2

概括?
GeneID 4808
Symbol NHLH2
同义词 HEN2|NSCL2|bHLHa34
描述 nescient helix-loop-helix 2
参考 MIM:162361|HGNC：HGNC：7818|Ensembl:ENSG00000177551|HPRD:01213|Vega:OTTHUMG00000011969
Gene type protein-coding
Map location 1p12-p11
Pascal p-value 0.028
Fetal beta 1.077
DMG 1（＃研究）
eGene Anterior cingulate cortex BA24
Cortex

数据源中的基因
基因集名称 Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I 基因组扫描荟萃分析 Psr: 0.0235
GSMA_IIA 基因组扫描荟萃分析(All samples) Psr: 0.00814
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
CG24999518 1 116381079 NHLH2 1.15E-9 -0.022 1.25E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs12029349 1 116372092 NHLH2 ENSG00000177551.5 1.787E-6 0.02 14446 gtex_brain_ba24
RS2797201 1 116372190 NHLH2 ENSG00000177551.5 7.548E-7 0.02 14348 gtex_brain_ba24
rs12031681 1 116372710 NHLH2 ENSG00000177551.5 1.794E-6 0.02 13828 gtex_brain_ba24
rs2797199 1 116372907 NHLH2 ENSG00000177551.5 7.617E-7 0.02 13631 gtex_brain_ba24
rs1891510 1 116373179 NHLH2 ENSG00000177551.5 1.807E-6 0.02 13359 gtex_brain_ba24
rs2797197 1 116373295 NHLH2 ENSG00000177551.5 7.678E-7 0.02 13243 gtex_brain_ba24
RS10923572 1 116374201 NHLH2 ENSG00000177551.5 1.806E-6 0.02 12337 gtex_brain_ba24
rs1970552 1 116374340 NHLH2 ENSG00000177551.5 7.398E-7 0.02 12198 gtex_brain_ba24
rs1891509 1 116374399 NHLH2 ENSG00000177551.5 7.172E-7 0.02 12139 gtex_brain_ba24
rs6670319 1 116374729 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11809 gtex_brain_ba24
rs6662619 1 116374902 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11636 gtex_brain_ba24
rs6662743 1 116375007 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11531 gtex_brain_ba24
rs6701873 1 116375163 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11375 gtex_brain_ba24
rs6701880 1 116375189 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11349 gtex_brain_ba24
RS6670890 1 116375318 NHLH2 ENSG00000177551.5 1.802E-6 0.02 11220 gtex_brain_ba24
rs1573105 1 116375415 NHLH2 ENSG00000177551.5 7.641E-7 0.02 11123 gtex_brain_ba24
rs200113545 1 116482634 NHLH2 ENSG00000177551.5 1.562E-6 0.02 -96096 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EHMT2 0.92 0.94
VPS16A 0.92 0.92
RBM10 0.92 0.93
C7orf26 0.91 0.91
DAXX 0.91 0.91
CXXC1 0.91 0.92
ATRIP 0.91 0.90
USF1 0.91 0.89
ZBTB17 0.91 0.92
PRPF31 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.80 -0.87
AF347015.27 -0.79 -0.87
MT-CO2 -0.78 -0.86
AF347015.33 -0.76 -0.84
AF347015.8 -0.75 -0.84
MT-CYB -0.74 -0.83
AF347015.21 -0.73 -0.90
IFI27 -0.73 -0.83
COPZ2 -0.72 -0.78
AF347015.15 -0.72 -0.82

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0030528 转录调节器活性 IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007417 中枢神经系统发展 塔斯 Brain (GO term level: 6) 1328219
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0007617 交配行为 IEA -
GO:0007275 多细胞生物发育 IEA -
GO:0030154 cell differentiation IEA -
GO:0042698 排卵周期 IEA -
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
ODONNELL TFRC TARGETS UP 456 228 该途径中的所有SZGR 2.0基因
LEE NEURAL CREST STEM CELL UP 146 99 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS UP 293 179 该途径中的所有SZGR 2.0基因
Martoriati MDM4靶向神经上皮DN 164 111 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 该途径中的所有SZGR 2.0基因
DAIRKEE TERT TARGETS UP 380 213 该途径中的所有SZGR 2.0基因
HATADA METHYLATED IN LUNG CANCER UP 390 236 该途径中的所有SZGR 2.0基因
Kannan TP53目标 58 40 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 该途径中的所有SZGR 2.0基因
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN 60 45 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
DELACROIX RAR BOUND ES 462 273 该途径中的所有SZGR 2.0基因
Smirnov对IR 6小时的回应 166 97 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

心肌梗死RNA family Target position mirna id 心肌梗死RNA seq
UTR start UTR end Match method
mir-128 618 624 m8 HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
心肌梗死R-130/301 1014 1020 m8 hsa-miR-130a脑 CAGUGCAAUGUUAAAAGGGCAU
HSA-MIR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130b脑 CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
心肌梗死R-142-5p 1471 1477 1A hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
心肌梗死R-216 975 982 1A,m8 HSA-MIR-216 UAAUCUCAGCUGGCAACUGUG
心肌梗死R-25/32/92/363/367 1481 1487 1A HSA-MIR-25脑 CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
心肌梗死R-27 1364 1370 1A hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 UUCACAGUGGCUAAGUUCUGC
心肌梗死R-30-5p 923 930 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
HSA-MIR-30C脑 uguaaacauccuacucucucucucagc
HSA-MIR-30DSZ uguaaacauccccgacuggaag
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
心肌梗死R-33 1479 1485 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
HSA-MIR-33B Gugcauugcuguugcauugca
心肌梗死R-342 1102 1108 1A HSA-MIR-342脑 UCUCACACAGAAAUCGCACCCGUC
心肌梗死R-369-3p 1130 1136 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
mir-374 1130 1136 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
心肌梗死R-410 1473 1479 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
心肌梗死R-431 852 858 1A HSA-MIR-431 UGUCUUGCAGGCCGUCAUGCA
mir-488 417 424 1A,m8 hsa-miR-488 CCCAGAUAAUGGCACUCUCAA
mir-494 1347 1354 1A,m8 hsa-miR-494脑 UGAAACAUACACGGGAAACCUCUU
mir-495 969 975 m8 hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
心肌梗死R-9 1427 1433 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
心肌梗死R-96 900 906 m8 hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC