Gene Page:NME1

Summary？
基因 4830
象征 NME1
Synonyms AWD|GAAD|NB|NBS|NDKA|NDPK-A|NDPKA|NM23|NM23-H1
Description NME/NM23核苷双磷酸激酶1
Reference MIM：156490|HGNC:HGNC:7849|Ensembl:ENSG00000239672|HPRD：01131|Vega：Otthumg00000137474
基因类型 蛋白质编码
Map location 17q21.3
Pascal p-value 0.026
主持人 元
Support 细胞代谢
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
SAT2 0.66 0.68
ADCK5 0.65 0.70
马夫 0.63 0.65
CCDC109B 0.62 0.55
macrod1 0.61 0.58
NCAPH2 0.61 0.61
黑手党 0.61 0.67
DUSP23 0.61 0.57
Flywch2 0.61 0.55
RNF215 0.61 0.67
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
mt-cyb -0.43 -0.36
MT-CO2 -0.42 -0.34
AF347015.26 -0.42 -0.37
AF347015.8 -0.42 -0.34
AF347015.33 -0.41 -0.33
AF347015.27 -0.41 -0.34
AF347015.15 -0.40 -0.34
AF347015.31 -0.40 -0.33
AF347015.2 -0.40 -0.32
MT-ATP8 -0.38 -0.37

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
Apex1 猿|ape-1 |APE1 |apen |顶点|APX |hap1 |ref-1 |参考文献1 顶点核酸酶（多功能DNA修复酶）1 - HPRD 12524539
AURKA aik |ark1 |光环|Aurora2 |btak |MGC34538 |STK15 |stk6 |STK7 Aurora激酶A。 - HPRD,BioGRID 12490715
CNKSR1 CNK |CNK1 |KSR connector enhancer of kinase suppressor of Ras 1 - HPRD 12105213
GORASP2 DKFZP434D156 |FLJ13139 |Golph6 |grasp55 |grs2 |P59 golgi reassembly stacking protein 2, 55kDa Two-hybrid Biogrid 16189514
ITGB1 CD29 |fnrb |GPIIA |MDF2 |MSK12 |vla-beta |vlab integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) - HPRD,BioGRID 11919189
NME1 AWD |GAAD |NB |NBS |NDPK-A |ndpka |NM23 |NM23-H1 non-metastatic cells 1, protein (NM23A) expressed in - HPRD,BioGRID 11835509
NME3 dr-nm23 |KIAA0516 |NDPK-C |NDPKC |NM23-H3 |C371H6.2 non-metastatic cells 3, protein expressed in - HPRD,BioGRID 11042679
NME4 NDPK-D | NM23H4 | nm23-H4 非转移细胞4，蛋白质在 Two-hybrid Biogrid 16189514
polr1c RPA39 | RPA40 | RPA5 | RPAC1 polymerase (RNA) I polypeptide C, 30kDa Two-hybrid Biogrid 16189514
PRUNE DRES-17 | HTCD37 prune homolog (Drosophila) - HPRD 10602478 | 11687967
PRUNE DRES-17 | HTCD37 prune homolog (Drosophila) - HPRD,BioGRID 10602478
罗拉 DKFZP686M2414 |MGC119326 |MGC119329 |NR1F1 |ROR1 |ROR2 |ROR3 |rzr-alpha |rzra RAR相关的孤儿受体A - HPRD,BioGRID 8858107
罗布 NR1F2 | ROR-BETA | RZR-BETA | RZRB | bA133M9.1 与RAR相关的孤儿受体B - HPRD,BioGRID 8858107
rrad rad |rad1 |REM3 Ras-related associated with diabetes - HPRD 11280768
rrad rad |rad1 |REM3 Ras-related associated with diabetes - HPRD,BioGRID 10611312 | 11280768
放 2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETA 放nuclear oncogene - HPRD,BioGRID 12628186
terf1 FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1 端粒重复结合因子（NIMA相互作用）1 重构的复合物
Two-hybrid		 Biogrid 9480811
提亚姆1 FLJ36302 T细胞淋巴瘤侵袭和转移1 - HPRD,BioGRID 11274357
wdyhv1 C8orf32 | FLJ10204 WDYHV motif containing 1 Two-hybrid Biogrid 16189514


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG嘧啶代谢 98 53 All SZGR 2.0 genes in this pathway
BIOCARTA NDKDYNAMIN PATHWAY 21 15 All SZGR 2.0 genes in this pathway
Biocarta设定途径 11 6 All SZGR 2.0 genes in this pathway
PID MYC活动途径 79 62 All SZGR 2.0 genes in this pathway
PID ARF6贩运途径 49 34 All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 30 22 All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 15 14 All SZGR 2.0 genes in this pathway
pid ajdiss 2Pathway 48 38 All SZGR 2.0 genes in this pathway
PID Ecadherin新生AJ途径 39 33 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF NUCLEOTIDES 72 45 All SZGR 2.0 genes in this pathway
核苷酸DI和三磷酸的反应组合成和互转换 19 10 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央 285 181 All SZGR 2.0 genes in this pathway
sotiriou乳腺癌1级vs 3 151 84 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
加里CD5 DN的目标 431 263 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
vecchi胃癌早期 430 232 All SZGR 2.0 genes in this pathway
AKL HTLV1感染 27 16 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标 204 140 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
Jaatinen造血干细胞向上 316 190 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺48小时DN 64 39 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺96小时DN 75 50 All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment 536 340 All SZGR 2.0 genes in this pathway
lastowska神经母细胞瘤复制编号 181 108 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
Schlosser MYC靶标和血清反应 47 32 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
Dairkee Tert目标 380 213 All SZGR 2.0 genes in this pathway
Kim Myc放大靶向 201 127 All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 92 64 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
Rahman TP53靶向磷酸化 21 18 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 DN 59 35 All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标 230 156 All SZGR 2.0 genes in this pathway
Benporath Myc Max目标 775 494 All SZGR 2.0 genes in this pathway
Stark前额叶皮层22Q11删除DN 517 309 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
戈德拉斯体内平衡增殖 171 102 All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 53 35 All SZGR 2.0 genes in this pathway
YAGI AML RELAPSE PROGNOSIS 35 24 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
西葫芦转移 43 24 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束 182 116 All SZGR 2.0 genes in this pathway
Schuhmacher MYC的目标 80 57 All SZGR 2.0 genes in this pathway
SANA对IFNG DN的回应 85 56 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP 45 30 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
Sasaki成人T细胞白血病 176 122 All SZGR 2.0 genes in this pathway
彭雷帕霉素反应dn 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
LEI MYB目标 318 215 All SZGR 2.0 genes in this pathway
棕色髓样细胞发育DN 129 86 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
Yagi AML生存 129 87 All SZGR 2.0 genes in this pathway
Schlingemann皮肤致癌作用TPA 42 24 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
PAL PRMT5靶向 203 135 All SZGR 2.0 genes in this pathway
村上紫外线响应6小时 37 31 All SZGR 2.0 genes in this pathway
Rhodes未分化的癌症 69 44 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C1 19 15 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
MULLIGAN NTF3 SIGNALING VIA INSR AND IGF1R UP 23 16 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
江口大脑皮层DN 54 43 All SZGR 2.0 genes in this pathway
约瑟夫对丁酸钠的反应 31 21 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应 1011 592 All SZGR 2.0 genes in this pathway
Hillion HMGA1目标 90 71 All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标 92 68 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
Sansom APC MYC目标 217 138 All SZGR 2.0 genes in this pathway
Sansom APC目标需要MYC 210 123 All SZGR 2.0 genes in this pathway
怀特福德小儿癌标记 116 63 All SZGR 2.0 genes in this pathway
级结肠癌 871 505 All SZGR 2.0 genes in this pathway
Mueller Plurinet 299 189 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 51 32 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
Chang Core血清反应 212 128 All SZGR 2.0 genes in this pathway
Aguirre胰腺癌复制号 298 174 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
Han Satb1靶向DN 442 275 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
Kobayashi EGFR信令24小时DN 251 151 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
winnepenninckx黑色素瘤转移 162 86 All SZGR 2.0 genes in this pathway
党MYC目标了 143 100 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
YAO对孕酮簇2的时间反应2 86 50 All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应14 143 86 All SZGR 2.0 genes in this pathway
村上紫外线响应1小时 17 10 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN 882 538 All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标 824 528 All SZGR 2.0 genes in this pathway