Gene Page:NQO2

Summary?
GeneID 4835
Symbol NQO2
Synonyms DHQV|DIA6|NMOR2|QR2
Description NAD(P)H dehydrogenase, quinone 2
Reference MIM:160998|HGNC:HGNC:7856|Ensembl:ENSG00000124588|HPRD:01190|Vega:OTTHUMG00000014130
Gene type protein-coding
Map location 6p25.2
Pascal p-value 0.144
Sherlock p-value 0.5
Fetal beta -1.483
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellar Hemisphere
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0159
Literature High-throughput literature-search Co-occurance与精神分裂症nia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26943189 6 3002278 NQO2 1.24E-5 -0.546 0.014 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9405188 6 2997544 NQO2 ENSG00000124588.15 5.08434E-9 0 3379 gtex_brain_putamen_basal
rs6596927 6 2998319 NQO2 ENSG00000124588.15 1.45769E-6 0 4154 gtex_brain_putamen_basal
rs2071002 6 3000303 NQO2 ENSG00000124588.15 2.07243E-7 0 6138 gtex_brain_putamen_basal
rs9378754 6 3000832 NQO2 ENSG00000124588.15 1.67035E-6 0 6667 gtex_brain_putamen_basal
rs9378755 6 3000978 NQO2 ENSG00000124588.15 1.56508E-9 0 6813 gtex_brain_putamen_basal
rs9392449 6 3001431 NQO2 ENSG00000124588.15 1.4107E-7 0 7266 gtex_brain_putamen_basal
rs138616686 6 3003970 NQO2 ENSG00000124588.15 8.53875E-8 0 9805 gtex_brain_putamen_basal
rs4149360 6 3006807 NQO2 ENSG00000124588.15 1.04308E-7 0 12642 gtex_brain_putamen_basal
rs4149363 6 3007478 NQO2 ENSG00000124588.15 2.47705E-7 0 13313 gtex_brain_putamen_basal
rs62392497 6 3017861 NQO2 ENSG00000124588.15 1.60818E-6 0 23696 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0001512 dihydronicotinamide riboside quinone reductase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0008753 NADPH dehydrogenase (quinone) activity TAS 1691923
GO:0009055 electron carrier activity IEA -
GO:0009055 electron carrier activity TAS 1691923
GO:0016491 oxidoreductase activity IEA -
GO:0046872 metal ion binding IEA -
GO:0050662 辅酶绑定 IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 52 34 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART VENTRICLE DN 41 28 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 69 46 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 76 51 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 89 57 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP 61 41 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway