Gene Page:NMT1

Summary?
GeneID 4836
Symbol NMT1
Synonyms NMT
Description N-myristoyltransferase 1
Reference MIM:160993|HGNC:HGNC:7857|Ensembl:ENSG00000136448|HPRD:01187|Vega:OTTHUMG00000180003
Gene type protein-coding
Map location 17q21.31
Pascal p-value 0.01
Sherlock p-value 0.985
Fetal beta -1.656
DMG 1 (# studies)
eGene Putamen basal ganglia
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0351

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16080654 17 43176852 NMT1 5.725E-4 0.403 0.049 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs149804735 17 43349729 NMT1 ENSG00000136448.7 3.202E-6 0.04 211078 gtex_brain_putamen_basal
rs17685379 17 43352049 NMT1 ENSG00000136448.7 3.232E-6 0.04 213398 gtex_brain_putamen_basal
rs3785803 17 43361213 NMT1 ENSG00000136448.7 3.472E-6 0.04 222562 gtex_brain_putamen_basal
rs11079503 17 43365089 NMT1 ENSG00000136448.7 3.258E-6 0.04 226438 gtex_brain_putamen_basal
rs11574815 17 43365392 NMT1 ENSG00000136448.7 3.314E-6 0.04 226741 gtex_brain_putamen_basal
rs35518221 17 43365441 NMT1 ENSG00000136448.7 3.317E-6 0.04 226790 gtex_brain_putamen_basal
rs111882557 17 43377320 NMT1 ENSG00000136448.7 3.57E-6 0.04 238669 gtex_brain_putamen_basal
rs149586082 17 43377551 NMT1 ENSG00000136448.7 3.572E-6 0.04 238900 gtex_brain_putamen_basal
rs112969331 17 43378398 NMT1 ENSG00000136448.7 3.58E-6 0.04 239747 gtex_brain_putamen_basal
rs79442196 17 43379488 NMT1 ENSG00000136448.7 3.592E-6 0.04 240837 gtex_brain_putamen_basal
rs111244088 17 43379765 NMT1 ENSG00000136448.7 3.594E-6 0.04 241114 gtex_brain_putamen_basal
rs75911690 17 43380115 NMT1 ENSG00000136448.7 3.599E-6 0.04 241464 gtex_brain_putamen_basal
rs79789477 17 43380341 NMT1 ENSG00000136448.7 3.599E-6 0.04 241690 gtex_brain_putamen_basal
rs1476533 17 43383595 NMT1 ENSG00000136448.7 3.444E-6 0.04 244944 gtex_brain_putamen_basal
rs75184106 17 43385263 NMT1 ENSG00000136448.7 3.371E-6 0.04 246612 gtex_brain_putamen_basal
rs79039330 17 43385620 NMT1 ENSG00000136448.7 3.357E-6 0.04 246969 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TSNAXIP1 0.85 0.64
WDR66 0.85 0.69
DLEC1 0.83 0.56
CCDC39 0.83 0.64
AC079354.2 0.83 0.62
C7orf63 0.83 0.65
DNAH2 0.82 0.59
LRP2BP 0.82 0.53
RPGR 0.82 0.55
ZBBX 0.82 0.61
十大负面中的基因
Gene Pearson's Correlation Spearman's Correlation
TBR1 -0.34 -0.25
SOX5 -0.33 -0.16
AFF3 -0.32 -0.15
ID2 -0.32 -0.29
NEUROD2 -0.31 -0.21
PRDM8 -0.31 -0.21
BACH2 -0.31 -0.12
DAB1 -0.31 -0.14
TSHZ3 -0.31 -0.17
KCTD12 -0.31 -0.19

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001701 in utero embryonic development IEA -
GO:0006499 N-terminal protein myristoylation NAS -
GO:0009249 protein lipoylation TAS 9506952
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 11099414
GO:0005575 cellular_component ND -
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 125 69 All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 104 61 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 30 21 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 50 36 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 73 45 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C4 20 14 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 46 38 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 63 44 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE UP 12 9 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 172 107 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 145 82 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

米尔NA family Target position 米尔NA ID 米尔NA seq
UTR start UTR end Match method
米尔-124/506 1060 1066 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
米尔-138 2898 2904 1A hsa-miR-138brain AGCUGGUGUUGUGAAUC
米尔-143 3338 3344 1A hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
米尔-204/211 251 257 1A hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
米尔-214 263 269 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
米尔-330 570 576 1A hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
米尔-362 379 385 m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
米尔-369-3p 331 337 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
米尔-374 331 337 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
米尔-410 333 339 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
米尔-493-5p 374 381 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
米尔-7 742 748 1A hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
米尔-9 1821 1828 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA