Gene Page:NOS3

概括?
基因 4846
象征 NOS3
Synonyms ecnos | eNos
Description nitric oxide synthase 3
Reference MIM:163729|HGNC:HGNC:7876|Ensembl:ENSG00000164867|HPRD:01224|Vega:OTTHUMG00000158343
Gene type protein-coding
Map location 7q36
Pascal p-value 0.26
TADA p-value 0.023
eGene Myers' cis & trans
元
Support COMPOSITESET

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM：Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与Sc Co-occurancehizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
NOS3 chr7 150707820 T G NM_000603 p.941S>A missense 精神分裂症 DNM：Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7370564 0 NOS3 4846 0.15 trans
rs443832 chr16 83779643 NOS3 4846 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003785 actin monomer binding 新闻学会 17502619
GO:0005506 铁离子结合 IEA -
GO:0005509 钙离子结合 IEA -
GO:0005516 calmodulin binding IEA -
GO:0004517 nitric-oxide synthase activity IEA -
GO:0020037 heme binding IEA -
GO:0008270 zinc ion binding IEA -
GO:0010181 FMN binding IEA -
去：0009055 电子载体活动 IEA -
GO:0016491 oxidoreductase activity IEA -
GO:0034617 tetrahydrobiopterin binding IDA 7488039
GO:0034618 arginine binding IDA 7488039
GO:0046870 cadmium ion binding NAS 7488039
GO:0050660 FAD binding IEA -
GO:0050661 NADP binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0001542 ovulation from ovarian follicle IEA -
GO:0002028 钠离子运输的调节 IEA -
GO:0003100 regulation of systemic arterial blood pressure by endothelin IMP 8999856
GO:0001974 blood vessel remodeling ISS -
GO:0006527 arginine catabolic process IDA 1378832|7488039
GO:0008217 regulation of blood pressure NAS 7504210
GO:0010544 negative regulation of platelet activation NAS 7504210
GO:0008285 negative regulation of cell proliferation ISS -
GO:0009408 response to heat NAS 18048451
GO:0007612 learning IEA -
去：0006809 nitric oxide biosynthetic process IEA -
GO:0007005 线粒体组织 ISS -
GO:0006916 anti-apoptosis ISS -
GO:0014740 negative regulation of muscle hyperplasia ISS -
GO:0014806 smooth muscle hyperplasia ISS -
GO：0051346 negative regulation of hydrolase activity IEA -
GO:0031284 positive regulation of guanylate cyclase activity IMP 17502619
GO:0031284 positive regulation of guanylate cyclase activity ISS -
GO:0034405 response to fluid shear stress IEP 10376603
GO：0030324 lung development IEA -
GO：0031663 lipopolysaccharide-mediated signaling pathway IEA -
GO:0043267 negative regulation of potassium ion transport IEA -
GO:0045766 positive regulation of angiogenesis ISS -
GO：0045909 positive regulation of vasodilation NAS 18048451
GO:0050880 regulation of blood vessel size ISS -
GO:0050880 regulation of blood vessel size NAS 7504210
GO:0043542 endothelial cell migration IMP 8999856
GO:0055114 oxidation reduction IEA -
GO:0051926 negative regulation of calcium ion transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane 经验 9188442|9580552|10781589
|11149895|16722822
|16807357
GO:0005794 Golgi apparatus IEA -
GO:0005829 cytosol 经验 7512951|10559837
GO:0005856 cytoskeleton IEA -
GO:0005634 nucleus ISS -
GO:0005737 细胞质 IEA -
GO:0005901 caveola IDA 17502619|17848177
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ARGININE AND PROLINE METABOLISM 54 39 该途径中的所有SZGR 2.0基因
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG VEGF SIGNALING PATHWAY 76 53 该途径中的所有SZGR 2.0基因
BIOCARTA第一途径 33 24 该途径中的所有SZGR 2.0基因
BIOCARTA GCR PATHWAY 22 17 该途径中的所有SZGR 2.0基因
BIOCARTA HIF PATHWAY 15 12 该途径中的所有SZGR 2.0基因
BIOCARTA VEGF PATHWAY 29 18 该途径中的所有SZGR 2.0基因
PID ER NONGENOMIC PATHWAY 41 35 该途径中的所有SZGR 2.0基因
PID FRA PATHWAY 37 28 该途径中的所有SZGR 2.0基因
PID ANGIOPOIETIN RECEPTOR PATHWAY 50 41 该途径中的所有SZGR 2.0基因
PID TXA2PATHWAY 57 43 该途径中的所有SZGR 2.0基因
PID SHP2 PATHWAY 58 46 该途径中的所有SZGR 2.0基因
PID VEGFR1 PATHWAY 26 23 该途径中的所有SZGR 2.0基因
PID VEGFR1 2 PATHWAY 69 57 该途径中的所有SZGR 2.0基因
PID THROMBIN PAR1 PATHWAY 43 32 该途径中的所有SZGR 2.0基因
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 13 9 该途径中的所有SZGR 2.0基因
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 33 15 该途径中的所有SZGR 2.0基因
REACTOME ENOS ACTIVATION AND REGULATION 20 14 该途径中的所有SZGR 2.0基因
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 25 19 该途径中的所有SZGR 2.0基因
REACTOME PLATELET HOMEOSTASIS 78 49 该途径中的所有SZGR 2.0基因
REACTOME HEMOSTASIS 466 331 该途径中的所有SZGR 2.0基因
GARY CD5 TARGETS UP 473 314 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 该途径中的所有SZGR 2.0基因
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 该途径中的所有SZGR 2.0基因
Hatada甲基化在肺癌中 390 236 该途径中的所有SZGR 2.0基因
SANA TNF SIGNALING DN 90 57 该途径中的所有SZGR 2.0基因
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 该途径中的所有SZGR 2.0基因
李小脑老化 84 58 该途径中的所有SZGR 2.0基因
Hillion HMGA1B目标 92 68 该途径中的所有SZGR 2.0基因
MATZUK OVULATION 14 10 该途径中的所有SZGR 2.0基因
Matzuk减数分裂和DNA修复 39 26 该途径中的所有SZGR 2.0基因
WINTER HYPOXIA METAGENE 242 168 该途径中的所有SZGR 2.0基因
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196 124 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 该途径中的所有SZGR 2.0基因
MIKKELSEN ES LCP WITH H3K4ME3 142 80 该途径中的所有SZGR 2.0基因
figueroa aml甲基化簇3 dn 42 24 该途径中的所有SZGR 2.0基因
FOSTER KDM1A TARGETS DN 211 119 该途径中的所有SZGR 2.0基因