Gene Page:NPM1
Summary?
| GeneID | 4869 |
| Symbol | NPM1 |
| Synonyms | B23|NPM |
| Description | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
| Reference | MIM:164040|HGNC:HGNC:7910|Ensembl:ENSG00000181163|HPRD:01246|Vega:OTTHUMG00000130465 |
| Gene type | 蛋白质n-coding |
| Map location | 5q35.1 |
| Pascal p-value | 0.045 |
| Sherlock p-value | 0.318 |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.0276 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0597 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ITPKA | 0.90 | 0.92 |
| GRASP | 0.85 | 0.91 |
| CAMK2N1 | 0.84 | 0.77 |
| MYPOP | 0.83 | 0.75 |
| NECAB3 | 0.80 | 0.65 |
| ASPHD1 | 0.80 | 0.88 |
| TMEM38A | 0.80 | 0.88 |
| CACNA1F | 0.80 | 0.85 |
| DDN | 0.80 | 0.93 |
| FAM131A | 0.80 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FADS2 | -0.55 | -0.64 |
| KIAA1949 | -0.53 | -0.61 |
| TUBB2B | -0.53 | -0.68 |
| GPR125 | -0.52 | -0.57 |
| TIGD1 | -0.51 | -0.61 |
| SH3BP2 | -0.51 | -0.66 |
| IDH1 | -0.50 | -0.63 |
| SEMA4B | -0.50 | -0.60 |
| ZNF193 | -0.50 | -0.60 |
| AF186192.1 | -0.50 | -0.67 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0003713 | transcription coactivator activity | 艾达 | 15087454 | |
| GO:0003723 | RNA binding | TAS | 9121481 | |
| GO:0051082 | unfolded protein binding | 艾达 | 10211837 | |
| GO:0051082 | unfolded protein binding | ISS | - | |
| GO:0051059 | NF-kappaB binding | 艾达 | 15087454 | |
| GO:0051059 | NF-kappaB binding | ISS | - | |
| GO:0030957 | Tat protein binding | 艾达 | 9094689 | |
| GO:0042803 | 蛋白质n homodimerization activity | 艾达 | 9121481 | |
| GO:0046982 | 蛋白质n heterodimerization activity | IMP | 12080348 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006950 | response to stress | IMP | 12080348 | |
| GO:0007165 | signal transduction | TAS | 16130169 | |
| GO:0007098 | centrosome cycle | IMP | 11051553 | |
| GO:0007098 | centrosome cycle | ISS | - | |
| GO:0008285 | negative regulation of cell proliferation | IMP | 12080348 | |
| GO:0008285 | negative regulation of cell proliferation | ISS | - | |
| GO:0007569 | cell aging | IMP | 12080348 | |
| GO:0007569 | cell aging | ISS | - | |
| GO:0006916 | anti-apoptosis | TAS | 16130169 | |
| GO:0006913 | nucleocytoplasmic transport | TAS | 12080348 | |
| GO:0006886 | intracellular protein transport | TAS | 12080348 | |
| GO:0042255 | ribosome assembly | TAS | 12080348 | |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IMP | 15087454 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005813 | centrosome | 艾达 | 11051553 | |
| GO:0005813 | centrosome | ISS | - | |
| GO:0005634 | nucleus | 艾达 | 12080348 | |
| GO:0005634 | nucleus | ISS | - | |
| GO:0005634 | nucleus | TAS | 16130169 | |
| GO:0005730 | nucleolus | 艾达 | 12080348|17475909 | |
| GO:0005737 | cytoplasm | 艾达 | 9121481 | |
| GO:0005737 | cytoplasm | ISS | - | |
| GO:0005737 | cytoplasm | TAS | 16130169 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ALK | CD246 | Ki-1 | TFG/ALK | anaplastic lymphoma receptor tyrosine kinase | - | HPRD | 11888936 |
| ARF1 | - | ADP-ribosylation factor 1 | - | HPRD | 14636574|15684379 |
| BARD1 | - | 乳腺癌易感基因1associated RING domain 1 | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex |
BioGRID | 15184379 |
| 乳腺癌易感基因1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex |
BioGRID | 15184379 |
| EIF2AK2 | EIF2AK1 | MGC126524 | PKR | PRKR | eukaryotic translation initiation factor 2-alpha kinase 2 | - | HPRD | 12882984 |
| GADD45A | DDIT1 | GADD45 | growth arrest and DNA-damage-inducible, alpha | - | HPRD | 15644315 |
| HAND2 | DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHand | heart and neural crest derivatives expressed 2 | - | HPRD,BioGRID | 11812799 |
| HIST3H3 | H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888 | histone cluster 3, H3 | - | HPRD,BioGRID | 11602260 |
| LYAR | FLJ20425 | ZLYAR | Ly1 antibody reactive homolog (mouse) | Affinity Capture-MS | BioGRID | 17353931 |
| MAP3K14 | FTDCR1B | HS | HSNIK | NIK | mitogen-activated protein kinase kinase kinase 14 | - | HPRD | 14743216 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Myc interacts with NPM1 (B23) | BIND | 15944709 |
| NCL | C23 | FLJ45706 | nucleolin | - | HPRD,BioGRID | 8620867|10503877 |
| NOP2 | MGC117384 | MGC149287 | MGC149288 | NOL1 | NOP120 | NSUN1 | p120 | NOP2 nucleolar protein homolog (yeast) | - | HPRD | 8089149 |
| PLK1 | PLK | STPK13 | polo-like kinase 1 (Drosophila) | - | HPRD | 15190079 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | - | HPRD | 14743216 |
| SFRS12 | DKFZp564B176 | MGC133045 | SRrp508 | SRrp86 | splicing factor, arginine/serine-rich 12 | - | HPRD | 14559993 |
| SWAP70 | FLJ39540 | HSPC321 | KIAA0640 | SWAP-70 | SWAP-70 protein | - | HPRD,BioGRID | 9642267 |
| TCERG1 | CA150 | MGC133200 | TAF2S | transcription elongation regulator 1 | - | HPRD,BioGRID | 15456888 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | - | HPRD | 12080348 |
| USF2 | FIP | bHLHb12 | upstream transcription factor 2, c-fos interacting | Affinity Capture-MS | BioGRID | 17353931 |
| XPO1 | CRM1 | DKFZp686B1823 | exportin 1 (CRM1 homolog, yeast) | An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1). | BIND | 16041368 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID AURORA B PATHWAY | 39 | 24 | All SZGR 2.0 genes in this pathway |
| PID MYC ACTIV PATHWAY | 79 | 62 | All SZGR 2.0 genes in this pathway |
| PID HIF1 TFPATHWAY | 66 | 52 | All SZGR 2.0 genes in this pathway |
| PID BARD1 PATHWAY | 29 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME CHROMOSOME MAINTENANCE | 122 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | 146 | 86 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP | 204 | 140 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 DN | 229 | 142 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| CAIRO PML TARGETS BOUND BY MYC UP | 23 | 17 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| SEIDEN ONCOGENESIS BY MET | 88 | 53 | All SZGR 2.0 genes in this pathway |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 27 | 15 | 8 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| AMUNDSON RESPONSE TO ARSENITE | 217 | 143 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| GARCIA TARGETS OF FLI1 AND DAX1 DN | 176 | 104 | All SZGR 2.0 genes in this pathway |
| DEN INTERACT WITH LCA5 | 26 | 21 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
| PARK HSC VS MULTIPOTENT PROGENITORS DN | 18 | 12 | All SZGR 2.0 genes in this pathway |
| MENSSEN MYC TARGETS | 53 | 35 | All SZGR 2.0 genes in this pathway |
| BHATTACHARYA EMBRYONIC STEM CELL | 89 | 60 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT DN | 129 | 86 | All SZGR 2.0 genes in this pathway |
| HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR | 55 | 38 | All SZGR 2.0 genes in this pathway |
| JIANG VHL TARGETS | 138 | 91 | All SZGR 2.0 genes in this pathway |
| ZHU CMV ALL UP | 120 | 89 | All SZGR 2.0 genes in this pathway |
| ZHU CMV 24 HR UP | 93 | 65 | All SZGR 2.0 genes in this pathway |
| BILD MYC ONCOGENIC SIGNATURE | 206 | 117 | All SZGR 2.0 genes in this pathway |
| ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST | 132 | 93 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS DN | 120 | 81 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | All SZGR 2.0 genes in this pathway |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | 52 | 25 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL DN | 175 | 103 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| IRITANI MAD1 TARGETS DN | 47 | 30 | All SZGR 2.0 genes in this pathway |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| 党MYC目标了 | 143 | 100 | All SZGR 2.0 genes in this pathway |
| 党受MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| WU APOPTOSIS BY CDKN1A VIA TP53 | 55 | 31 | All SZGR 2.0 genes in this pathway |
| BAE BRCA1 TARGETS DN | 32 | 27 | All SZGR 2.0 genes in this pathway |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN | 103 | 67 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |